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Icariin - Pharmacodynamics of this Aphrodisiac Explained.

icariin pharmacodynamics aphrodisiac icari horny goat weed

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#1 Area-1255

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Posted 26 August 2014 - 02:59 AM


Thought this might be helpful for those into male sexual health and nutrition and optimal hormone production.

Explains the long-sought Icariin (a component of horny goat weed)  - and it's pharmacological pathways.

 

http://area1255.blog...chanism-of.html


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#2 jroseland

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Posted 09 October 2014 - 05:34 PM

Great article... Does it address Cofactors?



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#3 Area-1255

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Posted 09 October 2014 - 08:01 PM

Great article... Does it address Cofactors?

Co-factors? It only explains the pharmacodynamics/mechanism of action for Icariin, not the other components of horny goat weed.

For Icariin to work properly, you should still be intaking adequate amounts of l-arginine, l-histidine, b-vitamins and vitamin C; all of which are necessary for neurotransmitter and second messenger production. Adding dietary nitrates such as from beets and celery can help enhance the vasodilating effects of Icariin as well.



#4 normalizing

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Posted 09 October 2014 - 08:43 PM

yeah but there is no exact method to extract and test proper and best bioavailable icariin on the market. literally ive tried dozen of brands claiming specific amounts of icariin being in them, yet in mega high doses long periods, nothing. not even a negative effect if someone cares about this. i came to the conclusion that its extremely diffcult to analyse and realize the full potential of this interesting chemical


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#5 Area-1255

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Posted 09 October 2014 - 08:50 PM

yeah but there is no exact method to extract and test proper and best bioavailable icariin on the market. literally ive tried dozen of brands claiming specific amounts of icariin being in them, yet in mega high doses long periods, nothing. not even a negative effect if someone cares about this. i came to the conclusion that its extremely diffcult to analyse and realize the full potential of this interesting chemical

Have you tried world A.B.S / Icariin health brand? aka "Icariin 60"

You can tell by the smell it's pure horny goat weed, and the effects are there.



#6 normalizing

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Posted 09 October 2014 - 08:53 PM

no i tried like 20 various brands sold in various stores. i assume what you refer to is some patented extract that is expensive and found only online. but i dont trust most vendors online...

 

whats the smell like? and does it have really bitter taste? some of the stuff i tried had bitter taste but then again thats not the best indication its good stuff.


Edited by normalizing, 09 October 2014 - 08:54 PM.


#7 Area-1255

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Posted 09 October 2014 - 08:56 PM

no i tried like 20 various brands sold in various stores. i assume what you refer to is some patented extract that is expensive and found only online. but i dont trust most vendors online...

 

whats the smell like? and does it have really bitter taste? some of the stuff i tried had bitter taste but then again thats not the best indication its good stuff.

Smells very pleasant, and store brands rarely are of good enough quality or contain enough real Icariin.



#8 normalizing

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Posted 10 October 2014 - 02:45 AM

70 dollars. interesting you can afford it, good luck then



#9 Area-1255

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Posted 10 October 2014 - 02:24 PM

70 dollars. interesting you can afford it, good luck then

It's worth it, but it can get expensive absolutely.



#10 normalizing

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Posted 10 October 2014 - 07:39 PM

what about liftmode's 50 bucks one on amazon



#11 Logic

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Posted 10 October 2014 - 10:29 PM

I bought the cheap store brand of HGW and it worked well for fixing my knee along with gelatine.

Its good for a number of things besides getting a boner:
http://www.ncbi.nlm....pubmed/22498298

Edited by Logic, 10 October 2014 - 10:31 PM.


#12 Area-1255

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Posted 10 October 2014 - 10:37 PM

I bought the cheap store brand of HGW and it worked well for fixing my knee along with gelatine.

Its good for a number of things besides getting a boner:
http://www.ncbi.nlm....pubmed/22498298

Should be an effective nootropic as well - and can help treat osteoporosis; stimulates osteoclasts / bone formation  rates and prevents breakdown while exerting a simultaneous anti inflammatory effect.


Edited by Area-1255, 10 October 2014 - 10:38 PM.


#13 jroseland

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Posted 11 October 2014 - 06:13 PM

 

Have you tried world A.B.S / Icariin health brand? aka "Icariin 60"

You can tell by the smell it's pure horny goat weed, and the effects are there.

 

What does it smell like?



#14 jroseland

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Posted 11 October 2014 - 06:22 PM

There's seems to be a lot of debate over the dubious Icariin content of supplemental sources, since it's a weed after all is the best solution to getting legit HGW just to grow your own?



#15 Area-1255

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Posted 11 October 2014 - 06:38 PM

 

 

Have you tried world A.B.S / Icariin health brand? aka "Icariin 60"

You can tell by the smell it's pure horny goat weed, and the effects are there.

 

What does it smell like?

