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Resv. increases bone density in obese men-clinical trial

resveratrol in vivo human

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#1 malbecman

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Posted 20 October 2014 - 03:34 PM


 
Interesting results.......150 mg or 1 gram/day dosages.
 
 
J Clin Endocrinol Metab. 2014 Oct 16:jc20142799. [Epub ahead of print]
Resveratrol Increases Bone Mineral Density and Bone Alkaline Phosphatase in Obese Men: A Randomized Placebo-Controlled Trial.
Abstract

Context: Metabolic syndrome (MetS) is associated with low-grade inflammation, which may harmfully affect bone. Resveratrol (RSV) possesses anti-inflammatory properties, and rodent studies suggest bone protective effects. Objective: This study sought to evaluate effects of RSV treatment on bone in men with MetS. Setting and Design: The study was conducted at Aarhus University Hospital as a randomized, double-blinded, placebo-controlled trial assessing changes in bone turnover markers, bone mineral density (BMD), and geometry. Participants: The study population comprised 74 middle-aged obese men with MetS recruited from the general community, of which 66 completed all visits. Mean age of participants was 49.3 ± 6.3 years and mean body mass index was 33.7 ± 3.6 kg/m2. Intervention: Oral treatment with 1,000 mg RSV (RSVhigh), 150mg RSV (RSVlow), or placebo daily for 16 weeks. Main Outcome Measure: Prespecified primary endpoint was change in bone alkaline phosphatase (BAP). Results: BAP increased dose dependently with RSV (R = 0.471, P < .001), resulting in a significantly greater increase in BAP in the RSVhigh group compared with placebo at all time-points (week 4, 16.4 ± 4.2%, P < .001; week 8, 16.5 ± 4.1%, P < .001; week 16, 15.2 ± 3.7%, P < .001). Lumbar spine trabecular volumetric bone mineral density (LS vBMDtrab) also increased dose dependently with RSV (R = 0.268, P = .036), with a significant increase of 2.6 ± 1.3% in the RSVhigh group compared with placebo (P = .043). In addition, changes in BAP and LS vBMDtrab were positively correlated (R = 0.281, P = .027). No consistent changes were detected in bone density at the hip. Conclusions: Our data suggest that high-dose RSV supplementation positively affects bone, primarily by stimulating formation or mineralization. Future studies of longer duration comprising populations at risk of osteoporosis are needed to confirm these results.

PMID: 25322274
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#2 maggie67

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Posted 28 October 2014 - 04:56 AM

Interesting but where to find the fluxome resveratrol from yeast fermentation that was used in the study?



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#3 maxwatt

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Posted 18 November 2014 - 03:19 PM

Any 98 or 99% purity resveratrol should give similar results.



#4 maggie67

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Posted 30 November 2014 - 08:33 AM

Thanks Maxwatt.I'll give the RevGen supp a shot for female osteoporosis!


Edited by maggie67, 30 November 2014 - 08:36 AM.


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#5 Vastmandana

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Posted 30 November 2014 - 08:40 AM

thanks for posting.... glad I started at 1g/day!







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