13 replies to this topic

[lotyorg]

I got my Modafinil officially with prescription, so this is 100% legit and NO generica.

 

Before I stacked

1x 1,5 scoop FOCUS XT

with 1-2x daily 1600 mg Piracetam

 

worked good in motivation and concentration.

 

I thought Moda will open the limits.

 

Started with 50mg, later that day the other 50mg. No effect.

 

Next day 100mg in morning, mid day other 100mg. No to mild effect.

 

Why am I so immun to the effect and should I stack it with Piracetam? I have not experienced any side effects right until now.

Edited by lotyorg, 16 September 2014 - 07:49 PM.

[jerrybusey]

http://www.snpedia.c...ndex.php/Rs4680

 

TL;DR: Your genetics.

[lotyorg]

http://www.snpedia.c...ndex.php/Rs4680

 

TL;DR: Your genetics.

 

I don't hope so...
 

Okay, third day.

 

Woke up after 4h of sleep, resting heart rate is little higher but was low before.

Does this mean it's working or only to some degree? Will try on empty stomach today.

Edited by lotyorg, 17 September 2014 - 04:56 AM.

[ModaMinds]

Many people are genetically-disinclined to the effects of modafinil. That said, make sure your body is in an ideal state to take it. Empty stomach, good blood flow (do some morning cardio), and never take it when you're still tired.

[Mr Matsubayashi]

http://www.snpedia.c...ndex.php/Rs4680

 

TL;DR: Your genetics.

 

I'm (A;A) and found modafinil highly effective contrary to genetic evidence. Unfortunately my liver can not tolerate this drug.

[FW900]

The lack of effect can't be surmised to a simple "not working because of genetics. If you have a higher body mass, you will need a higher dosage at least according to mg/kg dosage calculations. OP, take 400mg at once and then determine if it lacks effect. 50mg really is miniscule. Taking it the next day usually will diminish the initial feeling of modafinil.

 

No offense to you, but your doctor is a retard if he told you to take it twice a day. Modafinil has one of the longest half-lives of a prescribed psychostimulants therefore does not need to be redosed. And unlike amphetamines, modafinil maintains a steady effect throughout the day, it does not have 'peaks' in effectiveness like amphetamine does. There is no need to take it twice a day unless you want to be sleep deprived, you're better off taking a larger dose earlier on.

 

I'd get rid of the FOCUS XT, sounds like some kind of scoopable powder containing indiscriminate amounts of caffeine per serving which in combination with modafinil and or other stimulants probably isn't wise.

[lotyorg]

Thanks so far.

 

I do bodybuilding 6-7 days a week for almost 2 years straight, am quite lean (around 8-10% bf) and muscular at 156 lbs / 5'9. Diet is 40/20/40 (carbs/fats/protein) at slight deficit.

 

400 mg sounds a lot, but will test with 200mg on an empty stomach next morning and will go from there.

Edited by lotyorg, 17 September 2014 - 12:39 PM.

[Area-1255]

I've only noticed significant effects of 150 mg Moda + PER DOSE. Twice a day.

Using it with caffeine helps and Piracetam should not interfere.

Helps if you eat more protein throughout the day as well.

Specifically Chicken and other proteins with a stimulatory effect would help amplify Moda's effects.

Edited by Area-1255, 17 September 2014 - 09:21 PM.

[ModaMinds]

The lack of effect can't be surmised to a simple "not working because of genetics. If you have a higher body mass, you will need a higher dosage at least according to mg/kg dosage calculations. OP, take 400mg at once and then determine if it lacks effect. 50mg really is miniscule. Taking it the next day usually will diminish the initial feeling of modafinil.

 

No offense to you, but your doctor is a retard if he told you to take it twice a day. Modafinil has one of the longest half-lives of a prescribed psychostimulants therefore does not need to be redosed. And unlike amphetamines, modafinil maintains a steady effect throughout the day, it does not have 'peaks' in effectiveness like amphetamine does. There is no need to take it twice a day unless you want to be sleep deprived, you're better off taking a larger dose earlier on.

