Leucine increases SIRT1, prevents mitochondrial dysfunction
#1
Posted 27 October 2014 - 03:12 AM
#2
Posted 28 October 2014 - 01:10 PM
I have been wondering about this paradox too... Leucine is the aa that is most potent in activating mTOR and activity in this pathway should decrease lifespan. Seems that the SRT induction one gets from Lecine can compensate sufficiently for the increased mTOR signaling. Still, it would be interesting to see the effects of a high leucine diet would be in combination with mTOR inhibition, e.g. rapamycin...
#3
Posted 30 October 2014 - 05:18 PM
I have been wondering about this paradox too... Leucine is the aa that is most potent in activating mTOR and activity in this pathway should decrease lifespan. Seems that the SRT induction one gets from Lecine can compensate sufficiently for the increased mTOR signaling. Still, it would be interesting to see the effects of a high leucine diet would be in combination with mTOR inhibition, e.g. rapamycin...
http://www.ncbi.nlm....pubmed/22028412
Maybe activating mTOR inhibits eNOS expression, and that's the reason for a reduced lifespan?
http://www.plosone.o...al.pone.0031155
"Calorie restriction (CR) extends lifespans of model organisms ranging from yeast to mammals [1]–[4], and many groups have focused on understanding how this dietary intervention acts mechanistically. In 2005, Nisoli and collaborators [5] elegantly demonstrated that dietary restriction induced the activation of endothelial nitric oxide synthase (eNOS) and lead to enhanced mitochondrial biogenesis and increased oxygen consumption. Indeed, the effects of the diet were largely absent in eNOS deficient animals [5]. Further studies have found links between mitochondrial activity and CR. Fungal CR models present increments in respiratory activity [6]–[8], and CR in yeast can be promoted by NO•-stimulated mitochondrial biogenesis [9]. Furthermore, CR prevents the decline in respiratory activity seen in aging rats [10], [11] and increasing respiratory activity through the use of mitochondrial uncouplers enhances mouse lifespan [12]. Interestingly, both CR and uncouplers enhance mitochondrial biogenesis in insulin-sensitive tissues, in a manner involving protein kinase B (Akt) phosphorylation [13]."
Rapamycin, Resveratrol, Ginkgo Biloba all act on eNOS.
Edited by Skyguy2005, 30 October 2014 - 05:30 PM.
#4
Posted 05 December 2014 - 06:53 PM
I have been wondering about this paradox too... Leucine is the aa that is most potent in activating mTOR and activity in this pathway should decrease lifespan. Seems that the SRT induction one gets from Lecine can compensate sufficiently for the increased mTOR signaling. Still, it would be interesting to see the effects of a high leucine diet would be in combination with mTOR inhibition, e.g. rapamycin...
Or adding Reishi (cheaper alternative than Rapamycin). I'll let you know how it works out as I'm doing it now
Also tagged with one or more of these keywords: leucine, sirt1
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