Eon a different imminst longecity person linked to a yahoo article about ibuprofen causing greater longevity at three different species The PLoS journal article is at http://www.ncbi.nlm....les/PMC4270464/ Nifty paper with numerous items new to me readers here might prefer to go directly to the paper.
Notably the most effective drosophila dosage is about .5 mM whereas the c elegans dose is about 200 mM the PLoS paper describes the human similar dosages as
Although ibuprofen had not been tested for its effects on lifespan, other common NSAIDs have been examined. Aspirin slightly extended the lifespan of genetically heterogeneous male mice [54]. In the same study, a nitrosylated flurbiprofen analog had no effect on the lifespan of mice [54]. Even against cyclooxygenases, NSAIDs often display different modes of inhibition and specificity against specific isoforms. For example, flurbiprofen causes irreversible inhibition of cyclooxygenase activity while ibuprofen does not [20]. Another NSAID that has been reported to extend the lifespan of C. elegans is celecoxib [55]. Similar to our results with ibuprofen, celecoxib extended lifespan when added from hatching until death [55]. We also noted that the effective pro-longevity concentrations of ibuprofen were much lower in flies than in worms or yeast (0.5 µM vs. 100–200 µM, respectively; see Fig. 1). The reason for this difference is unclear at present. In healthy humans who took a 600 mg ibuprofen dose up to four times daily, the peak plasma concentration was around 50 µg/ml, corresponding to 240 µM [56]. In another study, a single 400 mg dose of ibuprofen results in a plasma concentration of 8.4 µg/ml, or 40 µM [57]. Therefore, the levels of ibuprofen that extend the lifespan of worms and yeast are in the range of ibuprofen levels reached in people taking the drug at typical doses. Overall, our results add to the growing role of NSAIDs, and ibuprofen in particular. These compounds are relatively safe therapeutics that may combat age-related pathologies and extend the lifespan of divergent organisms, from yeast to invertebrates and possibly mammals.
one of the other nifty things about this PLoS journal article is that they did RNAi genetic engineering on c elegans which caused greater lifespan about similar to the ibuprofen dosing. Also the article notes over a hundred genertic variations on yeast which cause greater longevity
Note perhaps a person here knows which organism has the highest number of orthologous genes to humans. it is actually possible that about 1/400th of a normal human ibuprofen dosage is the longevity optimal dose.
The table from the journal article notes some dose varying responsiveness at drosophila at few hundredths of a human ibuprofen dose
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