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Why is it that ANYTHING that is helpful for ADHD seems to have some negative effect on Testosterone?

adhd stimulants methylphenidate amphetamine testosterone

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15 replies to this topic

#1 agwoodliffe

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Posted 03 November 2014 - 06:41 PM


I'm no pharmacologist, so forgive me if this is a rather naive post.

 

But I have read studies which document that both Methylphenidate and Amphetamine have some form of testosterone-blunting effect. With Methylphenidate, this appears to be due to increased liver metabolism, whereas with Amphetamine, there appear to be multiple routes.

Funnily enough, even herbal dopamine raisers, like Scutellaria Baicalensis and Salvia Miltiorrhiza, have a suppressant effect.

I am of the opinion that all of these are due to a vasoconstrictive effect of dopamine/norepinephrine (at least to some degree).

 

Since the standard stimulants are regarded to have the most efficacy, I have to ask, is this effect prominent at standard therapeutic doses?

 

If so, could these effects be mitigated with well known testosterone-sparers, like D-Aspartic Acid and Eurycoma Longifolia?


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#2 zompy

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Posted 03 November 2014 - 11:23 PM

Just read another article on D-aspartic claiming it does not even influence Testosterone. It'd rather try something else.



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#3 agwoodliffe

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Posted 03 November 2014 - 11:42 PM

Like steroids? ;)



#4 OneScrewLoose

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Posted 05 November 2014 - 08:41 AM

Can you link to studies that demonstrate that stimulants like the ones mentioned above "blunt" testosterone?


Edited by OneScrewLoose, 05 November 2014 - 08:42 AM.

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#5 RonBurgandy

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Posted 10 November 2014 - 03:57 AM

Mucana pruriens, Ashwaganda and CDP Choline.


Edited by RonBurgandy, 10 November 2014 - 03:58 AM.


#6 d3C3pT0R

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Posted 28 November 2014 - 02:59 PM

Link some studies



#7 ToJump

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Posted 28 November 2014 - 08:29 PM

OP, to answer your question in a common sense, "simple" manner:

-In general, pharmaceutical drugs are more potent than herbs;
-Pharmaceutical drugs often come with shitty side effects;

That's it. You can try herbal supplements that won't blunt testosterone, but they will likely be milder than amphetamines...

#8 Dan1976

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Posted 28 November 2014 - 10:50 PM

High testosterone makes you chase skirts. By inhibiting testosterone you avoid this distraction and you can focus better. :-)

#9 TheFountain

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Posted 29 November 2014 - 01:12 AM

Cause, sex man sex. Havin a dick is distracting. Hence the ADHD. 



#10 Noopho

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Posted 01 December 2014 - 09:53 PM

ZMA supplements help quite a bit when trying to level out hormonal disturbance



#11 solarfingers

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Posted 03 December 2014 - 05:13 AM

I found that Adrafinil + Caffein is the magic bullet for my ADHD... I don't need to take it every day and can get by on taking it just once a week as it's effects tend to linger with me.



#12 david ellis

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Posted 05 December 2014 - 09:57 PM

No troubles with testosterone, I use lithium aspartate (5mg) to blunt the methylphenidate. YMMV

#13 OneScrewLoose

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Posted 06 December 2014 - 01:41 PM

I found that Adrafinil + Caffein is the magic bullet for my ADHD... I don't need to take it every day and can get by on taking it just once a week as it's effects tend to linger with me.

 

I know Adrafinil is easier to get, but it's not good for the liver. Try to get a script for modafinil or armodafinil if you can.



#14 solarfingers

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Posted 07 December 2014 - 12:20 AM

I know Adrafinil is easier to get, but it's not good for the liver. Try to get a script for modafinil or armodafinil if you can.

 

 

I think it's OK in moderation.  I had my blood tested... no problem.



#15 OneScrewLoose

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Posted 07 December 2014 - 01:22 AM

Do you not qualify under the patient assistance program for either?



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#16 solarfingers

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Posted 07 December 2014 - 06:16 AM

No  my insurance turned down the doctors prescription for Modifinil or Armodafinil...  I had a script but could not fill it without paying an exorbitant fee.

 







Also tagged with one or more of these keywords: adhd, stimulants, methylphenidate, amphetamine, testosterone

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