J Phys Chem B. 2014 Mar 6;118(9):2316-30.
Glutamine can destroy neuron mitochondria
#1
Posted 15 November 2014 - 05:14 PM
#2
Posted 15 November 2014 - 08:27 PM
Interesting, Colgan reccomended using Alpka-Ketoglutarate to avoid the ammonia issue.
#3
Posted 17 November 2014 - 09:42 PM
-"reacts with water and yields glutamate and excess ammonia "
Interesting, Colgan reccomended using Alpka-Ketoglutarate to avoid the ammonia issue.
I'd like to know more about this. I like many of Glutamine's actions but had heard something about the Trojan horse stuff and subsequently put it on hold. Are we confident in GAKG or does it have perils of its own?
Edited by ikon2, 17 November 2014 - 09:43 PM.
#4
Posted 19 November 2014 - 05:38 AM
wow! thanks for the post...
#5
Posted 19 November 2014 - 12:14 PM
glutamine is HIGHLY HIGHLY regulated in the CNS. you will never have excess or too little. here is a study of intravenous glutamine in brain injury.
Prolonged continuous intravenous infusion of the dipeptide L-alanine- L-glutamine significantly increases plasma glutamine and alanine without elevating brain glutamate in patients with severe traumatic brain injury.
Of note:
High dose L-alanine-L-glutamine infusion (0.75 g/ kg/ d up to 5 days) increased plasma and brain glutamine and alanine levels. This was not associated with elevated glutamate or signs of potential glutamate-mediated cerebral injury. The increased nitrogen load should be considered in patients with renal and hepatic dysfunction
#6 Guest_Funiture2_*
Posted 01 October 2015 - 10:38 PM
When I take anywhere from 2-5 grams of L-Glutamine on an empty stomach I get tired, less motivated to exercise, a bit brain-fogged and very irritable for no good reason. Also, my eyelids feel heavier and one of them will twitch just enough to be bothersome but not enough to be easily seen by other people. Sounds nuts, but I can count on this happening every single time
Other experiences that confirm my own:
http://forum.bulletp...iment-thoughts/
"I did 10g of L-Glutamine powder form in the morning for 3 days and then today i did 3x10g. I got REALLY tired, irritable, sluggish and annoyed at everyone. I basically wanted to kill my girlfriend for asking me what i'd like to eat (nice, huh?).
I've been reading a bit on glutamine since then ofcourse and found that MSG sensitive people should not consume it. Well, I am very MSG sensitive. So it might be that, anyone know anything about this?"
http://www.curezone....m.asp?i=2015165
"I'm convinced I need to be taking l-glutamine to help fix a leaky gut / help lyme symptoms but it seems I cannot tolerate it at all. Even just 500mg a couple times a day makes me so irritable I'm actually scared for myself and everyone around me. It turns me into an angry, psychotic, mess."
Also tagged with one or more of these keywords: glutamine, mitochondria, neurons
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