11 replies to this topic

[Absent]

Warning: Do not try this unless you are very confident in your health and your ability to manage yourself. Megadosing like this is experimental and potentially risky, if you decide to follow suit, be very mindful of the risks you are taking. I am not afraid of any permanent damage I may cause. I have a very resilient mind and have done large-doses binges of far worse drugs and managed to recover. I have a very good sense of my mind and my body and how to influence them. 

 

Yes I am aware of the potential liver side effects of Adrafinil. I am willing to take the risk seeing as I never drink or do any other intoxicants anyways. If possible in the future I may switch to Modafinil.

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In this experiment I will be taking strict adherence to a few healthy practices - eating healthy, maintaining a healthy sleep cycle, and going running 30 minutes each day.

 

 

The Purpose of this Experiment: To see how high of a dose I can tolerate without mental enhancing effects dimenishing. If there is one thing that has been made clear to me in my research, it is that not everyone reacts to Modafinil/Adrafinil the same. One persons 50mg dose may be another persons 400mg dose. I have read several accounts of individuals taking 800-1,200mg+ daily without much problem, other than rebound tiredness for a few days if they suddenly stop. I am curious to test these claims, and if possible, go far beyond them. I suspect rebound tiredness may be avoided if strict adherence to sleep schedule is kept.

 

Method: After these first few days, I will be increasing my dose by 100mg daily, and continue to do so until uncomfortable effects begin to emerge. When those effects do emerge, I will dial the dose back just a hair to the most recent comfortable dose, and see how long I can manage that for. 

 

 

Log:

- 2 days ago, I took a 300mg dose in the morning, and went about the day, nothing unusual, except a notably building wakefulness. The last time I took Adrafinil the mental effects didn't really start to pop until day 2 or 3. 

- 1 day ago, upon waking I actually noticed the sleep quality was higher than the first time I trialed. The first time I trialed I would be increasingly more tired each day I woke up. On this day I took 350mg

- [9/27/2014] Today, my rest seems to be increasing in quality, and I am reaching a new level of mental awareness/alertness that I had not hit on the 200mg doses the first time I trialed. Today, I took 400mg. 

 

- Tomorrow I will be taking 500mg, and going about my day as usual.

 

 

[Introspecta]

I trialed Adrafinil a few times. First time I bought it from Newstar and needed at least 500mgs to notice much effects. I recently aquired a sample from awake brain and 300mgs had me much more jittery than I hoped. They mix it with Ginkgo Biloba which supposedly increases effects. Either its better quality or the Ginkgo because its now close to 20 hours later and I'm still awake but 6 hours after dosing I dosed 1.5mgs of Semax

 

You don't get tolerance when your dosing it everday? I noticed I was getting tolerant by the 4th day.

[Invariant]

I disagree with the "more is better" mindset, but since you've made up your mind, maybe you can have a look at milk thistle. It's said to have liver protective properties, although I'm not too familiar with the research myself. Have a look at it, it may save your poor liver

[Absent]

I trialed Adrafinil a few times. First time I bought it from Newstar and needed at least 500mgs to notice much effects. I recently aquired a sample from awake brain and 300mgs had me much more jittery than I hoped. They mix it with Ginkgo Biloba which supposedly increases effects. Either its better quality or the Ginkgo because its now close to 20 hours later and I'm still awake but 6 hours after dosing I dosed 1.5mgs of Semax

 

You don't get tolerance when your dosing it everday? I noticed I was getting tolerant by the 4th day.

 

Experience and reports have suggested that there isn't much of a tolerance with Modafinil and its derivatives, or that there is actually a reverse-tolerance, where the effects build over a period ideas. One individual claimed there is an initial tolerance, but after that initial build up, it stops.

 

So far I can't notice any tolerance. Modafinil/Adrafinil has a very unique effect for me. It not only keeps me alert but floods my mind with a unique form of mental energy without any jitteriness.

