11 replies to this topic

[The Ripper]

Article: http://www.scienceda...40110103526.htm

It can be bought already: http://www.fisher.co...-m-p-300-c.html

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c60 has only had toxicity studies done on rats and plenty of people including myself are already taking it without waiting for definitive human trials. Likewise, Tiron appears to be extremely effective. How come more on here haven't tried to calculate a safe dose based on interspecies scaling and start taking it?

 

[Heyman]

Good question. I wonder how one would even get it into the skin as lots of substances its very hard to get them into the skin. There are also safety issues, who says reducing radicals by 100% is a good thing? Your cells try to communicate and actually do useful things with these radicals. But this also applies to c60. However I don't understand people who use c60 either, at least not if they are not threatened by death immdiately. There is no way I would use that right now instead of waiting several years into the future when it is more researched.

[PWAIN]

Looks interesting. C60 in oo was considered reasonably safe because testing had been done in humans with C60. It was also supposedly responsible for a considerable amount of life extension in mice. This seems to be limited to skin and is of unknown safety in humans. Antioxidants don't appear to be the answer to life extension and it is not clear whether this targets mitochondria. On the plus side, it appears to be super cheap...

[Logic]

It seems that iron is freed from iron-sulphur enzymes within the cell by UVA.
The free iron reacts with ROS causing irreversible oxidative damage.
Tiron is able to chelate the iron inside the mitochondria.
http://www.longecity...w-anti-oxidant/

More local links:
http://www.longecity...about-it/page-3

[The Ripper]

It seems that iron is freed from iron-sulphur enzymes within the cell by UVA.
The free iron reacts with ROS causing irreversible oxidative damage.
Tiron is able to chelate the iron inside the mitochondria.
http://www.longecity...w-anti-oxidant/

More local links:
http://www.longecity...about-it/page-3

Crazy stuff!

Are there any human trials going on right now? And is there any reason we don't just scale the doses used in mice for humans and try it ourselves right now?

Finally, these results are from ingestion of Tiron, not topical application, correct?

[Logic]

Crazy stuff!

Are there any human trials going on right now? And is there any reason we don't just scale the doses used in mice for humans and try it ourselves right now?

Finally, these results are from ingestion of Tiron, not topical application, correct?

I asked myself the same question when I read about this stuff.
I haven't looked deeply but it looks like the studies are all in vitro atm?
Worth keeping an eye on though.

[SuicidalTraveler]

Yep.

People should give this more attention.

[Logic]

Yep.

People should give this more attention.

 

Yep!  

 

http://www.longecity...idant/?p=763513

[DanielEdward]

It seems that iron is freed from iron-sulphur enzymes within the cell by UVA.
The free iron reacts with ROS causing irreversible oxidative damage.
Tiron is able to chelate the iron inside the mitochondria.
http://www.longecity...w-anti-oxidant/

More local links:
http://www.longecity...about-it/page-3

So if we are not taking Tiron should we decrease dietary iron? I thought increased iron levels correlated with less oxidative damage/ skin damage

[niner]

So if we are not taking Tiron should we decrease dietary iron? I thought increased iron levels correlated with less oxidative damage/ skin damage

 

If anything, it's the other way around.  Higher iron means more oxidative damage.  More than one person here uses blood donation as a way of keeping their ferritin level below 100.

[DanielEdward]

So if we are not taking Tiron should we decrease dietary iron? I thought increased iron levels correlated with less oxidative damage/ skin damage

If anything, it's the other way around. Higher iron means more oxidative damage. More than one person here uses blood donation as a way of keeping their ferritin level below 100.

I've been increasing iron thinking I was doing good (I'm slightly anaemic looking). This makes me wonder where else I may be unknowingly going wrong with my diet plan. I'm considering stopping trying to perfect my diet and just following my gut instinct on food

[Logic]

 

 

So if we are not taking Tiron should we decrease dietary iron? I thought increased iron levels correlated with less oxidative damage/ skin damage

If anything, it's the other way around. Higher iron means more oxidative damage. More than one person here uses blood donation as a way of keeping their ferritin level below 100.

I've been increasing iron thinking I was doing good (I'm slightly anaemic looking). This makes me wonder where else I may be unknowingly going wrong with my diet plan. I'm considering stopping trying to perfect my diet and just following my gut instinct on food

 

 

IIRC a shortage of one of the B vitamins, or its not being metabolised properly is responsible for anemia when iron is plentiful.
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