14 replies to this topic

[geo12the]

Interesting results although its an unfortunately very small population size:

 

Metab Syndr Relat Disord. 2014 Aug 19. [Epub ahead of print]

Effect of Resveratrol Administration on Metabolic Syndrome, Insulin Sensitivity, and Insulin Secretion.

Méndez-Del Villar M1, González-Ortiz M, Martínez-Abundis E, Pérez-Rubio KG, Lizárraga-Valdez R.

Author information

 

Abstract

Abstract Aim: This study evaluated the effect of resveratrol administration on metabolic syndrome, insulin sensitivity, and insulin secretion. Methods: A randomized, double-blind, placebo-controlled clinical trial was carried out in 24 patients with diagnosis of metabolic syndrome in accordance with the International Diabetes Federation criteria. Glucose and insulin levels were measured after a 75-gram dextrose load. Triglycerides and high-density lipoprotein cholesterol concentrations at baseline were also evaluated. Twelve patients received trans-resveratrol (500 mg) three times per day before meals for 90 days. The remaining 12 patients received placebo at the same dose. The area under the curve (AUC) values of glucose and insulin, total insulin secretion, first-phase of insulin secretion, and insulin sensitivity were calculated. Results: After resveratrol administration, there were significant differences in total weight (94.4±13.2 vs. 90.5±12.3 kg, P=0.007), body mass index (BMI) (35.6±3.2 vs. 34.3±3.0 kg/m2, P=0.006), fat mass (41.2±7.9 vs. 38.8±6.0 kg, P=0.001), and waist circumference (WC) (109±9 vs. 105±10 cm, P=0.004). There were also significant differences in AUC of insulin (48,418±22,707 vs. 26,473±8,273 pmol/L, P=0.003) and insulinogenic index (0.48±0.22 vs. 0.28±0.08, P=0.004). Conclusions: Administration of resveratrol significantly decreases weight, BMI, fat mass, WC, AUC of insulin, and total insulin secretion.

 

[niner]

That's probably why Sirtris/GSK was looking at resveratrol as a diabetes treatment.  That one used 5 grams a day, as I recall, with some formulation tricks to improve bioavailability.  I think that people didn't like the GI side effects from that much resveratrol, or something like that.  It was shelved a long time ago, at any rate.  This paper suggests that reasonable doses do a lot of good.  I wonder how it was formulated?

[hav]

Here's a little more detail...

 

http://clinicaltrial...udy/NCT02114892

 

No mention of anything special in the formulation besides using trans-resveratrol.

 

Howard

 

[to age or not to age]

And, according to Lenny Guarente and David Sinclair, NAD precursors increase resveratrol's effectiveness in

older people, which implies the ability to reap CR effects in older people.  Caloric restriction was seen as not

working in older animals. In a tangental issue, mtor supressor rapamycin, does not have increased longevity

effects if given at an earlier age. This was told to me by Brian Kennedy, CEO of the Buck Institute.  

[APBT]

And, according to Lenny Guarente and David Sinclair, NAD precursors increase resveratrol's effectiveness in

older people, which implies the ability to reap CR effects in older people.  Caloric restriction was seen as not

working in older animals. In a tangental issue, mtor supressor rapamycin, does not have increased longevity

effects if given at an earlier age. This was told to me by Brian Kennedy, CEO of the Buck Institute.  

 

Did they give any clue as to a dosing protocol (range) for NAD precursors and/or resveratrol?  

[to age or not to age]

APBT

Sinclair told me off camera that he believes you would need to consume at least 500mg to a gram per day of NR to see

effects. The amount of resveratrol that does the deal seems to be in the 1.5 gram range.  The paper cited

on longecity says a recent human trial used 500mg of resveratrol 3 times a day, with positive results.  That is interesting

because it makes the distinction between taking one daily large dose or breaking it up between doses. 

I must reiterate that both David and Lenny seem quite certain that these breakthroughs will improve human

health, more certain than they were 7 or 8 years ago.  Where they differ is that Lenny has questions about the power of status quo organizations to slow the process down for monetary reasons.  I will post a new video on this subject, possibly tomorrow.

[malbecman]

 nice find, thanks for posting.  I have usually been a 1x dose/day person.....hmmmm.

[APBT]

to age or not to age

 

Thanks for your quick and informative reply; thus stimulating some follow-up questions.

