Damn I´ve totally overseen this thread..
Yes its depression but a certain, You must imagine that some medicinic terms dont describe accurately a condition.
e.g. Autism or like here Depression.
Some people feel down, are sad, the world is grey.
Others feel total lack of pleasure aphaptic & etc.
Both is depression but the causes are different like: inflammation, disturbtion of second messengers, too much or(?) too less Glutamate, too much Glucocorticoids, low Dopamine, Adrenaline and/or Serotonine (monoamines)
I would try 5-ht (2c) inhibitors like Trazodone or better Mirtazapine, perhaps Buspirone(5-ht1a agonist among others) or passionflower (mao-a inhibitor).
If this fails, then something Dopaminergic like
So I highly doubt that this has anything to do with the gut.
People: Havent You never experienced a pain when You lost someone or something very bad happened ?
In my case its the same region in the chest like when Youre in love... but the opposite; a pain and a hole. No emotions when this started; no life, no pleasure at all, just the pain..
As said, I have/had this too. Its better but still there.
The possible cause of this is a long story and I´m still not sure what caused this.. will tell If You want to know.
I had a few months before this depression (which lasts allready for 2 Years) a other depression.
This was caused by stress and "bad emotions" which triggered something like a trauma but it relvealed afer 1-2 Months and with total relaxation.
The lasting one appeared step by step when I´ve taken Ethylphenidate and eventually peresisted.
See:
http://www.longecity...ethylphenidate/
Here are some infos about what helped and what not:
A few terms about what worsens it:
calcium channel blockade(lavender), Adrenergic activation, Glucocorticoids, 5-ht2c activation, mao-a and -b (perhaps due to adrenaline elevation) Alcohol, even weed but helped for the first depression, too much coffee, NMDA activation (Sarcosine + aspargic acid+ calcium ; Testforce 2)
This helped transiently:
Cigarettes, Mirtazapine (just for the first depression which was somewhat similair), amitryptiline, Piracetam was mixed but ok, Dan Shen (chinese salvia), Cerebrolysin (for several months untill due to stress it reapeared)
Huperzin A, St. Johns wort, Sodium Benzoate
If You want more informations, possible causes and treatment ideas, then look into:
http://www.longecity...e-3#entry694781
http://www.longecity...gh/#entry713700
http://www.longecity...inrepair-topic/
http://www.longecity...esting-effects/
http://www.longecity...pression/page-3
Be careful with SSRI´s and SNRI´s, parkinson medication i.e. Dopamine agonists as well with other medications and perhaps herbs.
The first can cause Post Ssri Sexual Disorder(PSSD) = a for years lasting impotence and asexuallity.
The second can cause DAWS dopamine agonist withdrawal syndrome = hard addicted and perhaps a denervation in the mesolibic dopamine fibres
The latter can cause anything = Hermorhage due to mixing varoius stuff, epigenetic changes like in the case of one guy here on longecity who took Topiramate( though hes the only one who experienced this)
There were a few reports of Piracetam and Noopept caused brain fog and other things which seemingly perresisted