194 replies to this topic

[SerP3nT]

ok this all make sense now! THANKS JAY!!!!

[SerP3nT]

[Jason30]

 

I said it can increase histamine elimination, that means it can increase the breakdown of histamine..but ANY form of folate will ALSO increase copper excretion and act as a direct copper antagonist - which means TECHNICALLY, any form could, be merit of that property, cause histamine release..but, you should stick to the original/regular 'ol folate as an insurance policy!

 

Is that because copper is needed for the DAO enzym?

[SerP3nT]

i believe so. area is away i guess for the summer in another state, he'll be back soon. 

 

 

I said it can increase histamine elimination, that means it can increase the breakdown of histamine..but ANY form of folate will ALSO increase copper excretion and act as a direct copper antagonist - which means TECHNICALLY, any form could, be merit of that property, cause histamine release..but, you should stick to the original/regular 'ol folate as an insurance policy!

 

Is that because copper is needed for the DAO enzym?

 

 

[Area-1255]

 

 

I said it can increase histamine elimination, that means it can increase the breakdown of histamine..but ANY form of folate will ALSO increase copper excretion and act as a direct copper antagonist - which means TECHNICALLY, any form could, be merit of that property, cause histamine release..but, you should stick to the original/regular 'ol folate as an insurance policy!

 

Is that because copper is needed for the DAO enzym?

 

Yes, and it is involved in creating methyl groups which affect histamine and other biogenic amines / amino acid neurotransmitters.

[Dichotohmy]

Any insight into overmethylation and treating that via histaminergic upregulation via H3 blockade, or vica versa, treating the histaminergic deficiency via correcting the overmethylation condition and/or copper imbalance? Intuitively, it seems both approaches would help, but correcting the overmethylation issues seems like more of a "cure" if you will. Pitosilant is considered an inverse agonist, so is it safe to say that antagonism and inverse agonism accomplish the same thing with the H3 receptor?

 

For the record, zinc gluconate and niacinamide are helpful, but far from magic, while I'm sensitive to psychostimulants, methylfolate, methylcobalamine and even B-50 complexes are they are way overstimulating in a dirty, adrenaline-fueled way, and make me worse with prolonged use.

Edited by Dichotohmy, 11 September 2015 - 09:38 PM.

[Area-1255]

Any insight into overmethylation and treating that via histaminergic upregulation via H3 blockade, or vica versa, treating the histaminergic deficiency via correcting the overmethylation condition and/or copper imbalance? Intuitively, it seems both approaches would help, but correcting the overmethylation issues seems like more of a "cure" if you will.

 

For the record, zinc gluconate and niacinamide are helpful, but far from magic, while I'm sensitive to psychostimulants, methylfolate, methylcobalamine and even B-50 complexes are they are way overstimulating in a dirty, adrenaline-fueled way, and make me worse with prolonged use.

Folate, B12 and Niacin in fairly high doses will help..as well as MANGANESE (not magnesium) and Zinc. Also - a 7-day or 14-day cycle of high-dose Vitamin C ( v 1400 %RDA) will kick it off fast but the histamine will drop first.. While the C is in your system; but ascorbic acid rapidly eliminates Copper if used in the above proportions and combinations with other minerals/nutrients.

 

THT.co's Pitolisant will help as well as long-term use of alpha-2-blockers such as Rauwolscine or Yohimbine...if you really want to go crazy about neuronal histamine you can also take a 5-HT1A antagonist such as WAY 100 635 which is also sold @ THT.co .  (second page of "Cognitive Enhancement").

[Dichotohmy]

 

Folate, B12 and Niacin in fairly high doses will help..as well as MANGANESE (not magnesium) and Zinc. Also - a 7-day or 14-day cycle of high-dose Vitamin C ( v 1400 %RDA) will kick it off fast but the histamine will drop first.. While the C is in your system; but ascorbic acid rapidly eliminates Copper if used in the above proportions and combinations with other minerals/nutrients.

 

THT.co's Pitolisant will help as well as long-term use of alpha-2-blockers such as Rauwolscine or Yohimbine...if you really want to go crazy about neuronal histamine you can also take a 5-HT1A antagonist such as WAY 100 635 which is also sold @ THT.co .  (second page of "Cognitive Enhancement").

 

 

I guess my question was if just H3 reverse agonism/antagonism would have the same efficacy as using all of those usual supplements in regards to treating overmethylation and excess copper, and thus correcting histamine wasting and slowing down the excessive monoamines in the CNS.

 

I'm also not opposed to being the guinea pig who tries both strategies at once. This thread is pretty eye-opening, so thanks.

 

 

 

 

[Area-1255]

 

 

Folate, B12 and Niacin in fairly high doses will help..as well as MANGANESE (not magnesium) and Zinc. Also - a 7-day or 14-day cycle of high-dose Vitamin C ( v 1400 %RDA) will kick it off fast but the histamine will drop first.. While the C is in your system; but ascorbic acid rapidly eliminates Copper if used in the above proportions and combinations with other minerals/nutrients.

 

THT.co's Pitolisant will help as well as long-term use of alpha-2-blockers such as Rauwolscine or Yohimbine...if you really want to go crazy about neuronal histamine you can also take a 5-HT1A antagonist such as WAY 100 635 which is also sold @ THT.co .  (second page of "Cognitive Enhancement").