 

Hard to explain, like a very pleasant herb or weed...lol

Strong sweet, bitter smell.



#16 Logic

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Posted 11 October 2014 - 07:31 PM

Have you tried world A.B.S / Icariin health brand? aka "Icariin 60"

You can tell by the smell it's pure horny goat weed, and the effects are there.

What does it smell like?


Smell...pht!
I could tell by the insane hardon that woke me up in the middle of the night! :)

Edited by Logic, 11 October 2014 - 07:31 PM.


#17 normalizing

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Posted 11 October 2014 - 07:47 PM

 

 

 

Have you tried world A.B.S / Icariin health brand? aka "Icariin 60"

You can tell by the smell it's pure horny goat weed, and the effects are there.

 

What does it smell like?

 

Hard to explain, like a very pleasant herb or weed...lol

Strong sweet, bitter smell.

 

 

 

that can describe anything

 



#18 Area-1255

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Posted 11 October 2014 - 07:57 PM

 

 

 

Have you tried world A.B.S / Icariin health brand? aka "Icariin 60"

You can tell by the smell it's pure horny goat weed, and the effects are there.

 

What does it smell like?

 


Smell...pht!
I could tell by the insane hardon that woke me up in the middle of the night! :)

 

Haha, or during the day...:D



#19 normalizing

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Posted 13 October 2014 - 09:14 AM

area, try liftmode's 50 buck powder icariin and report. its cheaper and its bigger quantity for cheaper price compared to several capsules for 70



#20 HoldingTheFaith

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Posted 13 October 2014 - 11:35 AM

Am taking horny goat from planetary herbals. Truth is, Ginkgo and Gotu Kola made way more for my lower human horn than this, which helps hardness a bit maybe, whereas these really boosted circulation and the effect was pretty dramatic. In fact I resumed Ginkgo and Maca recently so maybe this horny goat is pure placebo and any improvement comes from Dr Best Ginkgo and Maca.

 

Ironically the Now brand used to give me strong morning wood and is apparently the shittiest icariin around with only 3%. This one doesnt touch my inexistent morning wood.



#21 Area-1255

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Posted 13 October 2014 - 12:32 PM

Am taking horny goat from planetary herbals. Truth is, Ginkgo and Gotu Kola made way more for my lower human horn than this, which helps hardness a bit maybe, whereas these really boosted circulation and the effect was pretty dramatic. In fact I resumed Ginkgo and Maca recently so maybe this horny goat is pure placebo and any improvement comes from Dr Best Ginkgo and Maca.

 

Ironically the Now brand used to give me strong morning wood and is apparently the shittiest icariin around with only 3%. This one doesnt touch my inexistent morning wood.

Well keep in mind there are other compounds besides Icariin...for example flavones that inhibit mao and increase acetylcholine.

So perhaps your effect was based on the psychoactive components...You're telling me that world abs icariin 60 doesn't increase your morning wood?

That's not a good sign though in the first place, lack of morning wood is usually a free t and / or vascular issue.


Edited by Area-1255, 13 October 2014 - 12:33 PM.


#22 HoldingTheFaith

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Posted 13 October 2014 - 04:30 PM

Nah I have just tried two products of Horny Goat aka Icariin, Planetary and Now. Keep in mind I was younger when used NOW. I am sure Icariin 60 is good stuff but I am now using the money for improving my sleep/mood which is more urgent for me.



#23 Logic

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Posted 13 October 2014 - 05:16 PM

I bought the cheap store brand of HGW and it worked well for fixing my knee along with gelatine.

Its good for a number of things besides getting a boner:
http://www.ncbi.nlm....pubmed/22498298


Oops! Wrong link.

Right Link:
http://www.longecity...ndpost&p=565043

#24 Area-1255

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Posted 13 October 2014 - 05:17 PM

Nah I have just tried two products of Horny Goat aka Icariin, Planetary and Now. Keep in mind I was younger when used NOW. I am sure Icariin 60 is good stuff but I am now using the money for improving my sleep/mood which is more urgent for me.

I hear ya, always good sleep and good diet are key points in overall health. This includes hormone levels and ratios.



#25 Area-1255

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Posted 03 December 2014 - 03:29 AM

I've tried liftmode, it's about on the potency of IcariinHealth's but not quite.



#26 Baten

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Posted 30 July 2015 - 10:34 AM

Bit of a thread Resurrection but anyways:

 

- I tried Liftmode's '98% pure' Icariin: this stuff is utterly worthless, I wonder if it's even really a horny goat weed extract. It came with batch analysis from their source, I'm guessing some supplier scammed Lifemode with a bullshit product, that doesn't make it right they are selling a product that isn't what it claims it is. The amazon.com reviews seem to assert my findings.

