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can I use cdp choline instead of uridine in uridine/dha/choline combo

cdp choline uridine

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#1 somethingstrange

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Posted 01 August 2014 - 01:14 PM


From what I've read it seems that uridine is just a substrate in reaction to build cdp choline or am I wrong ?



#2 William Sterog

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Posted 02 December 2014 - 12:53 PM

I was wondering the same thing.

 

http://wurtmanlab.mi...tic/pdf/972.pdf

 

 

ABSTRACT. Twelve mildly hypertensive but otherwise normal fasting subjects received each of four

treatments in random order: CDP-choline (citicoline; 500, 2000, and 4000 mg) or a placebo orally at 8:00 a.m.
on four different treatment days. Eleven plasma samples from each subject, obtained just prior to treatment (8:00
a.m.) and 1–12 hr thereafter, were assayed for choline, cytidine, and uridine. Fasting terminated at noon with
consumption of a light lunch that contained about 100 mg choline. Plasma choline exhibited dose-related
increases in peak values and areas under the curves (AUCs), remaining significantly elevated, after each of the
three doses, for 5, 8, and 10 hr, respectively. Plasma uridine was elevated significantly for 5–6 hr after all three
doses, increasing by as much as 70–90% after the 500 mg dose, and by 100–120% after the 2000 mg dose. No
further increase was noted when the dose was raised from 2000 to 4000 mg. Plasma cytidine was not reliably
detectable, since it was less than twice blank, or less than 100 nM, at all of the doses. Uridine is known to enter
the brain and to be converted to UTP; moreover, we found that uridine was converted directly to CTP in
neuron-derived PC-12 cells. Hence, it seems likely that the circulating substrates through which oral citicoline
increases membrane phosphatide synthesis in the brains of humans involve uridine and choline, and not cytidine
and choline as in rats.

 


Edited by William Sterog, 02 December 2014 - 12:54 PM.


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