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[Logic]

Interleukin-6 (IL-6)  is needed for:

• Regenerative and anti-inflammatory activities.
• Regulation of the immune system, nervous system and metabolism.
• protection against various infectious diseases.
• etc.

When Interlukin-6 signalling goes wrong it leads to the inflammatory diseases of old age:

• Atherosclerosis and coronary artery disease.
• Arthritis.
• Crohn Disease.
• Most cancers.
• etc.

Treatment with sgp130Fc seems to block IL-6 signalling downstream of the good effects buy blocking trans-signaling only.
Note that the natural protein sgp130 has the same effect

Transsignaling of Interleukin-6 Crucially Contributes to Atherosclerosis in Mice.
http://atvb.ahajourn.../2/281.full.pdf

IL-6 Trans-Signaling via the Soluble IL-6 Receptor: Importance for the Pro-Inflammatory Activities of IL-6.
http://www.ijbs.com/v08p1237.htm

Therapeutic strategies for the clinical blockade of IL-6/gp130 signalling.
http://www.jci.org/articles/view/57158

"...IL-6 is the master cytokine mediator of inflammation and immunity. Recently, IL-6 has also been found to be the principle biomarker for cellular senescence. Specifically, senescent cells secrete the senescence associated secretory phenotype (SASP), which is a group of over 70 cytokines secreted by senescent cells. This explains why the two phenomena, aging and cancer, are chronologically linked. IL-6 can generate paracrine and autocrine feedback loops, thereby activating nearby cells to become cancerous and self-activating the production of more IL-6. This in turn induces apoptosis-resistance by blocking genes required for programmed cell death..."
http://www.anti-agin...-aging-in-2013/


The Company Developing sgp130Fc:
http://www.conaris.d...l/about_us.html

The natural protein:
http://www.rndsystem...lts.aspx?m=1533

I am posting this info in supps as people will probably want to synth this sgp130Fc protein?

[Logic]

Epigallocatechin-3-gallate inhibits IL-6 synthesis and suppresses transsignaling by enhancing soluble gp130 production.

"...epigallocatechin-3-gallate (EGCG), an anti-inflammatory compound found in green tea, inhibits IL-1β–induced IL-6 production and transsignaling in RA synovial fibroblasts by inducing alternative splicing of gp130 mRNA, resulting in enhanced sgp130 production. Results from in vivo studies using a rat adjuvant-induced arthritis model showed specific inhibition of IL-6 levels in the serum and joints of EGCG-treated rats by 28% and 40%, respectively, with concomitant amelioration of rat adjuvant-induced arthritis. We also observed a marked decrease in membrane-bound gp130 protein expression in the joint homogenates of the EGCG-treated group. In contrast, quantitative RT-PCR showed that the gp130/IL-6Rα mRNA ratio increased by ∼2-fold, suggesting a possible mechanism of sgp130 activation by EGCG...
 
...To study in vivo modulation of IL-6 by EGCG in rats, a daily i.p. injection of EGCG (100 mg/kg) based on an earlier study, which corresponds to 960 mg of human equivalent dose..."
http://www.pnas.org/...5/38/14692.full