 

 

I disagree with the "more is better" mindset, but since you've made up your mind, maybe you can have a look at milk thistle. It's said to have liver protective properties, although I'm not too familiar with the research myself. Have a look at it, it may save your poor liver 

 

 

I'm calling it an experiment for a reason. It would absolutely silly if you adopted a "more is better" mindset for everything, and it would be equally ridiculous if you disregarded this mindset as potentially useful for some compounds. With nootropics and other compounds, we must understand that they all behave extremely differently, and we must use that understanding to exploit the compound to the best of its ability. 

 

I do not take nootropics to heal some deficit within me.... that is taken care of by living a healthy lifestyle. I take nootropics for the sole purpose of enhancing my mind to the greatest extent that I possibly can. I understand many people on the forum do not take this approach, but many do. The only way to do this effectively is to simply experiment and find what works for our purposes and what doesn't. 

 

I've had great success in the past with doing this same procedure for a number of other nootropics and drugs. For some it does not work so great, for others it works fantastically. For example, Piracetam and Fish Oil taken together in a 1:1 ratio produces phenomenal mental effects, even at extremes such as 30-50 grams of each. But at that dose, the Fish Oil starts to have some negative effects on skin healing speeds.

[Invariant]

You say sensible things and I agree that one needs to experiment to find what works. Your experiment will probably achieve the stated goal, which is "To see how high of a dose I can tolerate without mental enhancing effects dimenishing.", but I do not think this goal makes sense. This question has some academic interest, but as an individual you should aim for the dose that provides maximum performance enhancement while being safe and tolerable, for the duration you want to be using the substance. If an increase in the dose does not yield further benefits, why increase the dose and thereby increase the risk of (serious, potentially lasting) side effects?

 

I think your current experiment will not provide a lot of useful information for establishing an effective and sustainable dose level (although it may be an exciting project for you). The reason is that with such a rapid dose escalation, you will hit the point of adverse effects before you have learned what dose level gives acceptable performance enhancement while also being sustainable.

[chemicalambrosia]

Keep an eye on your skin quality. Adrafinil caused some serious body acne for me. Its definitely something I wouldn't want to megadose and take on a continual basis. It might be an individual thing, but it seems to be very hard on my body.

[Absent]

I'm at 500mg today. I feel I really need to get my hands on Modafinil. For me it feels like the Adrafinil doesn't really kick in until at least 8+ hours after I take it. At which point, around night time, I get supreme mental enhancement, a much higher mental agility/data processing, unlike any other stimulant I've done, others of which have just made me feel "speedy"

 

 

This question has some academic interest, but as an individual you should aim for the dose that provides maximum performance enhancement while being safe and tolerable, for the duration you want to be using the substance. If an increase in the dose does not yield further benefits, why increase the dose and thereby increase the risk of (serious, potentially lasting) side effects?

 

 

I think that was stating the obvious and given. I was naturally working with the assumption that as long as I increase the dosage the effects will increase (as modafinil/adrafinil has a very distinct drug-type behavior similar to amphetamines, rather than compared to a nootropic/supplement). You are right, if a 300mg dose does the exact same thing as a 1000mg dose, effect wise, then there is no reason to keep going higher. When I spoke of finding the upper limit, I meant finding the upper limit of the mental effects/enhancement that can be reached without negatives arising. 

 

 

Keep an eye on your skin quality. Adrafinil caused some serious body acne for me. Its definitely something I wouldn't want to megadose and take on a continual basis. It might be an individual thing, but it seems to be very hard on my body.

 

 

I will be on the look out. I've naturally had acne prone skin, but I've had my face totally taken care of with one regime I've found. The only other acne issue I've had is with regard to minor, but spread out back acne of my upper back and upper arms, and this never seems to go away no matter how good my diet is, no matter how careful I treat my skin, or anything. I will definitely take note if anything "out of the ordinary" begins to arise.

