5 replies to this topic

[agwoodliffe]

Some vague literature suggested Ginkgo was useful for treating ADHD. From personal experience, it outperformed standard NRI's.

I initially thought the blocking of certain GABA-A receptors was merely a side effect. Now I've read that other substances useful for the illness (Panax Ginseng, and in particular Oroxylin A) which do exactly the same thing.

I now suspect that classic treatments like Ritalin may exert some beneficial effect by inhibiting this receptor.

 

Or am I just talking a load of bollocks?

[88LS]

I've been exploring the GABA antagonist route on ocassion for the last couple of weeks and I have good things to report.

 

I've tried Wormwood, Sage, Ginkgo, Caffiene, Bacopa, Zinc - alone and mixed together. (Received Muira Puama today and will be trying that still)

 

Positives:

Great motivation/productivity increase 1-3 hours after dosing w/out any sign of ADHD symptoms

Very pleasant mellow, relaxed and well being effect after that for another 1-2 hours after the initial buzz.

 

Negatives:

Slight over-stimulation feeling after dosing for a few hours - key is finding the right combination and dosages of aforementioned GABA Antagonist supps. This usually only occurs if you've overdone it. 

 

I've found Wormwood + Sage (Thujone) and some Bulletproof Coffee in combo to work the best so far. Eager to try out the Muira Puama.

 

[agwoodliffe]

Bacopa & Sage are GABA A antagonists?

[Area-1255]

Bacopa & Sage are GABA A antagonists?

Sage is, bacopa isn't. Bacopa actually may increase GABA by affecting mGLU receptor expression.(1)(2)(3)

 

Ginkgo Biloba and Kudzu are GABA(A) antagonists.

http://www.ncbi.nlm....pubmed/12600688

 

 

 

Eur J Pharmacol. 2003 Mar 7;464(1):1-8. Bilobalide, a sesquiterpene trilactone from Ginkgo biloba, is an antagonist at recombinant alpha1beta2gamma2L GABA(A) receptors.

Huang SH1, Duke RK, Chebib M, Sasaki K, Wada K, Johnston GA.

Author information

 

Abstract

The sesquiterpene trilactone bilobalide is one of the active constituents of the 50:1 Ginkgo biloba leaf extract widely used to enhance memory and learning. Bilobalide was found to antagonise the direct action of gamma-aminobutyric acid (GABA) on recombinant alpha(1)beta(2)gamma(2L) GABA(A) receptors. The effect of bilobalide on the direct action of GABA at alpha(1)beta(2)gamma(2L) GABA(A) receptors expressed in Xenopus laevis oocytes using two-electrode voltage-clamp method was evaluated and compared with the effects of the classical GABA(A) receptor competitive antagonist bicuculline and noncompetitive antagonist picrotoxinin. Bilobalide (IC(50)=4.6+/-0.5 microM) was almost as potent as bicuculline and pictrotoxinin (IC(50)=2.0+/-0.1 and 2.4+/-0.5 microM, respectively) at alpha(1)beta(2)gamma(2L) GABA(A) receptors against 40 microM GABA (GABA EC(50)). While bilobalide and picrotoxinin were clearly noncompetitive antagonists, the potency of bilobalide decreased at high GABA concentrations suggesting a component of competitive antagonism.

 

 

Bacopa may treat epilepsy, and reverse abnormal brain rhythms and receptor activity in epileptics, whereas Ginkgo is PRO EPILEPTIC.

 

http://www.ncbi.nlm....pubmed/19700373

I've been exploring the GABA antagonist route on ocassion for the last couple of weeks and I have good things to report.

 

I've tried Wormwood, Sage, Ginkgo, Caffiene, Bacopa, Zinc - alone and mixed together. (Received Muira Puama today and will be trying that still)

 

Positives:

Great motivation/productivity increase 1-3 hours after dosing w/out any sign of ADHD symptoms

Very pleasant mellow, relaxed and well being effect after that for another 1-2 hours after the initial buzz.

 

Negatives:

Slight over-stimulation feeling after dosing for a few hours - key is finding the right combination and dosages of aforementioned GABA Antagonist supps. This usually only occurs if you've overdone it. 

 

I've found Wormwood + Sage (Thujone) and some Bulletproof Coffee in combo to work the best so far. Eager to try out the Muira Puama.

Muira Puama may be a Dopamine D(1) agonist and Beta-Adrenergic agonist (thus being similar to Clen and Albuterol).

http://www.ncbi.nlm....pubmed/19067380

 

Which is interesting, because muira puama is like a very potent dose of CLEN for me - that's how I would compare it.

So the results of that research are pretty accurate I would say, can't speak for everyone else but...

Edited by Area-1255, 25 August 2014 - 11:57 PM.

[golden1]

doubtful it would be required.. low doses of benzos actually help my mild adhd. 

[Area-1255]

doubtful it would be required.. low doses of benzos actually help my mild adhd. 

ADHD and BiPolar both are linked to either estrogen dominance or copper dominance - or both. 

Low Histamine and High Copper/Estrogen are also linked.

Insulin Resistance can also interfere with normal brain function as well.

Most ADHD sufferer's are either too high in copper or too low. 

best get your copper levels checked.

 

Also 

-GABA,Glutamate and Acetylcholine are usually the deficient NT's in ADHD 

-Histamine stimulates the above, as does NMDA - so this could be another similar said imbalance.