I recently gave up on a stack which included Uridine Monophosphate because it was just making me apathetic, lethargic, unmotivated and depressed. I tried all sort of dosing regimens from 50mg to 200mg both sublingually and orally, dosing in the evening and the morning, nothing worked.
I found this thread on reddit, which matches my experience perfectly: http://readditing.co...comments/2ctjmq
I also experienced difficulty getting out of bed after dosing UMP the night before, even at low doses of 50 - 100mg.
I have also noticed that if I take more than one 250mg dose of CDP Choline in a day, I start to feel unpleasant shortly after taking the second dose, which is no doubt related. That said I am now wondering if even one dose of CDP Choline could have been having subtle amotivational and depressive effects on me in the past.
Anyway - could anyone shed any light on the reason that some people react badly to Uridine?
Although it seems I am not alone in my experience, it seems that this reaction is still slightly less common that the positive experience that many people have with it.
I would obviously like to think it is just that my brain is already maximally effective at utilising uridine from dietary sources such that supplementation is counter-productive. 
But obviously it is likely something else.
Edited by Xenthide, 16 September 2014 - 10:31 AM.
