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Drug abuse and Nootropic Repair

adhd piracetam dopamine drugs alcohol neuroreceptors

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#1 arbettor

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Posted 04 January 2015 - 06:21 PM


Hello,

I’ve been a long time lurker and owe a great many thanks to many of you and the research you have conducted in these forums. I would probably be in a very dark place if I hadn’t come across this website a year ago. What I’m about to write here in this post is going to be a very long read. It is for the most part the most complete account of substances that may or may not have had an impact on my brain. With this account and the help of this forum’s knowledge, I’m attempting to get myself back on track.

I’ll have a Tl;DR at the end of this, but I think there are some interesting pieces of information some members may find useful, or at the very least some thing that confirms their prior hypotheses.

 

Beginning:

In the early part of 2011, I had went to see the counseling center at my university. I was having issues with my at the time girlfriend and it was having an impact on my concentration and school work. After a few tests I was diagnosed with depression and/or ADD of the inattentive kind. I was told it was either an adult onset or something overlooked in my childhood. At the time I didn’t even know what ADD was. My roommates egged me on to accept that diagnosis because I would get “Limitless” pills. The movie had just came out around this time. Then, being the naïve young college kid I was, pressured by my peers I foolishly went ahead and accepted the Doctor’s prescription.

 

It took me many months to realize that the diagnosis was wrong. And many more months later did I learn of the repercussions of that mistake. I was in fact depressed. I didn’t want to admit that truth. I came from a family that believed anything could be overcome. I’ve always wondered why he pushed it on me. I had always had a great memory, I’d be able to commit entire paragraphs to memory reading them once and remember up to 20 scantron answers on tests. I had a high GPA which did take a dip that semester but it wasn’t ADD. I didn’t smoke. I didn’t drink. And I was an incredible athlete with a resting heart rate of 43bpm.

 

I took Adderall 10mg once or twice a day as needed for 3 months. I had a 3 month break. I was working a 9-5 job at this time and struggled to find motivation to do work that was very repetitive and boring to say the least. In October I was back on those little blue pills. Girlfriend dumped me 2 months before. It was the lowest I ever was. Blue for days, my mind actively racing about thoughts of her and the past and what I could have done and nothing but that. I got now work done. Couldn’t even read a book. Back on the pills I was working like a work horse and getting my work done consistently. A problem I was having was waking up each day. I would be forever tired and groggy and unable to get up right away.

 

Fast forward to March of the next year. I stopped getting a script. I was fed up with having to take a pill to get any sort of work done. I assumed if I took a break away from them, my brain would restore homeostasis after a period of time. Didn’t happen. I struggled and borrowed from friends their prescriptions.

 

September of that year (2012) I get a new Doc, same script. Continue to take it. Work is a lot easier. I’m a lot happier as a result of getting my work done. Also begin dating a wonderful girl at the start of the month. Things are great but I also develop a drinking habit because of a knee injury that disallows me from participating in my varsity sport. One blackout incident in October leads to her breaking up with me. Two nights later I see her with another guy and an hour later that night I am introduced to cocaine.

 

Adderall ends by end of October. By this time I’ve given up on it again and try to get back to living without that crutch. My earlier loss also leads me to living a rockstar life of drinking 4 nights a week and continued inhalation of that awful drug. I also adopt cigarettes on those nights. Never buy a pack but there’s always someone with some that’s always willing to give some away. This continues for a year. Alcohol, drugs, and one night stands.

 

Fast forward to Fall 2013. I’m off the white stuff. Even though I haven’t had any of it for 5 months, I deal with dreadful anxiety. I can’t concentrate because my thoughts race about everything else but what I should be focusing on. Counseling center decides I should be on anti-depressants and not stims. I try those for a week. One night smoking weed, for the first time in my life I think about suicide and why people might think it’s a good idea. I flush the anti-depressants and never go back to counseling. Somehow I end up smoking and snorting heroine a few times around this time. A weekend thing. My anxiety bourn from the coke withdrawal evaporates. The feeling is too good and I decide to stop before it gets out of hand. Stopping isn’t an issue. My anxiety is gone and my concentration somewhat better. Insomnia I suffered from before also doesn’t exist.

