5 replies to this topic

[ImmortalSpace]

So I've read tons of ncbi articles on L-Carnosine and they all seem positive.

I bought Now foods 500 mg, I tried half that amount. I seemed fine..

Yet im still afraid to take them. My question is simply, are they safe?

Post your experiences below. 

[blood]

Yes, safe.

 

Safe, that is, if you purchased from a reputable vendor (Jarrow, Swanson, Drs Best, LEF, NOW, etc - i.e., anything you can pick up on on iherb)

 

If you purchased from alibaba, ebay, or any of the myriad of dodgy pharmaceutical vendors (TeamTLR, New Star Nootropic, etc) promoting their junk on this forum, then you can't be sure, because none of these companies do finished product testing.

Edited by blood, 24 August 2014 - 01:39 AM.

[PeaceAndProsperity]

Sorry to resurrect an ancient thread but carnosine as a telomerase activator seems interesting.

Has anyone tried megadosing it longterm? Done any tests? I reckon it's very ineffective at lengthening telomeres

[miker2016]

I have been taking Carnosine more than any other supplement. I started when I read it could replenish your telomeres. I have had no ill effects. Whether it works or not hard to say. One way is to have a blood test done to see what your telomere length is but I can't afford it and I am not sure it works.

[PeaceAndProsperity]

I have been taking Carnosine more than any other supplement. I started when I read it could replenish your telomeres. I have had no ill effects. Whether it works or not hard to say. One way is to have a blood test done to see what your telomere length is but I can't afford it and I am not sure it works.

Did your skin get younger looking? What's your age?

[Nate-2004]

I've been taking it for a year or more now. I would say my skin looks younger than it did a year ago but also I can't say that it's necessarily the carnosine. I do not think it lengthens telomeres and I've not heard this anywhere. We need a whole section on glycation though because it's a major factor in aging and is not getting near the attention it needs.

 

For one thing during that time I learned more about carnosine and other so called glycation blockers. Carnosine's mechanism of action involves cleaving transition metals from your system. It's also a mild antioxidant from what I understand.

 

ROS and transition metals are just one pathway for glycation to take. The problem with trying to prevent glycation though is that it's just going to take another pathway when forging crosslinks with collagen.  It's why SENS gave up on trying to prevent glycation and decided to find ways to break crosslinks instead.

 

I bought a lot of it though and have continued taking it. I'm not sure it's worthwhile and may not resupply when I'm out, in light of that information. You may be better off trying to change to a diet that is less prone to glycation or one that contains fewer exogenous AGEs by not cooking food or limit cooking to boiling temps at the highest. Eat your steaks as rare as you can in other words, or just eat raw fish like Salmon which is probably safer if you like sushi.

 

There are other threads on glycation that may be of interest.

 

I would spend all the money you would otherwise spend on Carnosine by donating to SENS and telling them you want that reserved for AGE breaking research, that or donate it directly to Spiegel labs who from what I understand, has successfully managed to synthesize glucosepane.