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Something new: mollugin has a dozen awesome benefits

mollugin neuroprotective cfos anti-inflammatory cox antitumor antiviral brain health

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#1 StevesPetRat

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Posted 01 December 2014 - 10:50 PM


This stuff sounds incredible. I stumbled across it on my quest for cFos inhibitors (which it also is).
http://www.ncbi.nlm....ubmed/21236252/

Mollugin, a bioactive phytochemical isolated from Rubia cordifolia L. (Rubiaceae), exhibits antimutagenic activity, antitumor activity, antiviral activity, and inhibitory activity in arachidonic acid- and collagen-induced platelet aggregation. In this study, we investigated the effects of mollugin as a neuroprotective agent in glutamate-induced neurotoxicity in the mouse hippocampal HT22 cell line and as an anti-inflammatory agent in lipopolysaccharide-induced microglial activation in BV2 cells. Mollugin showed potent neuroprotective effects against glutamate-induced neurotoxicity and reactive oxygen species generation in mouse hippocampal HT22 cells. In addition, the anti-inflammatory effects of mollugin were demonstrated by the suppression of pro-inflammatory mediators, including pro-inflammatory enzymes (inducible nitric oxide synthase and cyclooxygenase-2) and cytokines (tumor necrosis factor-α and interleukin-6). Furthermore, we found that the neuroprotective and anti-inflammatory effects of mollugin were linked to the up-regulation of the expression of heme oxygenase (HO)-1 and the activity of HO in HT22 and BV2 cells. In addition, the effects of mollugin resulted in the nuclear accumulation of nuclear factor-E2-related factor 2 (Nrf2) in HT22 and BV2 cells. Furthermore, mollugin also activated the p38 mitogen-activated protein kinase (MAPK) pathway both in HT22 and BV2 cells. These results suggest that mollugin may be a promising candidate for the treatment of neurodegenerative diseases related to neuroinflammation.

Now, the only question is, where can we get the pure extract? I've ordered some rubia cordifolia powder and will update later.

#2 chemicalambrosia

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Posted 02 December 2014 - 03:26 AM

Interesting. It has traditional uses, but they are pretty varied. Maybe I'll buy some and try it out after drinking, give it a good real world test.



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Also tagged with one or more of these keywords: mollugin, neuroprotective, cfos, anti-inflammatory, cox, antitumor, antiviral, brain health

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