 

 Fearful of the damage I’d caused myself I search the web. I come across amino acid therapies people are prescribed in rehab. I order a bunch of goodies.

CDP choline

Tyrosine

5-HTP

Fish oil

L-dopamine

l-theanine.

I take one of each of these, the 5htp before bed, and I begin to feel a whole lot better. I also order some piracetam for finals. And oh my God. I was back to square one. I took 1600mg of it twice a day and after 10 days or so, I passed all my finals and focus and motivation was no longer an issue. Throughout the winter break I worked out twice a day getting back into great shape protein shakes, creatine, multiple times a day and I was better than I had been in a long time.

 

I end up back in school and during syllabus week, I have too much fun to say the least. I’m back on the H train on weekends. No issues stopping but I worry that all the work I did over break was lost. I ordered Noopept and Aniracetam. I also have a brief moment with SEMAX which is by far the best Noot, I’ve ever had. Incredible feeling and superhuman mental strength. I’m able to control myself and my recreational use of opiates through these supplements. School is not an issue. The motivation to finish my work is there with my reward before sleep.

Everything is going great. A two week break from the neg substances and following midterms, a weekend to celebrate leaves me almost dead. The second night, I smoke dope, I drink, and then a party I’m at, the drinks are laced with benzos. I end up in the hospital 2 days later. No recollection of the night. In my sleep I vomited and inhaled it. I was about 10mins from dying from asphyxiation.

 

Regarding the asphyxiation incident. One thing I’ve worried about is brain damage. Doctor’s haven’t been particularly helpful in providing insight on the subject. If there is anyone with neurogenesis suggestions that might be beneficial to let me know. I personally don’t feel a substantial difference in my thinking but that’s because if there is I am biased to think its placebo because I think the shortage of oxygen could have killed brain cells. The differences I do perceive are short term memory and focusing on a subject.

 

6 months later. I’m having issues with learning and concentration. I visited a psychiatrist and again end up on stimulants for ADD. Focalin XR now after experimentation with Adderall and Ritalin trials were filled with too many side effects. Taking focalin for a couple weeks now has led me back to where I always end up, which is wanting to quit all these things because I don’t want to be reliant on them for the rest of my life.

 

TL;DR

 

Misdiagnosed with ADD. Prescription meds and life circumstances eventually lead me to abuse a plethora of substances. Used Noots to combat withdrawals. Trying to get life back together but apprehensive about continuing use of ADD meds.

 

My questions:

Could my original misdiagnosis have left me with actual ADHD? Would taking ADHD pills for an extended period of time down regulate the brain to cause one to have the condition? Long periods of time without them have not managed to correct my focus and motivation issues.

 

With regards to the substances I abused, would anyone have any recommendations nootwise- that would help me continue my life as I search for work and partake in job interviews at this time? I am willing to get piracetam and noopept perhaps, SEMAX if it weren’t so expensive, because I’ve had positive reactions to them, but since I have damaged my nueroreceptors and many of them for that matter, is there anything I should be targeting that may help bring about homeostastis.

 

I am also exploring TULIP as a potential addition to my regimen along with binuarual beats. I already exercise 6 times a week. Would Tulip be helpful in bringing back the smart and thoughtful person I was?

 

Does discontinuation of a racetams eliminate the benefits you get while taking them, or do any changes that occur continue on without them?

 

Any recommendations or insights as to what I may have hurt with the substances I abused?

 

 

Feel free to pm me or post to this topic. Many thanks for your input.

 


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#2 Flex

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Posted 04 January 2015 - 11:29 PM

Man, feel sorry for You.

