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Cyanocobalamin vs Methylcobalamin vs Hydroxocobalamin

vitamin b12 cyanocobalamin methylcobalamin hydroxocobalamin

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#1 jroseland

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Posted 25 November 2014 - 06:05 PM


I need to create a concise presentation comparing the forms of Vitamin B12, this is is what I came up with. Is this an accurate synopsis? Anything major I'm missing?

 

If you are Vitamin B12 deficient, either form will benefit you, however certain forms are more bioavailable than others. Certain molecule shapes are more likely to cross the blood brain barrier or benefit the central nervous system.

Cyanocobalamin is the base model, the benefits it offers are dubious.

Methylcobalamin is significantly more bioavaliable, however the body is a master regulator and if you have sufficient Vitamin B12 levels already it gets flushed,

Hydroxocobalamin is the holy grail of Cobalamin’s and the most expensive, but also the most bioavailable. It releases at a slower pace which actually increases the baseline of the vitamin in the body.

To quote a Dutch human study “...application of hydroxocobalamin in cobalamin-deficient patients results in fast nasal absorption and leads to sustained increase of baseline cobalamin concentrations.”

So for Biohacker’s who already have a highly calibrated diet and want to supplement energy levels and spark neurogenesis for high leverage skill acquisition, Hydroxocobalamin is the clear choice.

Vitamin B12 is a great case study of the general uselessness of of multivitamins, it’s a well known enough vitamin that most laypeople have heard of it and know it’s important to general health. However, the vast majority of multivitamins that include it use the cosmetic grade or less bioavailable, cheaper forms of Vitamin B12. If you’ve ever noticed, while taking a multivitamin, that your pee is really colorful, that’s because the bioavailability of the individual components of the multivitamin are just being flushed out of your system.


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#2 Malf

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Posted 04 June 2020 - 04:30 PM

I was thinking of trying AOR Hydroxocobalamin b12, I heard if you take this version you dont have to take it daily and can take it every other day is this true?



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#3 Zaul

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Posted 17 June 2020 - 01:06 PM

Increase in Circulating Holotranscobalamin After Oral Administration of Cyanocobalamin or Hydroxocobalamin in Healthy Adults With Low and Normal Cobalamin Status

 

 

Conclusions: Administration of cyanocobalamin resulted in a more than twofold increase in holoTC in comparison with hydroxocobalamin. The absorptive capacity was reached only by doses above 3 µg cobalamin. Our results underscore the importance of using the same form of cobalamin when comparing uptake under different conditions.

 

Cobalamin Coenzyme Forms Are Not Likely to Be Superior to Cyano- And Hydroxyl-Cobalamin in Prevention or Treatment of Cobalamin Deficiency

 

 

Methylcobalamin (MeCbl) and adenosylcobalamin (AdoCbl) are coenzymes for methionine synthase and methylmalonyl-CoA mutase, respectively. Hydroxylcobalamin (HOCbl) and cyanocobalamin (CNCbl) are frequently used for supplementation. MeCbl and AdoCbl have recently emerged as alternative forms in supplements. In the light of metabolic transformation of Cbl into its cofactor forms, this review discusses current evidence on efficacy and utility of different Cbl forms in preventing or treating Cbl deficiency. Cbl-transporting proteins bind and mediate the uptake of all aforementioned forms of Cbl. After internalization and lysosomal release, Cbl binds to the cytosolic chaperon MMACHC that is responsible for (i) flavin-dependent decyanation of [CN-Co(3+) Cbl to [Co(2+)]Cbl; (ii) glutathione-dependent dealkylation of MeCbl and AdoCbl to [Co(2+/1+)]Cbl; and (iii) glutathione-dependent decyanation of CNCbl or reduction of HOCbl under anaerobic conditions. MMACHC shows a broad specificity for Cbl forms and supplies the Cbl(2+) intermediate for synthesis of MeCbl and AdoCbl. Cobalamin chemistry, physiology, and biochemistry suggest that MeCbl and AdoCbl follow the same route of intracellular processing as CNCbl does. We conclude that supplementing MeCbl or AdoCbl is unlikely to be advantageous compared to CNCbl. On the other hand, there are obvious advantages of high parenteral doses (1-2 mg) of HOCbl in treating inborn errors of Cbl metabolism.

 

Effect of two different sublingual dosages of vitamin B12 on cobalamin nutritional status in vegans and vegetarians with a marginal Q9 deficiency: A randomized controlled trial

 

 

 

Conclusions: In our experimental conditions, both (Cyanocobalamin) supplements were able to restore adequate serum concentrations of vitamin B12 and to improve the levels of related metabolic blood markers in subjects with a marginal deficiency. The results support the use of a sublingual dosage of 50 μg/day (350 μg/week) of cobalamin, instead of 2000 μg/week (provided as a single dose), to reach a state of nutritional adequacy of vitamin B12 in this target population.

 


Edited by Nigeria Custom Officer, 17 June 2020 - 01:12 PM.






Also tagged with one or more of these keywords: vitamin b12, cyanocobalamin, methylcobalamin, hydroxocobalamin

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