2 replies to this topic

[NeuroGeneration]

I love Animal Pak, but I've come to learn that I have a homozygous mutation in my MTHFR c677t gene (up to 60% of people have a hetero or homozygous mutation in this gene), which leads to impaired methylation. 

 

Animal Pak contains inactive forms of B vitamins – namely, folic acid (400mcg) and B12 (cyanocobalamin, though it's also combined with the active methylcobalamin form).

 

Does anybody have any opinion on this and the level or risk? I love the convenience of the Animal Pak, but am concerned about the prospect for folic acid to build up as a toxin in my organs, and possibly lead to cancer. How real is this risk, versus hype? Should I avoid the Animal Pak all together? Any thoughts would be appreciated.

Edited by NeuroGeneration, 28 October 2014 - 09:26 PM.

[krillin]

200 mcg is the largest dose of synthetic folic acid that you can expect to fully metabolize, regardless of MTHFR polymorphism. (The relevant enzyme is DHFR.)

 

MTHFR 677 C->T can be treated with vitamin B2. They used 1.6 mg, but you can absorb about 25 mg if you want to experiment with higher doses.

[NeuroGeneration]

Yes, 23andMe.