 

Have used cocaine( actually just 3 grams) and a ritalin derivate just out of desperation because I had impairments in social interactions which came with Cannabis abuse during the adolescence.

The Ethylphenidate drove me into a kind of depression who I think is caused by too much Cortisol/Glucocorticoids as a response to dysregulated cellular pathways, but I dont know what exactly.

So it could be because of inflammation/immune response via NF-κB and/or others.

2 years have been past since this and I´m still trying to figure it out on my self, because the Doctors (ca. 6 psychiatrists) where I went were just incompetent and uninterrested.

 

Anyway, I would try to avoid the stims  and the drugs as much as possible. Exept for weed but I would also avoid it, if its not neccessary for Your mood.

Focaline seems to be the lesser evil, but it could be problematic enough, from my Amateurish understanding and knowledge.

 

Try:

- 9-me-ß-cabergoline, Chinese foxglove or its main component Catalpol / Relora. -> the former for Nurr1( which is the upstream target of GDNF), DAT and a few others. The latter for GDNF and few other effects 

- Horny goat weed or its component Icariin -> for increasing TH to get

- Rhizoma Polygonati = Polygonatum sibiricum -> for BDNF & to some extend NGF

- Ginkgo eb761 extract

http://www.sciencedi...306452212008202

 

and/or Zhen-Wu-Tang, which healed damaged dopamine tissue to a extend (I´ve had access to the whole paper):

Protective effect of Zhen-Wu-Tang (ZWT) through keeping DA stable and VMAT 2/DAT mRNA in balance in rats with striatal lesions induced by MPTP

http://www.sciencedi...378874111000547

Check for following integridents before buying, because the study above was made with them:

Radix Paeoniae Alba (30 g), Rhizoma Atractylodis Macrocephalae (10 g),

Rhizoma Typhonii Preparata (10 g), Poria (10 g), Rhizome Zingiberis Recens

 

For job interviews: try rhodiola rosea, but the extract. It inhibits mao-a+b reversible and should help for the lack of dopamine.

 

If it works, You could try Selegiline, but consider(!) its half life of action is 4 weeks and You´ll block all mao-b, so to 100% after 10 days of ~5-10mg in a row.

This could be problematic in regards of the possible side effects like, insomnia, psychosis, anxiety or a desire for drugs. You would then have to hold out for several weeks if Youre taken too much

 

Consider any possible interaction:

thoose could be bloodthinning -> bleedings(!) when mixed e.g. warfarine-like stuff with aspirine-like stuff, metabolic disturbances, insomnia, blood pressure & etc.

So keep the dosage sugesstions and ask a professional for advice

 

I give up nearly every day and pull me up again. I dont know how but I manage it somehow.

We are living in exciting times Stemcells therapies are underway as well as many non-invasive therapies.

Example: Just a few Years ago, the scientist have considered gene therapies for cocaine addiction, which is a kind of resign because the mechanims of cocaine were too compicated and unknown.

Nowadays the mechanisms are clearer and nobody talks about gene therapies anymore. So its seems that this is all more or less a matter of time.

 

Will post tommorow more


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#3 arbettor

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Posted 05 January 2015 - 03:22 PM

Many sincere thanks Flex,

 

i also thought cocaine was helpful in my social interactions but that's because it caused a beguiling haze. I thought it was helpful in my talking to people but the conversations I would have were... well, detrimental to myself to say the least. At one point I was only taking it to prevent memory blackouts. When you're addicted to cocaine, you dont even realize it until you've discontinued use of it for many months. Only then have you regained full control of your own personal analysis. You tell yourself, "I'm not addicted, I can stop any time I want", which it seems like you can because you don't physically crave it on off days, but you can't seem to stop yourself from going out and finding yourself in situations where you'll be offered it multiple times, and of course your twisted brain reminds you you cant say no to free drugs.

