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Ketosis as calorie restriction

ketogenic diet cancer

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8 replies to this topic

#1 nushu

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Posted 26 October 2014 - 03:34 AM


I'm a week into ketogenic eating, I feel great and I have little desire for food. Ketosis is effectily CR. I get 70% of my calories from saturated fats, 25-30g of carb a day. One thing you need to know if starting this, get at least 5g of salt a day and plenty of
K+ (green veg).

Edited by nushu, 26 October 2014 - 03:35 AM.

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#2 drew_ab

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Posted 28 October 2014 - 02:23 AM

Are you concerned about the atherogenic properties of saturated fat?



#3 nushu

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Posted 28 October 2014 - 12:58 PM

No. I know a woman in her mid 50s who's been in ketosis for the last 28 years, she looks good and is healthy. I'll see if I can get her to join here. Carbs are fat more damaging to the body long term than good saturated fats. Take a look at this study
http://www.ncbi.nlm....les/PMC2716748/
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#4 Saintor

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Posted 03 November 2014 - 12:47 AM

Where do you get your proteins?

 

"at least 5g of salt a day" is insane.



#5 nushu

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Posted 03 November 2014 - 08:14 PM

[quote name="Saintor" post="696100" timestamp="1414975676"]

Where do you get your proteins?

"at least 5g of salt a day" is insane.[/quote

Meat, eggs, cheese. Why is salt insane? Show me evidence that it's harmful.
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#6 dankis

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Posted 03 November 2014 - 10:40 PM

Diuretic effect of VLC diet fades after keto adaptation. About month into this fatty lifestyle and gobbling that amount of salt probably won't be necessary.


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#7 noots6494

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Posted 06 November 2014 - 02:45 AM

I'll just leave this link here

 

http://plantpositive...al-is-good.html

 

I tried a ketogenic diet of basically protein powder, oil, and supplements earlier this year and really came to hate it. After the "induction," I didn't notice any increase in energy that couldn't be attributed to placebo and I theorize the energy for the folks who do swear by it comes from an increase in IGF-1 by all the animal protein the diet emphasizes, which definitely isn't a good thing long-term.



#8 lucid

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Posted 19 November 2014 - 07:28 AM

I love the topic of Ketosis as a calorie restriction memetic, so I must weigh in.

 

I was in ketosis for about 6 months. I recorded my blood work monthly and saw a DRAMATIC improvement in my triglycerides and a modest improvement in HDL & LDL despite the enormous ammounts of saturated fats.

 

But I didn't feel great. Excercise is difficult while in Ketosis, plus i wasn't super excited about the food after a while.

 

Anyways, if you look at metabolic pathways, fat intake doesnt turn any / many of the nutrient sensing pathways which deactivate CR mechanisms. This makes sense because your body uses its own fat while starving. So this seems viable, but I don't think it is proven out in any animal studies though I would be interested to know of any.

 

This is also relavent to bodybuilding while in CR, because it is one of the few mechanisms that might allow the body to stay calorie neutral while having longevity pathways turned on. That said, ketogenic diets don't create anabolic signalling that is required for muscle growth, so BCAA's are probably required. (Good news is that BCAA's act down stream of the point where major longevity pathways (FOXO) are activated.

 

Also,

I'll just leave this link here

 

http://plantpositive...al-is-good.html

 

I tried a ketogenic diet of basically protein powder, oil, and supplements earlier this year and really came to hate it. After the "induction," I didn't notice any increase in energy that couldn't be attributed to placebo and I theorize the energy for the folks who do swear by it comes from an increase in IGF-1 by all the animal protein the diet emphasizes, which definitely isn't a good thing long-term.

 

Its difficult to stay in ketosis with significant protien intake. Needs to be ~50g. Don't know how much protien you are taking.

 

Also Also,

Its not clear that you actually need to be in Ketosis to have pro-longevity pathways turned on. Hell, its not even clear (except in metabolic pathway charts) that ketosis turns on pro-longevity pathways.



#9 Chupo

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Posted 03 December 2014 - 10:11 AM


 

Also Also,

Its not clear that you actually need to be in Ketosis to have pro-longevity pathways turned on. Hell, its not even clear (except in metabolic pathway charts) that ketosis turns on pro-longevity pathways.

 

Ketones do turn on longevity pathways even when added as a supplement to a normal diet. Longevity research regarding ketones is just beginning and ketones have recently been proven to extend the life of worms.   

 

 

The ketone body beta-hydroxybutyrate (βHB) is a histone deacetylase (HDAC) inhibitor and has been shown to be protective in many disease models, but its effects on aging are not well studied. Therefore we determined the effect of βHB supplementation on the lifespan of C. elegans nematodes. βHB supplementation extended mean lifespan by approximately 20%. RNAi knockdown of HDACs hda-2 or hda-3 also increased lifespan and further prevented βHB-mediated lifespan extension. βHB-mediated lifespan extension required the DAF-16/FOXO and SKN-1/Nrf longevity pathways, the sirtuin SIR-2.1, and the AMP kinase subunit AAK-2. βHB did not extend lifespan in a genetic model of dietary restriction indicating that βHB is likely functioning through a similar mechanism. βHB addition also upregulated βHB dehydrogenase activity and increased oxygen consumption in the worms. RNAi knockdown of F55E10.6, a short chain dehydrogenase and SKN-1 target gene, prevented the increased lifespan and βHB dehydrogenase activity induced by βHB addition, suggesting that F55E10.6 functions as an inducible βHB dehydrogenase. Furthermore, βHB supplementation increased worm thermotolerance and partially prevented glucose toxicity. It also delayed Alzheimer's amyloid-beta toxicity and decreased Parkinson's alpha-synuclein aggregation. The results indicate that D-βHB extends lifespan through inhibiting HDACs and through the activation of conserved stress response pathways

 

Now, let the mouse studies begin!
 


Edited by Chupo, 03 December 2014 - 10:14 AM.






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