 

I'd get rid of the FOCUS XT, sounds like some kind of scoopable powder containing indiscriminate amounts of caffeine per serving which in combination with modafinil and or other stimulants probably isn't wise.

 

Taking 400 mg at once for a new user is probably the worst recommendation I've ever seen. 50 mg and 100 mg are common starting doses to see if people react in any way to modafinil; usually 100 mg provides some sort of effect even if it's not at its maximum potential. Whereas 400 mg is the highest possible recommended dose and only if you need it; doses of 400 mg and above often accentuate side effects and there have been many reports of it resulting in the complete opposite of its intended effects.

Edited by ModaMinds, 18 September 2014 - 02:21 AM.

[FW900]

 

The lack of effect can't be surmised to a simple "not working because of genetics. If you have a higher body mass, you will need a higher dosage at least according to mg/kg dosage calculations. OP, take 400mg at once and then determine if it lacks effect. 50mg really is miniscule. Taking it the next day usually will diminish the initial feeling of modafinil.

 

No offense to you, but your doctor is a retard if he told you to take it twice a day. Modafinil has one of the longest half-lives of a prescribed psychostimulants therefore does not need to be redosed. And unlike amphetamines, modafinil maintains a steady effect throughout the day, it does not have 'peaks' in effectiveness like amphetamine does. There is no need to take it twice a day unless you want to be sleep deprived, you're better off taking a larger dose earlier on.

 

I'd get rid of the FOCUS XT, sounds like some kind of scoopable powder containing indiscriminate amounts of caffeine per serving which in combination with modafinil and or other stimulants probably isn't wise.

 

Taking 400 mg at once for a new user is probably the worst recommendation I've ever seen. 50 mg and 100 mg are common starting doses to see if people react in any way to modafinil; usually 100 mg provides some sort of effect even if it's not at its maximum potential. Whereas 400 mg is the highest possible recommended dose and only if you need it; doses of 400 mg and above often accentuate side effects and there have been many reports of it resulting in the complete opposite of its intended effects.

 

 

I don't know where to begin. First, you're incorrect, 800mg is the highest recommended prescribed dose (US guidelines) and the LD50 is on par with caffeine. He said he had a prescription for modafinil, and he is based in Germany according to his profile location. The only way one can be prescribed modafinil in most Eurozone countries is to have narcolepsy. Since he possibly has narcolepsy or at least excessive daytime sleepiness, a higher dose is warranted.

 

I wouldn't recommend that large of a dose for the average person, especially starting. But considering the OP didn't respond to even 200 mg in a day, titrating another 200 mg is not that large of an increase. I fail to see how suggesting 200 additional milligrams can be the "worst recommendation" you've ever seen.

 

Also modafinil is a racemic mixture. The other isomer of modafinil is useless and only has a half life of roughly 4 hours. There are people who take 800mg of the active isomer, armodafinil to no ill effect. So a 200mg titration is even less of a jump.

 

I stand by my recommendation.

[lotyorg]

I don't know where to begin. First, you're incorrect, 800mg is the highest recommended prescribed dose (US guidelines) and the LD50 is on par with caffeine. He said he had a prescription for modafinil, and he is based in Germany according to his profile location. The only way one can be prescribed modafinil in most Eurozone countries is to have narcolepsy. Since he possibly has narcolepsy or at least excessive daytime sleepiness, a higher dose is warranted.

 

I wouldn't recommend that large of a dose for the average person, especially starting. But considering the OP didn't respond to even 200 mg in a day, titrating another 200 mg is not that large of an increase. I fail to see how suggesting 200 additional milligrams can be the "worst recommendation" you've ever seen.

 

Also modafinil is a racemic mixture. The other isomer of modafinil is useless and only has a half life of roughly 4 hours. There are people who take 800mg of the active isomer, armodafinil to no ill effect. So a 200mg titration is even less of a jump.

 

I stand by my recommendation.

 

 

I only stated that I got it legitimately with a prescription, not that I was under supervision of an doctor or correctly dignosed.

 

After trying 1x 200mg this morning, I am still unsatisfied and thinking to switch back to Piracetam before I run into any side effects of Modafinil.

Edited by lotyorg, 18 September 2014 - 10:22 AM.

