11 replies to this topic

[mealz13]

I was wondering if anyone could summarize, in list form, mTOR inhibitors; ie how many there are, whether supplements or prescriptions, and what they are. I have been having trouble finding a concise list so it would be much appreciated, as I try to decide which one (s) to take.

[to age or not to age]

Here are a few:

Rapamycin

Resveratrol

Curcumin

 

With respect to  the mtor gene, and I was told this on video by Dr Brian Kennedy, you want to down regulate its

activity, but not entirely.  Completely cutting mtor activity causes neurological damage.

So, in the case of rapamycin - which profoundly down regulates mtor - it would need to be cycled in some

manner.

Rapamycin seems to be available for scientific study on the internet. Kennedy was one of the original 

proponents of mtor, and has recently done experiments on dogs at the the Buck Institute. He also oversees

three labs in China also doing this research.

I will post a video segment on Kennedy and mtor soon.

[RJ100]

Are there studies showing resveratrol inhibiting mTOR in humans? I believe all the research is in vitro.

[krillin]

ReishiMax at 28 mg/kg in mice ~ 160 mg/day in humans.

For resveratrol, 5 microM is the lowest I've seen. They didn't actually mention mTOR in that paper, however, so the lowest concentration that definitely affects mTOR is 25 microM. Either way, those concentrations would require taking multiple pills.

For curcumin, 2.5 microM is the lowest I've seen, which is unachievable. 4 grams of Longvida gets you just 0.22 microM.

[krillin]

I think the 0.22 microM from 4 g Longvida is actually a mistake made by Trutt that I have been perpetuating. He says he got that number from this paper in which 4 g actually only gives you 0.11 microM. (The Longvida was given with just water, so I don't know how the CurcuWin partisans can run around saying that the Longvida's Cmax was inflated by using cream cheese bagels.)

[mealz13]

Thank you very much, Krillin and TAONTA.  I will look into all of those items

Edited by mealz13, 26 November 2014 - 06:17 PM.

[Flex]

Saikosaponin-d from Bupleurum chinense (also called chai hu) and Bupleurum falcatum affects mTor

 

Saikosaponin-d, a novel SERCA inhibitor, induces autophagic cell death in apoptosis-defective cells

http://www.ncbi.nlm....les/PMC3730398/

 

Autophagic effects of Chaihu (dried roots of Bupleurum Chinense DC or Bupleurum scorzoneraefolium WILD)

http://www.ncbi.nlm....les/PMC4165614/

 

[Flex]

Sry I´m probably mistaken. It seems to me that Saikosaponins do activate mTor and that THC inhibits mTor.

 

Tetrahydrocannabinol, the active component of marijuana, induces ER stress and subsequent Akt/mTOR inhibition leading to autophagy in glioma cells.

Saikosaponin-d, a novel SERCA inhibitor, induces autophagic cell death in apoptosis-defective cells

http://www.ncbi.nlm....les/PMC3730398/

 

Btw: mTor activation decreases memory functioning

 

In addition, non-amnesic doses of either the mTOR blocker rapamycin or the protein synthesis inhibitor anisomycin abrogated the amnesic-like effects of THC

http://www.nature.co...bs/nn.2369.html

Edited by Flex, 07 March 2015 - 11:08 PM.

[Kalliste]

One of the safest and surest ways to inhibit mTOR seems to be fasting. Valter Longo has published some very interesting papers on this. It seems a 3-4 day faste is enough for longterm metabolic change to occur.

http://joshmitteldor...-fast-day-four/

[Nate-2004]

I stumbled across this helpful article here while looking around examine.com and googling:

 

https://selfhacked.c...tor-inhibitors/

 

From the article I gathered that mTOR is a double edged sword. You need it for physical performance and growth but it causes aging and all its subsidiary diseases. 

 

One thing of note is that Olive Oil is supposedly an mTOR inhibitor which would explain my experience with C60 EVOO and workouts.

 

On this page there is a long list of inhibitors which I tried to paste below but got an error saying "You are not allowed to use that image extension on this community"... strange since there was no image, just text. Anyway, click the link, It's cool that I'm taking a number of these things.

 

It says that leucine, a collagen peptide and amino acid is an mTOR activator which sucks because it's in the collagen peptides I take at night. Perhaps mTOR is necessary for collagen production as well? I'll have to Google that one.

 

Further research on leucine I discovered it's a SIRT1 activator but so far only in vitro studies have indicated this.

Edited by Nate-2004, 04 September 2016 - 03:05 PM.

[hamishm00]

I stumbled across this helpful article here while looking around examine.com and googling:

 

https://selfhacked.c...tor-inhibitors/

 

From the article I gathered that mTOR is a double edged sword. You need it for physical performance and growth but it causes aging and all its subsidiary diseases. 

 

One thing of note is that Olive Oil is supposedly an mTOR inhibitor which would explain my experience with C60 EVOO and workouts.

 

On this page there is a long list of inhibitors which I tried to paste below but got an error saying "You are not allowed to use that image extension on this community"... strange since there was no image, just text. Anyway, click the link, It's cool that I'm taking a number of these things.

 

It says that leucine, a collagen peptide and amino acid is an mTOR activator which sucks because it's in the collagen peptides I take at night. Perhaps mTOR is necessary for collagen production as well? I'll have to Google that one.

 

Further research on leucine I discovered it's a SIRT1 activator but so far only in vitro studies have indicated this.

 

Have a look at the leucine metabolite HMB - it seems even more effective than leucine when it comes to collagen production but via a different mechanism to Leu. While HMB and Leu both increase anabolic signalling (mTOR), Leu is much more pronounced (i.e. p70S6K1 signalling 90 min vs. 30 min for HMB). HMB might be a better way to go than leucine in every respect. There is also an age associated decline in the conversion of leucine to its metabolite HMB which is interesting.
 

[Nate-2004]

Thanks, I looked at this page but doesn't mention anything about collagen. Examine.com is my new supplement wiki at the moment. It's pretty comprehensive so far though it's missing a few things. The page on HMB does have a lot of info though.