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"So Does Ibuprofen"


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#1 reason

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Posted 18 December 2014 - 10:15 PM


Every few years a new hot thing emerges in the field of drug candidates to slow aging. It was sirtuins for a while and then rapamycin and there will be others in due course. This happens because it is very possible to raise funding, start a company, and make a lot of money from this sort of thing even if - as is always the case to date - nothing of significance ever comes of it in terms of treatments that can actually extend life. As I've said in the past, this all seems like a really great cover story for the real scientific goal of amassing detailed data on the operation of cellular metabolism. The stated goals of slowing aging serve to draw in investment that would otherwise be hard to find at the needed levels: metabolism is ferociously complex, and trying to map it is chewing up billions of dollars. This is work that should be done, and the faster the better, but I think it disingenuous to talk of any real possibility that significant human life extension can result from it in the next few decades.

For real progress in treating aging an entirely different direction in scientific strategy is needed. Not mining the natural world for drug candidates that might slow down aging in poorly understood ways by altering poorly understood metabolic mechanisms, but rather deliberately aimed efforts to repair the known and comparatively well understood forms of damage that cause aging. We can bypass the need for a full and detailed understanding of how this damage interacts with every part of our metabolism to cause aging by taking the well validated and time-proven list of fundamental differences between old tissue and young tissue - a list of forms of cellular and molecular damage - and then repairing those differences. There is even a detailed set of research plans leading to treatments that can achieve this goal, which is a very large departure from the world of slowing aging through metabolic manipulation, where there is no plan to speak of and nowhere near enough knowledge to create one.

This is not even to mention the fact that slowing down damage accumulation can never be as good as repairing damage in terms of benefits delivered, and slowing further damage can do very little for old people who are already very damaged. The old need repair, and repair as a strategy is simply better overall in any case. It continues to amaze me that the clearly far worse, far more expensive, far less understood approach to treating aging is the one that dominates in this small research community.

In any case, every time a new overhyped drug candidate to slow aging emerges people get excited about it. Short memories, if you ask me. But the next time that someone you know in the community becomes fired up about early stage development of an age-slowing drug candidate that extends life in animal studies you can offer some needed perspective by saying "but so does ibuprofen." And what does ibuprofen do for life span in humans? Nothing meaningful enough to show up in five decades of trials, studies, and worldwide usage.

Ibuprofen Use Leads to Extended Lifespan in Several Species, Study Shows

"We first used baker's yeast, which is an established aging model, and noticed that the yeast treated with ibuprofen lived longer. Then we tried the same process with worms and flies and saw the same extended lifespan. Plus, these organisms not only lived longer, but also appeared healthy." The treatment, given at doses comparable to the recommended human dose, added about 15 percent more to the species lives. In humans, that would be equivalent to another dozen or so years of healthy living.

The three-year project showed that ibuprofen interferes with the ability of yeast cells to pick up tryptophan, an amino acid found in every cell of every organism. Tryptophan is essential for humans, who get it from protein sources in the diet. "We are not sure why this works, but it's worth exploring further. This study was a proof of principle to show that common, relatively safe drugs in humans can extend the lifespan of very diverse organisms. Therefore, it should be possible to find others like ibuprofen with even better ability to extend lifespan, with the aim of adding healthy years of life in people."

The goal of taking decades and billions to add just a few years to adult life expectancy doesn't fill me with glee. If that much time and money are to be expended, and I am to become old waiting, I want far better expected outcomes for success: decades of healthy life and rejuvenation, not pills to very slightly slow down the remaining decline. Fund research into repair biotechnologies after the SENS model, not the same old drug development programs that gave us a better knowledge of sirtuins and little else.


View the full article at FightAging
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#2 niner

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Posted 19 December 2014 - 12:52 AM

When are people going to learn that increasing lifespan in yeast, worms, and flies doesn't mean squat?  We need to start driving home the idea that they need to show results in a mammal, or go home.



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#3 rwac

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Posted 20 December 2014 - 12:02 PM

When are people going to learn that increasing lifespan in yeast, worms, and flies doesn't mean squat?  We need to start driving home the idea that they need to show results in a mammal, or go home.

 

You really think you can convince reporters to be realistic, as opposed to reporting on the next big thing?

Worms and flies aren't a bad start.


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#4 corb

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Posted 20 December 2014 - 03:53 PM

Magical pill syndrome.

This is why I steer clear of the supplements forum.


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#5 niner

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Posted 20 December 2014 - 04:04 PM

 

When are people going to learn that increasing lifespan in yeast, worms, and flies doesn't mean squat?  We need to start driving home the idea that they need to show results in a mammal, or go home.

 

You really think you can convince reporters to be realistic, as opposed to reporting on the next big thing?

Worms and flies aren't a bad start.

 

I wasn't thinking about reporters, I was thinking about scientists and journal editors.   Worms and flies aren't horrible, but they aren't a good start.  They are misleading. 



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#6 Avatar of Horus

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Posted 21 December 2014 - 04:27 AM

 

 

When are people going to learn that increasing lifespan in yeast, worms, and flies doesn't mean squat?  We need to start driving home the idea that they need to show results in a mammal, or go home.

 

You really think you can convince reporters to be realistic, as opposed to reporting on the next big thing?

Worms and flies aren't a bad start.

 

I wasn't thinking about reporters, I was thinking about scientists and journal editors.   Worms and flies aren't horrible, but they aren't a good start.  They are misleading. 

 

 

Provided that there isn't a programmed/controlled aspect of the aging process. Data suggest that there is, for example: the GH/insulin/IGF signaling, the so-called dwarf mouse (SENS & Methuselah / Winning the Mprize topic), and also the rapamycin/mTOR. Both are extending the lifespan of worms, flies and mice too.

So in the light of these even if this and similar statements from the #1 post are accepted: "... to mention the fact that slowing down damage accumulation can never be as good as repairing damage in terms of benefits delivered...", IMHO those approaches above and the like still can be valid for life extension research.



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