 

- IcariinHealth's / World A.B.S product works well. Too well, actually. I am running a regimen to boost my testosterone, and noticed on days that I accidentally forgot the 60% HGW product from IcariinHealth, my libido drops. When taking the product on the other hand, the product seems to slowly but noticeably boost libido over time when taking it. I only take 1 cap twice a day and the effect is there.

 

However, the fact that when discontinuing I seem to suffer a sudden and direct withdrawal/downregulation effect, makes me think this product is spiked with a dopamine agonist. Probably not much, but I have my suspicions. No other horny goat weed extract or powder form product I took (and I have taken several) has this effect.


Edited by Baten, 30 July 2015 - 10:35 AM.

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#27 HoldingTheFaith

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Posted 30 July 2015 - 11:16 AM

Bit of a thread Resurrection but anyways:

 

- I tried Liftmode's '98% pure' Icariin: this stuff is utterly worthless, I wonder if it's even really a horny goat weed extract. It came with batch analysis from their source, I'm guessing some supplier scammed Lifemode with a bullshit product, that doesn't make it right they are selling a product that isn't what it claims it is. The amazon.com reviews seem to assert my findings.

 

- IcariinHealth's / World A.B.S product works well. Too well, actually. I am running a regimen to boost my testosterone, and noticed on days that I accidentally forgot the 60% HGW product from IcariinHealth, my libido drops. When taking the product on the other hand, the product seems to slowly but noticeably boost libido over time when taking it. I only take 1 cap twice a day and the effect is there.

 

However, the fact that when discontinuing I seem to suffer a sudden and direct withdrawal/downregulation effect, makes me think this product is spiked with a dopamine agonist. Probably not much, but I have my suspicions. No other horny goat weed extract or powder form product I took (and I have taken several) has this effect.

 

Who knows if this is common with every effective aphrodisiac out there. After all, while on the substance your sexual function is heightened, is logical to expect a feeling of being worse that average when discontinuing...



#28 Baten

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Posted 30 July 2015 - 11:27 AM

Who knows if this is common with every effective aphrodisiac out there. After all, while on the substance your sexual function is heightened, is logical to expect a feeling of being worse that average when discontinuing...

 

 

Perhaps. While your reasoning sounds logical I personally think an effect this pronounced is pretty strange.


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#29 normalizing

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Posted 31 July 2015 - 06:06 AM

wtf, only 60% icarin in their product and it works so well? they are definitely cheating with this one. it makes sense they added other weird shit to fill the rest of the percent there. 

is it really that expensive to send it to private lab and test the stuff? maybe its not that expensive and you can afford it and if you can actually prove it contains some strange shit in there, you can sue them and get some money back.


Edited by normalizing, 31 July 2015 - 06:09 AM.

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#30 Wagner83

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Posted 08 January 2016 - 01:49 PM

I tested the 60 % icariin hgw and here is a review of the product, hopefully  it is useful:

 

First the effects were obvious after 3 weeks on the supplement , I did not always take three caps (suggested dosage) during the first few weeks.

 

Very obvious effects :

 

_ Mood was enhanced.

 

_ Libido was up.

 

_ Confidence and drive  were up .

 

_ Lots of hair in the shower.

 

_ More body hair.

 

_ Erections were maintained easily (even without stimulation).

 

_ Penis was fuller.

 

_ More morning wood.

 

_ Athletic performances were vastly improved. I normally struggle with exercise induced asthma/allergies, and prompt shortness of breath .

At this time I felt like I could finally run properly and reach my potential.

 

_ During my first week off it I noticed the positive effects gradually disappear down to none.

 

Negative effects which could well be attributed to the supplement:

 

_ Very weird sensations happening in the chest  , they were related to breathing (more difficult) and possibly muscles. This happened a few times. It never happened before and has not happened since.

 

_ One week after discontinuing the hgw , I exercised again, and once I was done, at rest, experienced important tacchycardia to the point of unpleasant sensations in the left arm, some tensions in the jaw despite doing nothing.

This had never happened before and has not happened since ( I have not really exercised though).

 

 

What could be attributed to the supplement:

 

_ Testicles shrank once off the hgw, to a very small size, they may have been bigger while on it.

You should know I had never paid too much attention to them before, but now they're bigger (normal?) again.

 

_ It seems I'm losing hair, this could have been triggered by the hgw among other stuff (little tweaks in diet and supplements)

 

 

 

I highly doubt the effects on erections were connected with the pde5 inhibitor role of icariin as I had tried 10 mg cialis a few times with little to no success.

 

It was only a while after discontinuing the hgw that I became aware high dose and/or long term use of hgw is connected with respiratory arrest and tachycardia (although the last one is not 100 % proven from the little I read).

 


Edited by Wagner83, 08 January 2016 - 02:01 PM.






Also tagged with one or more of these keywords: icariin, pharmacodynamics, aphrodisiac icari, horny goat, weed

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