 

[8bitmore]

 

I'm at 500mg today. I feel I really need to get my hands on Modafinil. For me it feels like the Adrafinil doesn't really kick in until at least 8+ hours after I take it. At which point, around night time, I get supreme mental enhancement [...]

 

 

If this is really as on the clock as you seem to imply then why not try taking the Adrafinil at nighttime? Wake up to "supreme mental enhancement"

 

[Absent]

 

 

I'm at 500mg today. I feel I really need to get my hands on Modafinil. For me it feels like the Adrafinil doesn't really kick in until at least 8+ hours after I take it. At which point, around night time, I get supreme mental enhancement [...]

 

 

If this is really as on the clock as you seem to imply then why not try taking the Adrafinil at nighttime? Wake up to "supreme mental enhancement"

 

I think I tried that my first cycle and I don't think my sleep quality appreciated it very much (I woke up, ate, was dead tired for 12+ hours inspite of taking a 250mg dose in the morning). Though, I suspect that my brain also needs time to adapt its sleep habits and adjust to compensate for the heightened awareness/energy. 

 

I will try taking some Adrafinil in the evening tonight with some Melatonin to see what happens. Last night I fell asleep fairly easily. 

 

One other theory I have is this: I read that Modafinil is a Norepinephrine Reuptake inhibitor, and by this mechanism it can cause Long-Term Potentiation of the Norepinephrine circuits (and a bit of Dopamine). This could be an explanation to why many people report a reverse tolerance with Modafinil  the longer they take it, and why many people report that they retain many habits and cognitive patterns after stopping their usage. It would also explain why the effect seems to "build" throughout the day for me. My brain always is really slow to start up in the morning if my sleep was poor. 

 

When I take large doses of Caffeine or Adderall in the morning, it picks me up pretty quickly (within minutes). When I take Adrafinil I can feel the effect gradually building throughout the day, constantly intensifying up till the end of the day. This could be that my brain is gradually producing more Norepinephrine and the levels are building in the synapses. It could also explain the Eugeroics effects in staving off hunger-based fatigue, since the brain cannot as easily clear the Norepinephrine levels from the synapses. It is also worth noting that there is a very stark difference between Norepinephrine based concentration/focus and Dopaine based focus.

Edited by Siro, 29 September 2014 - 09:57 PM.

[8bitmore]

 

 

 

I'm at 500mg today. I feel I really need to get my hands on Modafinil. For me it feels like the Adrafinil doesn't really kick in until at least 8+ hours after I take it. At which point, around night time, I get supreme mental enhancement [...]

 

If this is really as on the clock as you seem to imply then why not try taking the Adrafinil at nighttime? Wake up to "supreme mental enhancement"

 

I think I tried that my first cycle and I don't think my sleep quality appreciated it very much (I woke up, ate, was dead tired for 12+ hours inspite of taking a 250mg dose in the morning). Though, I suspect that my brain also needs time to adapt its sleep habits and adjust to compensate for the heightened awareness/energy. 

 

I will try taking some Adrafinil in the evening tonight with some Melatonin to see what happens. Last night I fell asleep fairly easily.  [...]

 

Interesting with the Adrafinil/Melatonin combo, seems unlikely to work though when you have already confirmed that doing the Adrafinil on its own does NOT do wonder for your sleep. All same: be interesting to hear how it went! Also a quick thank-you for your older postings on Iodine, I am taking conservative bi-daily dose now as a result of reading through your's and other longecity member's posts on the subject - definitely perks my metabolism up.
 

[Absent]

Why would Adrafinil/Melatonin not work? For me Melatonin helps my mind ease into sleep.... Adrafinil doesn't directly prevent me from falling to sleep but it can make it more difficult to relax, where as melatonin definitely assists in relaxing. 

 

Sorry I haven't replied in a while, had some trouble in life with some things, had to stop around 600mg unexpectedly, but the experience shall now continue.

[jroseland]

Update? How long did you megadose Adrafinil?