 

 

It really had an impact on my life. You say only 3g, but just 3 is really enough to make an impact. What I was taking probably wasn't as high quality as yours which is why after such a long time the effects weren't even worse. There were times where I did have to take a bump before presentations in class because my anxiety would cause me to lose my train of thought and to cause me to stammer and my self-consciousness would cause my anxiety to skyrocket all the more. Klonopin and coke would create killer presentations, but dreadful longer term side effects...

 

 

And yea with cannabis I can also relate to. I've discontinued that as well as unfortunately not only are it's effects not entirely desirable but it tends to cause me anxiety. I love the creativety i get from it but otherwise I either get exceedingly stupid or just full out anxious. Piracetam was something that was able to control the two. Combined with weed it would create a nice euphoric high more body than head that would leave my cognitive abilities in tact and elminate anxiety.

 

 

I have the rosea root extract in an endurance supplement formula I'm using to boost my v02 max. Has ginko cordyceps, co10, and l-arginine among other things. It's incredible how well it works for my sport, but also the calming effects it has. Definetly taking note of that. Why goat weed? and definetly looking into Zhen-Wu-Tang (ZWT.

 

 

The anxiety I still suffer from is no where near as bad as it used to be but it's still there. It's my cognitive speed that I think is effecting it. I'm just not as sharp or my thoughts aren't as quick as I want or need them to be. The focalin is helpful in this sense. Instead of spending 10mins reading a page and getting easily distracted I'm able to continue reading it. My recall is also something I'm having issues with which causes me to panic. I frequently forget words and sometimes my train of thought and argument just seem to disappear from the tip of my tongue. I begin to feel stupid and worry about it and then there's nothing to save me because I spend time worrying about how I'm perceived instead of searching my brain for the answers.

 

 

I've seen Selegine briefly mentioned on the forum in passing before. Never had read too much into it until now. Spent the last two hours reading up about it but there are still many details I need about it. Many people on the forum seem to be against it and advocated the patch verus the oral form of it. Is there a huge difference there? I'm also under 25, and according to some literature it's not recommended until after 30? I would love to take it for a few months to reach homeostatis, but like anything out there besides fish oil, I don't really see myself taking something for years and years just to have those effects.

 

Another thing that worries be about Selegine is the diet limitations. Cheese?! Probably the only food I can't live without! And chocolate, and saurkraut. Some forum members I've noticed didn't mention any side effects from chocolate or alcohol use while on it. Ehhhh would a smaller dose not cause me to be so cautious about what I eat?

 

As for desire for drugs. I have none nor ever will. All i have is memories of those days and absolutely no desire to create new ones. I've caused too much damage to myself already.

 

 

 

To the rest of you just browsing through this and thinking, wow what a junkie. What's he even doing on a forum that is trying to do extend their lives. Well, I had the same opinion about drugs and users a few years ago. Thought it'll never happen to me. I'll never drink smoke or use drugs and live to be a 150. Didn't turn out that way. Thankfully I've got my life back on the right track. I was given a second chance at it and don't intend to lose it. I've got a lot of rights to make up for what I did.

 



#4 Flex

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Posted 06 January 2015 - 08:25 PM

Forget to edit that.

 

Youre welcome :)

 

Horny goat weed because of this:

http://www.longecity...ds/#entry706163

 

But Zhen-Wu-Tang does the same as well as Rehmannia glutinosa, so horny goat is actually not neccessary to try.

http://www.ncbi.nlm....pubmed/20123001

Its just to curb up/repair the dopamine signalling

Try at first Rehmannia and look whether there are any changes.

Even when it dont helps that much in regards of dopamine, its allways good for antioxidant and mood improving properties

 

Sry I dont have much time and I take allways long to respond. Therefore my brief response.

Will post the next days more detailed.


Edited by Flex, 06 January 2015 - 08:27 PM.


#5 Flex

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Posted 12 January 2015 - 05:53 PM

I´ve ordered Zhen wu tang although the preparation hasnt Rhizoma Typhonii Preparata in it but something different.

