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Vitamin D new study

vitamin d

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#1 geo12the

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Posted 31 July 2014 - 04:22 PM


FYI:   Cardiovascular disease and vitamin D supplementation: trial analysis, systematic review, and meta-analysis1,2,3,4
  1. John A Ford
  2. Graeme S MacLennan
  3. Alison Avenell
  4. Mark Bolland,
  5. Andrew Grey
  6. Miles Witham
  7. for the RECORD Trial Group

+Author Affiliations

  1. 1From the Health Services Research Unit, University of Aberdeen, Aberdeen, United Kingdom (JAF, GSM, and AA); the Department of Medicine, University of Auckland, Auckland, New Zealand (MB and AG); and the Section of Aging and Health, University of Dundee, Dundee, United Kingdom (MW).

+Author Notes

  • 2 The trial was conducted, analyzed, and reported independently of all funders.

  • 3 The Medical Research Council funded the central organization of RECORD, and Shire Pharmaceuticals funded the drugs, which were cofunded and manufactured by Nycomed. The Health Services Research Unit, University of Aberdeen, is funded by the Chief Scientist Office of the Scottish Government Health and Social Care Directorates.

  • 4 Address reprint requests and correspondence to JA Ford, Norwich Medical School, Faculty of Medicine and Health Sciences, University of East Anglia, Chancellors Drive, Norwich NR4 7TJ, United Kingdom. E-mail: john.ford@uea.ac.uk.

Abstract

Background: Low 25-hydroxyvitamin D status has been associated with increased cardiovascular events in epidemiologic studies.

Objective: We assessed whether vitamin D supplementation reduces cardiac failure, myocardial infarction (MI), and stroke through an analysis of the Randomised Evaluation of Calcium Or vitamin D (RECORD) randomized controlled trial (RCT), a systematic review, and a meta-analysis.

Design: Two analyses were undertaken. The first analysis was a trial analysis. The RECORD was a factorial RCT that compared vitamin D3 (800 IU/d), calcium (1000 mg/d), vitamin D plus calcium, and a placebo. Cardiovascular events were collected throughout the trial and 3-y posttrial follow-up. Data were analyzed by using Cox regression. The second analysis was a systematic review. MEDLINE, EMBASE, CENTRAL, conference abstracts, and ongoing trials were searched for RCTs that evaluated vitamin D from 1980 to 2013. RCTs with ≥1 y of follow-up and participants mean or median age ≥60 y were included. Meta-analyses were based on a Bayesian fixed-effects model by using a complementary log-log link function to account for varying lengths of follow-up.

Results: In the trial analysis, we showed that, for the 5292 participants in the RECORD trial, HRs (95% CIs) for vitamin D compared with no vitamin D for cardiac failure, MI, and stroke were 0.75 (0.58, 0.97), 0.97 (0.75,1.26), and 1.06 (0.8, 1.32), respectively. Twenty-one studies met the inclusion criteria for the systematic review (n = 13,033). Estimated HRs [credible intervals (CrIs)] for vitamin D compared with the placebo or control for on-study events for cardiac failure, MI, and stroke were 0.82 (0.58, 1.15), 0.96 ( 0.83, 1.10), and 1.07 (0.91, 1.29), respectively.

Conclusion: Vitamin D supplementation might protect against cardiac failure in older people but does not appear to protect against MI or stroke.

http://www.nutraingr...IidZWSxUz9W+A==


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