Looks if this one has flown under the radar. Another potential Alzheimer's disease treatment but notable for being a Sigma-1 agonist.
ANAVEX 2-73, an orally available drug candidate, is under investigation to treat Alzheimer’s disease. In previous preclinical studies, ANAVEX 2-73 was shown to prevent, halt, and/or reverse Alzheimer’s disease progression by targeting sigma-1 and muscarinic receptors and reducing oxidative stress in neurons, which is believed to lead to their damage and ultimately death.
The Phase 2a trial will enroll 32 mild to moderate Alzheimer’s disease patients and aims to evaluate bioavailability, dose finding and response, cognitive efficacy, and whether ANAVEX 2-73 added to donepezil — known as “ANAVEX PLUS” — is a potentially effective add-on therapy. Donepezil, an acetylcholinesterase inhibitor, is the current standard therapeutic for Alzheimer’s disease patients. Specifically, data from a previous Phase 1 human clinical trial showed ANAVEX 2-73 was efficient in preventing amnesia events and had neuroprotective properties when administered to Alzheimer’s disease patients. ANAVEX PLUS was also shown to have a high synergistic effect being able to revert memory loss in Alzheimer’s disease patients, with approximately 80% higher efficiency comparing to other drugs.
http://alzheimersnew...phase-2-trials/
