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Human Serum Albumin to get peptides into cells? Activate P53 etc.

cancerp53 intracellular

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#1 Logic

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Posted 15 September 2014 - 02:24 PM


"...Use of proteins and peptides as therapeutic agents has become increasingly provocative in recent years. These biologically active molecules have many advantages over small molecule drugs including higher specificity and decreased potential to cause adverse effects. The average number of new peptide drug candidates has grown steadily from an average of 1.2 per year in the 1970’s to 16.8 per year so far in the 2000’s [1]. Among these promising candidates, however, few are known to bind intracellular proteins, thus ignoring a vast reservoir of potential targets. An efficient cell penetrating technology remains one of the major obstacles to peptide drug application. Here we propose a delivery technology using recombinant human serum albumin (rHSA) to promote cellular penetration of both a therapeutic peptide and small molecule drug. In addition to prolonging serum stability, this novel strategy is capable of facilitating simultaneous intracellular delivery of two therapeutic agents, each with distinct but complimentary mechanisms, to promote a synergistic therapeutic response for the treatment of a variety of diseases....

...The novel technology presented in this paper utilizes the long-chain fatty acid transportation properties of HSA with its aptitude as a genetically modifiable protein to deliver a highly specific peptide to an intracellular target..."

http://www.plosone.o...al.pone.0080926

It seems that this tech can be used to get any C-terminal fused peptides into cells where they can target specific genes!?  Now that sounds like something worth looking into!?






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