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A Review of What Can Be Done Today About Brain Aging


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Posted 30 September 2014 - 11:38 AM


Little can be done today to stem the tide of age-related degeneration, at least in comparison to the potential rejuvenation treatments of tomorrow. It remains the case that regular moderate exercise and calorie restriction have more solid, proven effectiveness over the long term than any available treatment or enhancement technologies for basically healthy people. Hence you find them right at the top of this open access review on the subject of present methods used to somewhat slow age-related cognitive decline. To see any greater impact than this, we will need new and more effective medical technologies that treat the root causes of aging, and the sooner these treatments are developed the better:

Brain aging and aging-related neurodegenerative disorders are major health challenges faced by modern societies. Brain aging is associated with cognitive and functional decline and represents the favourable background for the onset and development of dementia. Brain aging is associated with early and subtle anatomo-functional physiological changes that often precede the appearance of clinical signs of cognitive decline. Neuroimaging approaches unveiled the functional correlates of these alterations and helped in the identification of therapeutic targets that can be potentially useful in counteracting age-dependent cognitive decline.

Advancements in fluorescent microscopy, molecular biology, and electrophysiological techniques have helped to unravel many molecular determinants of neuronal plasticity. These technical advancements, along with the notion that the aging brain retains the capacity to reorganize its morphological and functional architecture, have promoted strong interest and leaps forward in the knowledge of the physiology of the aging brain and aging-related cognitive processes as well as in the exploration of strategies aimed at enhancing or maintaining cognitive skills in the elderly.

A growing body of evidence supports the notion that cognitive stimulation and aerobic training can preserve and enhance operational skills in elderly individuals as well as reduce the incidence of dementia. This review aims at providing an extensive and critical overview of the most recent data that support the efficacy of non-pharmacological and pharmacological interventions aimed at enhancing cognition and brain plasticity in healthy elderly individuals as well as delaying the cognitive decline associated with dementia.

Link: http://dx.doi.org/10...nsys.2014.00153


View the full article at FightAging




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