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Could Vitamin D increase Klotho levels ?

klotho longevity

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#1 mitomutant

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Posted 12 September 2014 - 01:15 PM


http://rockstarresea...-klotho-levels/

 

 

 

It turns out that lots of people get their klotho levels increased as a side-effect of taking prescription forms of “activated” vitamin D (VDRAs) for chronic kidney disease (CKD). But there’s no reason to wait until you’re almost dying and need dialysis to start benefiting from this knowledge. Instead, this implies that taking something like 0.25 mcg/day of Calcitriol or 1 mcg/day of Paricalcitol right now for someone without the beneficial KL-VS variant of the KL gene might actually give a huge longevity and IQ boost. The intelligence boost is so large, that if this new study is right and the effects of klotho are at all acute, you should be able to measure it directly with something like quantified mind or perhaps even just raw introspection. Hopefully lots of researchers follows up on the most obvious implications of these two currently unconnected research findings and investigate activated vitamin D as a way to boost longevity and cognition in the 80% of the population lacking functional, klotho producing KL-VS genes.

 

Would regular oral Vitamin D3 produce the same effects ? After all, people with CKD take "activated" vitamind D because their kidneys cannot build it.

 


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#2 niner

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Posted 13 September 2014 - 01:41 PM

It's conceivable that you'd see some of the longevity effects, I think less likely that you'd get an IQ boost. The reason that I think this is because I suspect there's a developmental component to it, and once development is done, it's done. The longevity effect is said to be related to calcium homeostasis that is maintained in older age, rather than lost, and it seems more probable that you could affect this pharmacologically. I could be wrong on both counts though, as a) I'm speculating, and b) I have the low IQ TT version of Rs9536314, a trait I share with Eliezer Yudkowsky. (so much for that...) FWIW, my wife has the desirable GT version of the aforementioned Klotho gene, and she is smart as hell and comes from a very long lived family.
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