Disclammer: Its a pain to provide references for long texts, so either:
dont believe it( no offence, its actually good to be sceptic), do a recherche on Your own and/or ask me for interresting/certain ones.
First, You can try to ask for Mirtazapine,
Mianserine -->which is problematic because of agranulocytosis(blood tests are needed every few weeks) but it affects way more 5-ht receptors which are implicated in 5-ht release from the Raphe Nucleus like : 5-ht2b and 5-ht6
5-ht2b seems,nevertheless, to be actually good because it releases dopamine(in the VTA) and serotonine .
The anxiogenic receptors could be 5-ht2c and 5-ht1a (postsynaptic) but 5-ht1a decreases also vasoconstriction and releases Dopamine in the PFC, so I would rather avoid to touch it.
As said 5-ht6 could be interresting but the test results in rats are incoclusive in terms of anxiety.
(afaik)Same thing for 5-ht7
A suggestion; I have some enduring problems due to cannabis abuse in the adolescence.
When I began investigating, I had actually the problem that there werent many studies about the consequences and mechanisms, so I looked for a similair disease that is more researched: Negative symptoms in schizophrenia.
Its not the same because THC is able to reverse NMDA inhibition induced cognitive and affective deficits but there were nevetheless some valuable informations.
Ergo: I´ve found recently this correlation: autism hyperserotonemia
Google it but rather only for the cases where too much serotonine is the cause or the topic of the study.
You might also find other diseases where too much 5-htp is the cause and look what helped.
Now You can find what they tried e.g.:
CURRENT AND EMERGING THERAPEUTICS OF AUTISTIC DISORDER AND RELATED PERVASIVE DEVELOPMENTAL DISORDERS
http://www.google.de...5533,bs.1,d.ZWU
As said in a prevorious post, You could look for PSSD (post SSRI sexual disorder) treatments:
Serotonin 5-HT(1)A Receptor and Male Sexual Function / Motivation
http://www.longecity...tivation/page-2
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In regards of Your issues:
The funny thing about the brain is, that no one can say anyting definitive on the first look.
From my laymans opinion, only something like a PET, special(?) MRI or perhaps epigenetic markers could say something to 100 % about You disease/issue.
This is how I think about this:
--> It could be freely just a deregulation (increase/decrease) of:
Serotonine
and/or serotonine receptors
and/or other receptors
and/or a damage.
and perhaps something epigenetic ( but I personally doubt this one)
So You have to see whether there is something to narrow it down or reveal like:
too much serotonine (i.e. SSRI side-effects) causes insomnia, mania and so on.
Just an laymans Idea:
By taking passionflower You would indeed increase serotonine but also dopamine and (nor)adrenaline.
On the ther hand, 50 mg 5-htp on it self, like endogneous serotonine, can increase and decrease dopamine, noradrenaline and glutamate.
But this would, more or less definitive, point out the issue, if Youre still unsure about having too much serotonine.
NOTE: 5-htp is a direct precursor of Serotonine !
there is no break, so Your body convert it as 1:1
and You would die or end up in a serotonine syndrome if You´re taking too much !!!
50mg are for me personally tolerable, I dont give any guarantees that its safe for You
Speak with Your Doctor first about this or any idea.
Edited by Flex, 24 April 2015 - 06:43 PM.