My wheels were turning last night and I started to think about the possibility of the possibility/benefit of lipospheric c60oo and if it had already been conceived. It appears so, as I came across this paper:
Liposome Formulation of Fullerene-Based Molecular Diagnostic and Therapeutic Agents
Not only does it seem that this method would increase the effectiveness of the c60oo itself, but other compounds could also be encapsulated within the bucky cage, then within a liposome. And given that liposomes are easy to make, especially if one has a good commercial untrasonic bath, my wheels began turning even faster.
This opens up an exciting area of discussion..
So let me propose a few questions:
1. If one had the raw fullerenes, would the method of encapsulating them in liposomes be the same as say, vitamin C?
2. If so, how difficult a process would it be to then (or prior rather, or simultaneously) encapsulate another compound within the fullerene?
3. I was thinking something like S-Acetyl-Glutathione, which seems is already sufficiently available might be a good candidate to increase its penetration into cells even further, given Glutathione's notorious problem in first surviving the digestive tract and then subsequent problem of penetrating the cell.
4. Which brought me to my next question about what can be encapsulated in a liposome anyway. Obviously a peptide or something delicate could not, at least through an ultrasonic method due to its likely destruction from the vibrations and heat (but could possibly be made to a lesser extent just with alcohol method only) but could these bonded aminos such as SAG or NAC be encapsulated? How about something like ubiquinol? I've seen vitamins such as D sold as lipospheric but don't know the efficacy of doing so. Thoughts?
5. C60oo seems like an excellent candidate in that, rather than being emulsified in oo, which clearly works great, fullerene's ease of combining with one lipid should be easily translated over to another lipid such as lecithin (or even specifically phosphatidylcholine only). But in examining the Baati method of making the c60oo, it was created with a magnetic stirring and over long periods of time, filtered, etc. How or in which step of the process could one apply these principles to a liposomic formulation, or would one even want/need to?
6. On the topic of c60oo in general (not relative to the above about liposomes but rather just a general c60oo question), would it be beneficial relative to the fullerenes to combine them with a different lipid such as a macadamia oil or a saturated fat instead, notwithstanding the health benefits/negatives of that particular lipid?
