3 replies to this topic

[Kewell357]

Can Uridine decrease amphetamine tolerance if taken together?

 

It is said to upregulate dopamine receptors. And if so, by that logic, then can Phenylpiracetam and CDP Choline  do the same?

[Omega 3 Snake Oil]

I'd like to know about this as well. I have high dopamine (took selegiline under rx for years) and am wondering if it's safe to try uridine.

[vader]

I feel absolutely nothing from increasing uridine levels...

[gamesguru]

No.  Uridine promotes a "potassium-evoked dopamine release," a primarily presynaptic mechanism.  It works by downregulating autoreceptor activity (presynaptic receptors which reduce and modulate NT release).  But in the case of amphetamine abuse, a gross downregulation is already the status quo on both the presynaptic and postsynaptic sites.  That's why we actually see better results from glutamate (memantine) or dopamine antagonists