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Health Crash

nootropics racetams trt hormones testosterone noopept

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#1 perplex

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Posted 16 August 2014 - 03:35 PM


Hi Everyone!

8 months ago -  It all started with sexual dysfunction (including loss of sensitivity), extreme fatigue, tingling sensation in my hands and feet, blood pressure problems, constipation, extreme brain-fog. These last months have not been. I’m having troubles determining if this is a androgen deficiency or problems related to thyroid, adrenals, pituitary, prostate, liver etc. All I have is my labs and experimentation with different treatments. Doctors have been of little use. Hoping discussion with other enthusiasts will prove more fruitful. So bring on the stats, symptoms and bloodwork :)

STATS
AGE: 25
HEIGHT: 1m78cm
WAIST: Trim
WEIGHT: 72kg
HAIR: A lot of body hair, enough facial hair to grow a beard
FAT: never had any, now all around waist and thighs
TESTES ACHE: recently since trying GH, Tongkat Ali, etc.
MORNING WOOD: Haven’t had these since I can remember
DIET: Healthy mix of protein carbs and fat - love the sweet stuff but keep it under control.

SYMPTOMS
-Brain Fog 
-Social Withdrawal (really don’t feel like going out tonight)
-Really Excessive Sweating (especially after exercise)
-Exercise intolerance (feeling too tired after exercise, blood pressure drop?)
-No Libido, Hard to maintain EQ
-Gyno
-Serious muscle mass loss
-Adipose fat
-Dark bags under eyes
-Neck temporarily increase in thickness then gone (goiter?)
-Sexual Dysfunction immediately after certain drugs (loss of sensation, maybe blood flow)
-Lack of restorative sleep 

LABS
JANUARY 2014
Leucocytes 5,1 giga/l (4 -10)
Hématies 5,71 tera/l (4,5 - 6,5)
Hemoglobine 15,5 g/dl (13 - 17)
Hematocrite 45,3 % (40 - 54)
VGM 96,2 um3 (80 - 100)
TGMH 32,9 pg  (27 - 32)
CGMH 34,2 g/dl (30 - 35)
Cholesterol 5,88 mmol/l (<5,20)
Triglycerides 1,84 mmol/l (<2,26)  
Cholesterol HDL 1,16 mmol/l (>1,45)
Creatinine 92 μmol/l (59-104)
Iron  21,60 μmol/l (5,83 - 34,50)
Transferrine 2,63 g/l (2 - 3,6) 
C-Reactie Protein <3,0 mg/l (<5,0)
Ferritin 76 ng/ml (30 - 400)
Free T4 15,46 ng/dl (0,94-1,72)
TSH 2,49 μUI/ml (0.27-4.20)
LH 6,0 mUI/ml (1,7 - 8,6)
Prolactin 12 ng/ml (4 -15)
Cortisol 87 ng/ml (62 - 194)*
Calcium 96.4 mg/l (86 - 100)
Phosphore 49,29 mg/l (25 - 44)
Magnesium 21,14 mg/l (16 - 24)
Vitamin D (D2+D3) 27 ng/ml LOW
Testosterone 634 nmol/l (350 -1100)*

*Doctor thought cortisol was kind of low for AM - DHEA 25mg
*Doctor thought test was too low for my age - DHEA 25mg
=improved my EQ but after a while It started stealing away the already little supply of motivation, energy, I had (T -> E2?)

