5 replies to this topic

[DbCooper]

Just wondering if anybody has stubbled upon any effective treatment that may help with brain recovery post boxing matches. Ive noticed the military and the NFL has been dumbing money into trying to understand and treat TBIs. I assume any treatment that would minimize damage while enhancing recovery would be applicable. 

 

In the study  below they mention depletion of Magnesium as well as NMDA antagonists may be of benefit in treating acute head injury.

 

http://www.sciencema.../4906/798.short

[niner]

As far as things that you can actually get your hands on,  I'd say C60oo, NAC, or MitoQ

[APBT]

I’d add nicotinamide riboside (Niagen) to the list as a potential candidate: http://hpnsupplements.com/store/nr/

 

Also, see this article:  From October 2013 LEF magazine, pages 95 - 99: http://www.lef.org/H...&source=CVJ300E

[Darryl]

Much of the damage following brain trauma is due to prolonged NF-κB mediated inflammation.

 

Over 1000 compounds are now known to inhibit NF-κB. Here's a very abbreviated list:

 

 

[6]-gingerol - fresh ginger

20(S)-protopanaxatriol - ginseng (Panax ginseng)

amentoflavone - Ginkgo biloba, Hypericum perforatum (St. John’s Wort)

alpha-lipoic acid

anandamide - cocoa, endogenous anandamide elevated by acetaminophen

anethole - anise, fennel, liquorice, star anise

apigenin - parsley, celery and chamomile tea

astragaloside IV - Astragalus propinquus (huáng qí)

betulinic acid - rosemary

black raspberry extracts

black rice extract

blue honey suckle extract

capsaicin - chili peppers

cardamomin & cardamonin - cardamon

carnosol - rosemary, sage

curcumin - tumeric

dehydroascorbic acid - oxidized vitamin C

docosahexaenoic acid (DHA) - fish oil, algal oil

emodin - rhubarb, buckthorn and Japanese knotweed

epigallocatechin-3-gallate - green tea

equol - intestinal metabolite of daidzein from soy

gallic acid - chestnut, blackberry, cocoa, walnut, amla, red wine

gamma-tocotrienol - form of Vitamin E especially in annatto, rice, and palm oils

genipin - gardenia fruit extract

genistein - soy isoflavone, also in fava beans

glabridin - licorice

kahweol - coffee

PGG - yeast

phenethyl isothiocyanate - cruciferous vegetables

phytic acid - sesame seeds, pinto beans, flax seed, brazilnuts, soy, almonds, walnut, peanut, oats, brown rice, corn, hazelnut, chickpeas

piperine - black pepper

quercetin - red and yellow onions, tea, wine, apples, cranberries, buckwheat, beans

rosmarinic acid - rosemary, oregano, sage, thyme and peppermint

sesquiterpene lactones - Chinese star anise

silibinin - milk thistle extract

silymarin - milk thistle extract

stinging nettle extracts

sulforaphane - cruciferous vegetables (esp broccoli, cabbage, cauliflower, brussels sprouts)

taurine & niacin

theaflavin - black tea

ursolic acid - apples (especially peels), basil, bilberries, cranberries, elder flower, peppermint, rosemary, lavender, oregano, thyme, hawthorn, and prunes

vitamin D

whithanolides - ashwagandha

 

acetaminophen

aspirin

atorvastatin

benfotiamine

ibuprofen

nicotine

NSAIDs

zinc

 

Personally, I'd:

• regularly eat lots of phytochemical-rich plants and avoid excess arachidonic acid (many meats) and linoleic acid (some vegetable oils). This should also aid training soreness.
• supplement regularly with fish oil/algal EPA, vitamin D and zinc,
• in the hours preceeding and following a fight, consume raw broccoli/broccoli sprouts and dark roast coffee, and take non-aspirin NSAIDs like ibuprofen, curcumin, green tea extract, fisetin, and rosemary extract supplements

 

 

 

 

[niner]

What I'd like to know about those nfkb inhibitors is are any of them effective in vivo?  It's pretty easy to inhibit an enzyme in a test tube when the compound is at high concentration, much harder to reach that concentration in the body, in the same compartment as the nfkb, and for a long enough time to be effective.  This is where natural products usually flame out.

[Darryl]

There are certainly issues with absorbing significant amounts of all the polyphenols, and getting enough past the liver, to have meaningful effects, but there are plenty of studies which demonstrate in vivo (in lab animal) or ex vivo (in humans) NF-κB inhibition. And for short duration events and their immediate aftermath its practical to get absorbed doses in to the micromolar plasma range where in vitro and in vivo effects are seen.  

 

I suspect the greater problem is identifying NF-κB inhibitors which pass the blood-brain barrier. There are at least animal studies demonstrating BBB passage by sulforaphane (broccoli), carnosol/carnosic acid (rosemary), fisetin, curcumin, and EGCG (green tea), most commonly demonstrating oral doses prevent or reduce hypoxic–ischemic injury, which itself is partly mediated by NF-κB activation.

 

I suspect for the majority of these plant hormetins, NF-κB inhibition is secondary to Nrf2 activation. The regulatory crosstalk is known, and the lists of natural Nrf2 activators and NF-κB inhibitors mostly overlap.

 

Is there any advantage in taking all five (with dark roast coffee as a smorgasborg of poorly characterized melanoidins which are more effective NF-κB inhibitors than in light roast), since they all seem to hit the same pathways? Perhaps not - its mostly a matter of insurance, should one or several be poorly absorbed, fall prey to first-pass liver metabolism, or not pass through the BBB in adequate quantity. With the exception of EGCG (which has caused liver disorders when abused for weight loss), they all appear fairly safe.

 

The regular fish oil (EPA/DHA), vitamin D, zinc, and fight day NSAID likely have no difficulty with the BBB.

 

Satoh, Takumi, et al. "Carnosic acid, a catechol‐type electrophilic compound, protects neurons both in vitro and in vivo through activation of the Keap1/Nrf2 pathway via S‐alkylation of targeted cysteines on Keap1." Journal of neurochemistry 104.4 (2008): 1116-1131.

Maher, Pamela. "Modulation of multiple pathways involved in the maintenance of neuronal function during aging by fisetin." Genes & nutrition 4.4 (2009): 297-307.

...you'll find dozens of papers on sulforaphane, curcumin & EGCG and in vivo brain outcomes.

Sandberg, Mats, et al. "NRF2-regulation in brain health and disease: Implication of cerebral inflammation." Neuropharmacology 79 (2014): 298-306.

Edited by Darryl, 29 August 2014 - 05:53 AM.