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Internal bleeding (liver damage/ alcoholism)

liver health bleeding internal bleeding alcohol surgery transplant

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#1 nubiensunset

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Posted 02 August 2014 - 02:47 PM


Hey,

 

My friends dad is in the hospital, they found out he has internal bleeding. It sounds like it is the result of his liver from previous years of alcohol abuse. My friend is obviously scared and concerned for his dad but they will find out more today about how bad the damage is (going to go in with a camera I believe).

I'm just curious if there are any cutting edge or new treatments out there for internal bleeding and liver damage that the doctors might not offer him?

 

My friend also said he is not capable of having a liver transplant because of his previous years of alcohol abuse.

 

 

 



#2 joelcairo

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Posted 02 August 2014 - 07:32 PM

I don't know much about cirrhosis, but I have looked into the biological effects of serum albumin, which is decreased in cirrhosis and in fact in almost all human disease. Some sources almost dismiss it as being mainly involved in the osmotic pressure of the blood, but it does so much more than that.

 

It looks like two interrelated strategies to improve the outcome would be to reduce PGE2 and increase albumin.

 

Replacing albumin is an old idea, and can be easily done. From what I can see, it is not usually used because after infusion, albumin levels return to the baseline level in a couple of days. My personal response to that is "so what?" Let two days from now take care of itself. Maybe keep infusing until the liver has had sufficient time to heal somewhat.

 

Dietary albumin will have little if any effect. Certain anti-inflammatories would be helpful in reducing PGE2 and protecting albumin levels, but you'd have to find ones that didn't out any strain on the liver.

 

Needless to say, this would only be a viable strategy if the drinking had been stopped permanently.

 

Here are some links that may be helpful...

 

-----------------------------

 

Mechanism, possible treatment, for immune suppression in liver disease uncovered
http://www.scienceda...40413135951.htm
- hyper susceptibility to infection in cirrhosis patients is due to the over production of the lipid hormone prostaglandin E2 (PGE2).
- This hormone prevents white blood cells from ingesting bacteria and killing them.
- Researchers also found that a decreased concentration globular blood protein albumin, which catalyses the inactivation of PGE2 in liver
  disease patients was contributing to low immunity.

Is the use of albumin of value in the treatment of ascites in cirrhosis? The case in favour.
http://www.ncbi.nlm....pubmed/14563190

The role of albumin in critical illness
http://bja.oxfordjou...t/85/4/599.full
 



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#3 xEva

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Posted 02 August 2014 - 09:23 PM

nubiensunset, afak variceal hemorrhage in cirrhotics is due to liver being so scarred that it cannot adequately filter blood, which increases the pressure in vessels and forces the blood to bypass the liver. This leads to formation of internal varicose veins. In addition, there are some deficiencies due to impaired liver function that weakens vessels walls. All this increases chances of a vein rupturing at some point.

There are procedures aimed at stopping  internal bleeding and therapies trying to prevent it, but ultimately, without fixing the underlying liver problem, they are just temporary measures.


Edited by xEva, 02 August 2014 - 09:30 PM.






Also tagged with one or more of these keywords: liver, health, bleeding, internal bleeding, alcohol, surgery, transplant

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