MAY 2014
FSH 8 IU/L (1.4 - 18 )
LH 6.4 IU/L (1-5 - 9.3 )
E2 36.8 pg/ml (11 - 41)
T    577.5 ng /dl (350 -1100)
Free T 489 ng/dl (259-1000)
GH <0.05 L ug/l (0.5 - 4.7 )*
Cortisol 8am blood 930.4 nmol/l (171.00 - 536.00 )*
ACTH 45.7 ng/L (7.2 - 63.3)
IGF-1 267 ng/ml (116-358)

*a cortisol suppression test was done the same week= resulted negative for cushiness syndrome.
*According to doctor GH was abnormally low. We decided to try a month of GH therapy since it addresses same symptoms (helped energy and mental - libido worsened- maybe affected next labs)

JULY 2014
TSH 1.461 mU/L (0.550-4.780) 
T3 1.07 nmol/l (0.9 - 2.79)
T4 78 nmol/l (58 - 151)
FT4 12.93 pmol/l (9 - 20)
FT3 5.14 pmol/l (2.30 - 6.40)
FSH 6.77 IU/L (1.40 -18.10)
LH 4.41 IU/L (1.50-9.30)
Estradiol 28.4  pg/ml (11.4-41.1)
Testosterone 370 pg/ml (230 - 806)*
Na,Sodium 141 nmol/l (133 - 146)
K, Potassium 4.1 mmol/l (3.5 - 5.1)
CL, chloride 104 nmol/l (98 -107)
CO2, carbon dioxide 27 nmol/L (nmol/l)
bUN/Urea Nitrogen 6.8 nmol/l (2.1 - 7.1)
Cr, Creatinine 91 umol/L (55 - 155)
Glucose, Fasting 5.5 nmol/L (3.9 - 5.6)
Ca, Calcium 2.43 nmol/L (2.20 - 2.50)

*after this low test result doctor prescribed Andriol (oral test) 40mg and Chinese herbal concoction.

TREATMENT TRIALS
DHEA: (often used for "adrenal fatigue”) - helped with some of my sexual side-effects in the beginning. but killed little motivation and ambition I had. 
SAINT JOHNS WORT: had to discontinue because immediately worsens sexual dysfunction. (known supplement to help treat hypo HPA)
EURYCOMA LONGIFOLIA: Tried one week after my growth hormone cycle. brought some energy but immediately worsened sexual dysfunction (known supplement test booster)
GROWTH HORMONE - Tried for a month and although gave me much more energy drove my libido (and apparently a lot of my lab values) down.
ANDRIOL - Took for a week and stopped. Did not seem to improve libido aspect and brought on increased lethargy, apathy, etc (High Aromatization?)
RACETAMS - I only used them for one month before my health crash and loved them. now an hour after I take them I receive a numbing sexual dysfunction (too wired - excitocicity?). 

NEXT STEPS
LIVER&SCROTUM ULTRASOUND- Liver to rule out any issues that might be causing the high e2. scrotum to rule out any testicular atrophy (TRT required?)
TAURINE SUPPLEMENTATION - Combination of Phenibut and Racetam’s (although taken separately)could have caused an neurotransmitter imbalance that leads to excitoxicity.
TEMPERATURE TEST - taking temperature upon wake-up to gauge thyroid function.
TEST FOR ZINC DEFECIECNY - low Zinc might explain aromatization from T to E3. Low Zinc also could cause increase prolactin since it’s absence would increase re-uptake of dopamine which has an inverse correlation with prolactin.

OPEN TO ALL SUGGESTIONS :)
 

 

OPTIONAL INFO
Growing up, I had a couple of girlfriends. I never did seem to have the sex-drive I saw in others. Some might say I was a late bloomer and the few relationships I ended up in were most often a result of serendipity rather than my own pursuit. Always more interested in hanging out with my friends. That said, I took pride in my bedroom performance. For this purpose I always used libido enhancing sups and pde5 inhibitors.
SPORTS
Always super sporty. Soccer in my early adolescence and after that I started hitting the gym. These last 2 or 3 years I started increasing the intensity, hour-long jogs and HIIT on my TRX 3 to 4 times a week. fit as a fiddle almost no body fat % and good figure.
MEDICATION/DRUGS
Full-disclosure: i’m no saint. During me teen years I used Accutane to get rid of Acne, Enjoyed exploring every now a then some recreational substances, but was always precautions. When I hit my early 20’s I noticed the beginning of hairloss and a genetic test showed that I carried MPB genetic predisposition. I started doing minoxidil (rogaine) but stayed away from propecia and fina after heeding warnings from many forums of the sides. During this time I would sometimes use Tramadol for pain. In the last six months before my health-crash I was experimenting with some nootropics including piracetam, noopept, choline and phenibut (separately). Some of these for an extra edge mentally, some to aid in increasing libido. It is important to note that the reason I turned to these was to address the fact that my libido was almost nonexistent for as long as I can remember and that I was feeling more and more socially withdrawn



