It's pretty well established that Choline and related drugs (Huperzine A, Citicoline) have devastating effects for people prone to depressive disorder.
This seems to be due to a positive link between the chemical Acetylcholine and Cortisol.
What really is confusing me is that there are several plants that have also been cited as increasing Acetylcholine, including: Ashwagandha, Lemon Balm, Ginkgo and Holy Basil, but they have actually been found to REDUCE cortisol levels.
So I wonder, for those who have experience, do these herbs tend to worsen depression or help with it?