[FW900]

 

I don't know where to begin. First, you're incorrect, 800mg is the highest recommended prescribed dose (US guidelines) and the LD50 is on par with caffeine. He said he had a prescription for modafinil, and he is based in Germany according to his profile location. The only way one can be prescribed modafinil in most Eurozone countries is to have narcolepsy. Since he possibly has narcolepsy or at least excessive daytime sleepiness, a higher dose is warranted.

 

I wouldn't recommend that large of a dose for the average person, especially starting. But considering the OP didn't respond to even 200 mg in a day, titrating another 200 mg is not that large of an increase. I fail to see how suggesting 200 additional milligrams can be the "worst recommendation" you've ever seen.

 

Also modafinil is a racemic mixture. The other isomer of modafinil is useless and only has a half life of roughly 4 hours. There are people who take 800mg of the active isomer, armodafinil to no ill effect. So a 200mg titration is even less of a jump.

 

I stand by my recommendation.

 

 

I only stated that I got it legitimately with a prescription, not that I was under supervision of an doctor or correctly dignosed.

 

After trying 1x 200mg this morning, I am still unsatisfied and thinking to switch back to Piracetam before I run into any side effects of Modafinil.

 

 

Well if you do not need it for a sleep disorder and you're looking for the nootropic dose, 400mg is likely excessive.

 

As a last resort, you could always see if the doctor can switch you to armodafinil, which should be stronger than the number equivalent dose of modafinil.
 

[ModaMinds]

 

 

The lack of effect can't be surmised to a simple "not working because of genetics. If you have a higher body mass, you will need a higher dosage at least according to mg/kg dosage calculations. OP, take 400mg at once and then determine if it lacks effect. 50mg really is miniscule. Taking it the next day usually will diminish the initial feeling of modafinil.

 

No offense to you, but your doctor is a retard if he told you to take it twice a day. Modafinil has one of the longest half-lives of a prescribed psychostimulants therefore does not need to be redosed. And unlike amphetamines, modafinil maintains a steady effect throughout the day, it does not have 'peaks' in effectiveness like amphetamine does. There is no need to take it twice a day unless you want to be sleep deprived, you're better off taking a larger dose earlier on.

 

I'd get rid of the FOCUS XT, sounds like some kind of scoopable powder containing indiscriminate amounts of caffeine per serving which in combination with modafinil and or other stimulants probably isn't wise.

 

Taking 400 mg at once for a new user is probably the worst recommendation I've ever seen. 50 mg and 100 mg are common starting doses to see if people react in any way to modafinil; usually 100 mg provides some sort of effect even if it's not at its maximum potential. Whereas 400 mg is the highest possible recommended dose and only if you need it; doses of 400 mg and above often accentuate side effects and there have been many reports of it resulting in the complete opposite of its intended effects.

 

 

I don't know where to begin. First, you're incorrect, 800mg is the highest recommended prescribed dose (US guidelines) and the LD50 is on par with caffeine. He said he had a prescription for modafinil, and he is based in Germany according to his profile location. The only way one can be prescribed modafinil in most Eurozone countries is to have narcolepsy. Since he possibly has narcolepsy or at least excessive daytime sleepiness, a higher dose is warranted.

 

I wouldn't recommend that large of a dose for the average person, especially starting. But considering the OP didn't respond to even 200 mg in a day, titrating another 200 mg is not that large of an increase. I fail to see how suggesting 200 additional milligrams can be the "worst recommendation" you've ever seen.

 

Also modafinil is a racemic mixture. The other isomer of modafinil is useless and only has a half life of roughly 4 hours. There are people who take 800mg of the active isomer, armodafinil to no ill effect. So a 200mg titration is even less of a jump.

 

I stand by my recommendation.