 



#2 Joe Cohen

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Posted 20 August 2014 - 01:26 PM

SYMPTOMS
-Brain Fog 
-Social Withdrawal (really don’t feel like going out tonight)
-Really Excessive Sweating (especially after exercise)
-Exercise intolerance (feeling too tired after exercise, blood pressure drop?)
-No Libido, Hard to maintain EQ
-Gyno
-Serious muscle mass loss
-Adipose fat
-Dark bags under eyes
-Neck temporarily increase in thickness then gone (goiter?)
-Sexual Dysfunction immediately after certain drugs (loss of sensation, maybe blood flow)
-Lack of restorative sleep 

 

The hypothalamus is implicated in all of these symptoms

 

See:

Brain Fog Treatment and Cure Part 1: Diet and Lifestyle

Brain Fog Treatment, Part 2: Supplements


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#3 perplex

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Posted 20 August 2014 - 01:48 PM

Hi Joe,

 

These symptoms are quite vague and generally implicated in many idopathies - adrenals, thyroid, gonads, hypothalamus. Thus, I'm mostly interested in deduction that can be made through hard-evidence, the bloodwork. That said I appreciate your feedback and commend you on all the hardwork you put into to your site (and abs).

 

edit: how would one go about testing hypothalamus damage ?


Edited by perplex, 20 August 2014 - 01:50 PM.


#4 blood

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Posted 24 August 2014 - 08:49 AM

I... commend you on all the hardwork you put into to your site (and abs).

 

 

 

Ha!



#5 perplex

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Posted 01 September 2014 - 05:04 AM

Did a stool test to check for gastric issues and liver function. Doctor says levels were perfect. The search continues...

 

 

 

White Blood Cell: 7.2 (3.5 - 10.5)
hemoglobin: 161 (130-175)
hematocrit: 0.477 (0.380-0.500)
mean cell volume: 91 (81-98)
platelet: 147 (100-400)

neutrophil 0.633 (0.5 - 0.7)
lymphocyte 0.289 (0.2 - 0.4)
monocyte 0.063 (0.020 - 0.1)
eosinophil 0.008 (0 - 0.05)
basophil 0.007 (0-0.02)
NE 4.4 (1.4-7.0)
LY 2.1 (0.7-4.5)
MO 0.5 (0.1-0.8)
EO 0.1 (0.0 - 0.2)
BA 0.1 (0.0 - 0.2)´
Red blood cell: 5.25 (4.09 - 5.72)
Mean corpusular hb: 30.7 (26-34)
MCHC: 337 (315-365)
red cell distribution width RDW 13.1% (11.0-15.00)
Mean platelet volume: 8.6 (6.0-11.0)

TBIL, biliburan total 12.7 umol/l (<17.1)

AlkP: 29L U/L (20-120)
AST: 15 U/L (15-40)
ALT: 12 U/L (10-40)
GGT 20 U/L (11-50)
Total Protein 75 g/L (68-82)
Albumin 48 g/l (35-50)
Bilirubin direct: 3.3 umol/L (0.0 - 8.6)

h.pylori ab: negative
celiac disease test: all negative
food intolerance test: tested 14 different foods and all of them negative

Occult Blood: negative
Ova & parasites: no ova & parasites seen

Stool routine
appearance: formed
color: brown
WBC 0-2/hpf
RBC 0-2/hpf


Edited by perplex, 01 September 2014 - 05:05 AM.


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#6 Huckfinn

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Posted 22 December 2015 - 02:51 PM

..........Any development?



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