 

Is it reasonable to infer that David and Lenny both dose NR and resveratrol at the levels you mention?

 

Regarding resveratrol, would a formulation that is micronized with tween, such as the RevGenetics product, which claims an absorption rate of up to 10 times greater than standard resveratrol, allow for a much smaller dose to accomplish the same result?  That is, would 250 mg (at 10X absorption) be the (approximate) equivalent of 2,500 mg of non-micronized/non-tween resveratrol?  Or is this most marketing-hype?

 

For both resveratrol and NR, how crucial is dosing on an empty stomach verses with food for optimal efficacy?   Also, AM verses PM timing based on circadian cycles?

 

I dose resveratrol and NR once daily on an empty stomach upon rising.

 

I’m looking forward to your next video post. 

[TheFountain]

That's probably why Sirtris/GSK was looking at resveratrol as a diabetes treatment.  That one used 5 grams a day, as I recall, with some formulation tricks to improve bioavailability.  I think that people didn't like the GI side effects from that much resveratrol, or something like that.  It was shelved a long time ago, at any rate.  This paper suggests that reasonable doses do a lot of good.  I wonder how it was formulated?

 

 

Did they use knotweed that was not emodin tested for that other study? 

[niner]

 

That's probably why Sirtris/GSK was looking at resveratrol as a diabetes treatment.  That one used 5 grams a day, as I recall, with some formulation tricks to improve bioavailability.  I think that people didn't like the GI side effects from that much resveratrol, or something like that.  It was shelved a long time ago, at any rate.  This paper suggests that reasonable doses do a lot of good.  I wonder how it was formulated?

 

 

Did they use knotweed that was not emodin tested for that other study? 

 

I'm sure that GSK would have been using pure resveratrol.

[TheFountain]

 

 

That's probably why Sirtris/GSK was looking at resveratrol as a diabetes treatment.  That one used 5 grams a day, as I recall, with some formulation tricks to improve bioavailability.  I think that people didn't like the GI side effects from that much resveratrol, or something like that.  It was shelved a long time ago, at any rate.  This paper suggests that reasonable doses do a lot of good.  I wonder how it was formulated?

 

 

Did they use knotweed that was not emodin tested for that other study? 

 

I'm sure that GSK would have been using pure resveratrol.

 

So the gastrointestinal effect was just from too many grams of transresveratrol? 

[bluemoon]

That's probably why Sirtris/GSK was looking at resveratrol as a diabetes treatment. That one used 5 grams a day, as I recall, with some formulation tricks to improve bioavailability. I think that people didn't like the GI side effects from that much resveratrol, or something like that. It was shelved a long time ago, at any rate. This paper suggests that reasonable doses do a lot of good. I wonder how it was formulated?

actually, GSK stopped giving 5000 mg of SRT 501 during a multiple myeloma trial after some patients had kidney problems. Yet the report showed that the number with the problems was statistically no different than what multiple myeloma patients have anyway.

It was also clear that GSK wouldn't be able to make money off of SRT 501 since not much more effective than resveratrol . that trial seemed like a good place to end it. Is this view unlikely?

Any idea why Westphal and his GSK partner tried to sell a version of SRT 501 in six month bulk (everyone else allows one month purchases) before being immediately shut down?
my take is that they wanted to sell it to friends at cost and so let them know they'd have maybe a Very short window to buy a lot of it before that opportunity closed. Is this unlikely?

[niner]

I remember hearing about the kidney problems in the MM trial. I don't know exactly when they pulled the plug on SRT 501, I was just noting that it was trialed in diabetes, and my recollection (possibly hazy/wrong) was that there were GI complaints.

[bluemoon]

I remember hearing about the kidney problems in the MM trial. I don't know exactly when they pulled the plug on SRT 501, I was just noting that it was trialed in diabetes, and my recollection (possibly hazy/wrong) was that there were GI complaints.

I'm quite sure that GSK announced the end of SRT 501 shortly after the mm kidney issue. I think it was here that I read that there was no statistical difference between SRT 501 users and what one would expect from mm patients in general with respect to the kidney problem.

[hav]

Although not directly resveratrol related, here is an interesting paper on a herbal extract MAO inhibitor called Harmine that might be synergistic with resveratrol in moderating diabetes:

 

http://www.ncbi.nlm....les/PMC4303763/

 

Howard