 

 

US guidelines indicate a 200 mg standard dose and a 400 mg maximum dose, with very very few patients taking 600 mg and 800 mg. Clinic trials have shown there is little to no benefit of a 400 mg dose over a 200 mg dose including those with narcolepsy, and there are numerous first-hand accounts from users reporting 400 mg results in excessive tiredness, headaches, nausea, and other accentuated side effects whereas 200 mg provides the desired vigilance. While there are patients who take 800 mg per day, it is naive and irresponsible to recommend someone jump to an abnormally-high dose when the drug has already proven to not react as expected and they have not yet even taken a full regular dose at once in the proper manner. Keep in mind that while off-label uses for modafinil include stimulation and focus at 200 mg, the drug is specifcially designed for people with narcolepsy, so there is absolutely no logical reason to presume he needs a higher than average dose if he has the condition the drug was intended to be used for. You can stand by your recommendation, but we stand by the factual evidence countering your opinion.

Edited by ModaMinds, 18 September 2014 - 06:22 PM.

[FW900]

 

US guidelines indicate a 200 mg standard dose and a 400 mg maximum dose, with very very few patients taking 600 mg and 800 mg. Clinic trials have shown there is little to no benefit of a 400 mg dose over a 200 mg dose including those with narcolepsy, and there are numerous first-hand accounts from users reporting 400 mg results in excessive tiredness, headaches, nausea, and other accentuated side effects whereas 200 mg provides the desired vigilance. While there are patients who take 800 mg per day, it is naive and irresponsible to recommend someone jump to an abnormally-high dose when the drug has already proven to not react as expected and they have not yet even taken a full regular dose at once in the proper manner. Keep in mind that while off-label uses for modafinil include stimulation and focus at 200 mg, the drug is specifcially designed for people with narcolepsy, so there is absolutely no logical reason to presume he needs a higher than average dose if he has the condition the drug was intended to be used for. You can stand by your recommendation, but we stand by the factual evidence countering your opinion.

 

 

I stand corrected on the 800mg dose guidelines. Also, 800mg+ dosages appear to elevate blood pressure and heart rate.

 

Recommending an additional 200mg is neither naive nor irresponsible. Once again, the logic behind suggesting a higher dose was because the lower dosages are not showing efficacy! The first thing a doctor does if a patient is not responding to a medicine is up the dosage, especially considering no side effects were reported at the previous dosage. If he had side effects, my opinion would be different.

 

He experiences "no effect" from it, even at 200mg. It's either he stops taking it completely or tries a higher dose before doing so. I'm suggesting the latter.

 

Just because the dose is outside your use and comfort range does not make it dangerous. You mention, "there are numerous first hand accounts of tiredness, headaches, nausea from users reporting 400mg dosages". May I state that most medical literature typically lists 400mg dosages as "well-tolerated" (see link) in study participants. Well-tolerated, meaning that side effects occur in only a fraction of the sample population. Also, even if he did experience these symptoms, they are not severe and would only be temporary. If this was tachycardia  and hypertension, this would be a different story.

 

The "desired vigilance" and "average dose" of 200mg makes no sense in relation toward someone who is a non-responder at these dosages. I always advocate taking the lowest necessary dosage to prevent tolerance. This being said, 400mg appears to be hugely better than for treating daytime sleepiness than a 200mg dose.

 

 

 

Dose Effects of Modafinil in Sustaining Wakefulness in Narcolepsy Patients With Residual Evening Sleepiness

All four modafinil dosing regimens improved the overall clinical condition (CGI-C) after 3 weeks of treatment, relative to baseline (F3). With respect to late-afternoon/evening sleepiness, the proportion of patients rated as "much improved" or "very much improved" was highest among those receiving the modafinil 600-mg and 400-mg split-dose regimens: 92% and 80%, respectively, compared with 70% of patients in the 400-mg once-daily group and 27% of patients in the 200-mg once-daily group. The proportion of patients rated as being at least "improved" was significantly higher in the modafinil 600-mg split-dose (100%), 400-mg split-dose (90%) and the 400-mg once-daily (91%) groups than in the 200-mg once-daily group (55%, p<0.01).

→ source (external link)

 

You've stated that your post is based in "factual evidence" which implies that mine were not. You've implied cautionary statements, (e.g., calling a dose "abnormal") without backing them up. If anything my aforementioned posts were implicitly more factual than your own. I simply gave advice, there was no need to assume it to be reckless, debase it, and turn it into an argument.