39 replies to this topic

[eon]

if you're speaking of DMT, I'm curious if this drug below have any relation to it:

 

αMT (alpha-methyltryptamine), an anti-depressant from the tryptamine family; first developed in the Soviet Union and marketed under the brand name Indopan.

 

While I'm not sure if it's helpful for OCD, the profile is still interesting and I have no clue why it's a schedule 1 prescription drug.

 

"α-Methyltryptamine (abbreviated as αMT, AMT; former brand Indopan) is a psychedelic, stimulant, and entactogen drug of the tryptamine class.^[2][3] It was originally developed as an antidepressant by workers at Upjohn in the 1960s.^[4]"

 

"αMT is tryptamine with a methyl substituent at the alpha carbon. Its chemical relation to tryptamine is analogous to that of amphetamine to phenethylamine, amphetamine being α-methylphenethylamine. αMT is closely related to the neurotransmitter serotonin (5-hydroxytryptamine) which partially explains its mechanism of action."

 

Could this cause serotonin syndrome? Possibly? Its close relation to serotonin tells me that its psychedelic effect may be similar to psilocybin mushrooms.

 

"αMT acts as a relatively balanced reuptake inhibitor and releasing agent of the main three monoamines; serotonin, norepinephrine, and dopamine,^[5] and as a non-selective serotonin receptor agonist.^[6]"

 

http://en.wikipedia....ethyltryptamine

 

U noobs nothing helpful did ever come from this neurotransmitter pseudoscience esotericism talk. Better embrace some REAL shamanism with real hallucinogenic drugs or continue to go by your "mitochondrial support" (hahahhahaha) placebos for less risky stuff.

 

Edited by eon, 25 May 2015 - 04:07 AM.

[Metagene]

First thing I thought of http://en.wikipedia...._Mothers_Temple

 

 

"Some deaths have been associated with AMT especially in
combination with other substances and a number of countries have recently added AMT to
their controlled substances list. In summary, despite the general lack of preclinical or clinical
data on AMT, it appears that AMT produces effects and toxicities similar to other tryptamine
derivatives with hallucinogenic and stimulatory properties and therefore should be scheduled
as such."

 

"AMT may cause serotonin syndrome due to
its ability to inhibit MAO(8, 14)."

 

Alpha‐methyltryptamine (AMT) Critical Review Report

 

https://drive.google...iew?usp=sharing

Edited by Metagene, 25 May 2015 - 10:42 PM.

[eon]

This article on pubmed may be old (1992):

 

The serotonin hypothesis of obsessive compulsive disorder: implications of pharmacologic challenge studies.

 

http://www.ncbi.nlm..../pubmed/1532961

 

It may still be valid and may be partly what the culprit is when it comes to my OCD considering I seem to be sensitive to serotonergics (I don't like them, I had serotonin syndrome before), even with just the saffron tea seem to have triggered feeling like I'm out of it (psychotic, etc.). I'm not sure if lysine may be of help for OCD (aside from the known Inositol) as well looking at this quote from the article and since lysine regulates 5ht:

 

"While the nature of the dysregulation in serotonin transmission that may attend obsessive compulsive disorder has yet to be fully elucidated, evidence accumulates that 5-HT function in part modulates obsessive compulsive symptoms."

 

I wonder if there are different forms or modifications of lysine that are not yet studied but MAY hold more hidden potential?

 

"Lysine has a anxiolytic action through its effects on serotonin receptors in the intestinal tract, and is also hypothesized to reduce anxiety through serotonin regulation in the amygdala.^["

 

^{http://en.wikipedia.org/wiki/Lysine}

Edited by eon, 02 June 2015 - 10:27 AM.

[AOLministrator]

Yeah keep spamming serotonin into your neurons that will surely modulate some obsessive compulsive symptoms.

[Ark]

I've heard that neurological enzymes play a big role in OCD.

[eon]

Really, explain?

 

I've heard that neurological enzymes play a big role in OCD.

 

[Ark]

Really, explain?

I've heard that neurological enzymes play a big role in OCD.

For one DAO enzyme as it plays a roll in breaking down neurotransmitters and if it's off it can contribute to OCD, if memory serves me.

[eon]

"Diamine oxidase (DAO) is an essential enzyme in the body that breaks down histamine."

 

Does this mean too much histamine is not needed and would an antihistamine be what's needed? Although I do not want to take this route though.

 

I've just looked into enzyme therapy and it seems like an interesting new way of treating certain conditions. It's still too new for me to know much about it so I'll look around for more info. Hopefully someone here who knows more about enzyme therapy can chime in.

Edited by eon, 03 June 2015 - 10:05 AM.

[Ark]

"Diamine oxidase (DAO) is an essential enzyme in the body that breaks down histamine."

Does this mean too much histamine is not needed and would an antihistamine be what's needed? Although I do not want to take this route though.

I've just looked into enzyme therapy and it seems like an interesting new way of treating certain conditions. It's still too new for me to know much about it so I'll look around for more info. Hopefully someone here who knows more about enzyme therapy can chime in.

http://www.deficitda...y/#.VW7YFsvn8lM

[eon]

I've tried some enzymes before since I got some samples of them from pureformulas but I never looked into what an enzyme is THEN. They are generally marketed as for digestion. Never thought of a connection with neurological disorders that can benefit from taking enzymes. But I read that the gut is the 2nd brain. What are some good enzymes? I know they all have varied purpose and actions. One that comes to mind is papain from papaya. I think I felt wonderful the first time I tried a sample of an enzyme but it was just a 1 or 2 pill sample to get the full benefits but actually felt great considering an enzyme is said to work in an accelerated manner. I think some of these enzymes have a name that ends in "ase" like amylase, etc.

 

 

Edited by eon, 03 June 2015 - 11:31 AM.