 

 

I guess my question was if just H3 reverse agonism/antagonism would have the same efficacy as using all of those usual supplements in regards to treating overmethylation and excess copper, and thus correcting histamine wasting and slowing down the excessive monoamines in the CNS.

 

I'm also not opposed to being the guinea pig who tries both strategies at once. This thread is pretty eye-opening, so thanks.

 

Yes, it's about as efficacious .  Although, it really depends - if you have tons of copper you still need to deal with that first!

If your histamine is low because of other unexplained reasons that DON'T have to do with Copper accumulation then an H3 antagonist and drinking coffee throughout the day would help.

[Area-1255]

EFFECT OF COPPER STATUS ON BRAIN NEUROTRANSMITTER METABOLISM IN THE LAMB

 

Effect of zinc, copper and glucocorticoids on metallothionein levels of cultured neurons and astrocytes from rat brain

 

Effect of copper loading on various tissue enzymes and brain monoamines in the rat ☆

 

http://citeseerx.ist...p=rep1&type=pdf

Edited by Area-1255, 14 September 2015 - 08:04 PM.

[Area-1255]

 

Br J Urol. 1995 Feb;75(2):220-4.

The role of histamine in human penile erection.

Cará AM1, Lopes-Martins RA, Antunes E, Nahoum CR, De Nucci G.

Author information

 

Abstract

OBJECTIVE:

To investigate the relaxant action of histamine on human corpus cavernosum in vitro and the erectile response caused by the intracavernous injection of histamine in patients with psychogenic impotence.

PATIENTS AND METHODS:

Human corpus cavernosum (HCC) tissue was cut into strips of approximately 2 cm and suspended in a cascade bioassay. The strips were then superfused with oxygenated and warmed Krebs solution and precontracted with noradrenaline (3 microM). Glyceryl trinitrate, acetylcholine and histamine were injected as a single bolus in the absence or in the presence of mepyramine and cimetidine. For the in vivo studies, histamine (30-60 micrograms) was injected intracavernously as a single bolus into the right corpus cavernosum 1 cm from the balamo-preputial sulcus. Similar protocols were carried out for papaverine (50 mg). The erectile response was divided into four grades: no response, tumescence, partial and full erection.

RESULTS:

In vitro studies demonstrated that histamine (3-100 micrograms) caused dose-dependent relaxation of the HCC strips which was significantly inhibited by cimetidine (5-10 microM). The histamine H1 receptor antagonist mepyramine (1 microM) potentiated histamine-induced relaxation. The co-infusion of both mepyramine and cimetidine did not abolish histamine-induced relaxation. When injected intracavernously in humans, histamine (30 micrograms) caused full erection in 13% of the patients, whereas 87% had partial erection or tumescence. A higher dose of histamine (60 micrograms) caused full erection in 26% of the patients and 74% had partial erection or tumescence. Papaverine induced full erection in the majority of patients (66%). In contrast to papaverine, the duration of erection induced by histamine was markedly shorter (mean 200 and 6.5 min, respectively). The penile erections induced by papaverine were associated with complications such as pain, haematoma and priapism. Histamine did not induce any complications. Treatment of eight male patients with psychogenic impotence with the histamine H1 receptor antagonist astemizol (10 mg orally once daily for 1 week) did not affect histamine-induced erectile responses.

CONCLUSION:

These results indicate that histamine may play a role in human penile erection. The erection-promoting action of histamine is probably due to H2 receptor activation, although another histamine receptor, possibly H3, also seems to be involved. This study suggests that histamine could be a valuable tool in the diagnosis of erectile dysfunction.

PMID:   7850330   [PubMed - indexed for MEDLINE]

 

Edited by Area-1255, 19 September 2015 - 01:51 AM.

[Area-1255]

Histamine involved in modafanil-wakefulness action.

 

 

Neurosci Lett. 2003 Mar 20;339(2):143-6.

Modafinil increases histamine release in the anterior hypothalamus of rats.

Ishizuka T1, Sakamoto Y, Sakurai T, Yamatodani A.

Author information

 

Abstract

Modafinil, (RS)-2-(Diphenylmethylsulfinyl)acetamide, is a well known wake promoting drug used for the treatment of narcolepsy. We investigated the effect of modafinil on the hypothalamic histamine release in the anesthetized rat using in vivo microdialysis. Modafinil (150 mg/kg, i.p.) increased histamine release by 150% of the basal release. The intracerebroventricular (i.c.v.) injection of modafinil (1 nmol) also increased histamine release, however, when modafinil (1 nmol) was injected directly into the tuberomammillary nucleus, a limited region where cell bodies of the histaminergic neurons are located, histamine release was not altered. These observations suggest that modafinil may promote waking via the activation of the histaminergic system, although it does not appear to be a direct pharmacological target of modafinil.

PMID:   12614915   [PubMed - indexed for MEDLINE]

 

Edited by Area-1255, 21 September 2015 - 07:04 PM.

[Area-1255]

Histamine H3 receptor-mediated inhibition of depolarization-induced, dopamine D1 receptor-dependent release of [3H]-γ-aminobutyric acid from rat striatal slices

[Area-1255]

Progesterone has an impact on histamine levels; including brain histamine as well...DHEA seems to raise it while Progesterone *generally* decreases it.

http://www.area1255....aining-how.html

[Area-1255]

PROGESTERONE AND THE BRAIN - LINK TO BRAIN NEURONAL HISTAMINE AND DOPAMINE