I will report how it works.

 

 

 



#6 Blackkzeus

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Posted 18 January 2015 - 02:14 AM

Have you received the Zhen Wu Tang? 



#7 Flex

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Posted 18 January 2015 - 04:40 PM

No the shipping is crippling slow.

It should arrive between 20.1.15 and 5th february.

 

I have to add that I couldnt find any preparations with Rhizoma Typhonii Preparata.

(bai) fu zhi could also mean sliced(?) Aconitum carmichaeli, but could also mean 

bai fu zhi = Typhonium giganteum.

It could also be due sloppiness form the Manufacturer or even accidentally by the Scientists.

 

It would be funny when the effects from the study are solely related to Typhonium giganteum :dry:

You can avoid this by looking for a custom composition like:

http://eagleherbs.co...d-herb-formulas


Edited by Flex, 18 January 2015 - 04:46 PM.


#8 arbettor

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Posted 19 January 2015 - 01:36 AM

No the shipping is crippling slow.

It should arrive between 20.1.15 and 5th february.

 

I have to add that I couldnt find any preparations with Rhizoma Typhonii Preparata.

(bai) fu zhi could also mean sliced(?) Aconitum carmichaeli, but could also mean 

bai fu zhi = Typhonium giganteum.

It could also be due sloppiness form the Manufacturer or even accidentally by the Scientists.

 

It would be funny when the effects from the study are solely related to Typhonium giganteum :dry:

You can avoid this by looking for a custom composition like:

http://eagleherbs.co...d-herb-formulas

 

dreadfully slow. Mine is scheduled to come in the week of the 5th.



#9 Flex

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Posted 01 February 2015 - 09:18 PM

Little problem: I´ve ordered 3 boxes and one of them was Zhen-Wu-Tang, but it wasnt in stock.

So I recieved the other two (Angelica sinensis, Kalmegh) and havent been noticed untill the arrivement of the package.

I will post as a proof a screen shot of their response from Amazon in the next days.

 

Seems that I have to look elsewhere for it. Hope this one is it:

Zhen Wu Tang Xin

http://herbprime.com...hen Wu Tang Xin

 

But I dont have a clue what the Xin means.



#10 meth_use_lah

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Posted 02 February 2015 - 03:41 PM

Little problem: I´ve ordered 3 boxes and one of them was Zhen-Wu-Tang, but it wasnt in stock.

So I recieved the other two (Angelica sinensis, Kalmegh) and havent been noticed untill the arrivement of the package.

I will post as a proof a screen shot of their response from Amazon in the next days.

 

Seems that I have to look elsewhere for it. Hope this one is it:

Zhen Wu Tang Xin

http://herbprime.com...hen Wu Tang Xin

 

But I dont have a clue what the Xin means.

 

Pretty sure it's Zhen Wu Tang, I checked Sun Tens webpage and they only have a ZWT product (http://www.suntenglo...w02.php?ID=1444) no ZWTX. I also saw other products that had a Xin ending in online shops, but lacked the Xin ending at Sun Tens webpage.



#11 Flex

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Posted 02 February 2015 - 05:40 PM

Thanks for clarification, had trouble to find it on my own.

Will order it, but this time I´ll order it from somewhere else and it should arrive faster. Arround ~7 Working days.



#12 Flex

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Posted 16 February 2015 - 01:11 AM

Sorry the Shop where I wanted to buy Zhen Wu Tang switched the Name from

http://acugrapheurope.com

to

http://castleblackhealth.com/

recently and dont offer it anymore.

 

But I wont forgett to order it.

I guess somewhere in the next weeks.



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#13 kurdishfella

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Posted 15 February 2022 - 05:33 AM

certain drugs can make your current diseases worse and kick them into gear

Edited by kurdishfella, 15 February 2022 - 05:33 AM.






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