Hey all,
Couldn't find any decent publications on this, so I thought I would ask.
My dad has stage 4 lung cancer. Responded very well to alimta/avastin and is on maintenance. Primary tumor in lung and metastasis in hip shrunk considerably. He had a slightly enlarged neck lymph node from the beginning (2 years ago). About 8 months ago, he got a Vitamin D test, and was found to deficient (if I recall correctly, around 17 ng/mL). He was told to supplement with 5000 IU every day. This was 8 months ago.
A few months ago, he did a maintenance scan, and primary tumor and hip metastasis was found to have shrunk even more considerably. However, the lymph node in his neck was seen as having enlarged slightly. Is it possible that this is pseudo-progression due to increased immune response? He just had a biopsy done this week and I won't find out results of tumor presence or mutation profiling for about two weeks. Any differential diagnosis suggestions? The enlarged lymph node is in the left anterior cervical lymph chain, if that helps.
Any suggestions? Supplement ideas? Could it be pseudo-progression or immune related inflammation?
Thank you for all your help
