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Ibuprofen longevity dosages at PLoS

ibuprofen longevity

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#1 treonsverdery

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Posted 06 January 2015 - 10:07 PM


Eon a different imminst longecity person linked to a yahoo article about ibuprofen causing greater longevity at three different species  The PLoS journal article is at http://www.ncbi.nlm....les/PMC4270464/  Nifty paper with numerous items new to me readers here might prefer to go directly to the paper.

 

Notably the most effective drosophila dosage is about .5 mM whereas the c elegans dose is about 200 mM  the PLoS paper describes the human similar dosages as

 

Ibuprofen: A safe NSAID as a longevity therapeutic?

Although ibuprofen had not been tested for its effects on lifespan, other common NSAIDs have been examined. Aspirin slightly extended the lifespan of genetically heterogeneous male mice [54]. In the same study, a nitrosylated flurbiprofen analog had no effect on the lifespan of mice [54]. Even against cyclooxygenases, NSAIDs often display different modes of inhibition and specificity against specific isoforms. For example, flurbiprofen causes irreversible inhibition of cyclooxygenase activity while ibuprofen does not [20]. Another NSAID that has been reported to extend the lifespan of C. elegans is celecoxib [55]. Similar to our results with ibuprofen, celecoxib extended lifespan when added from hatching until death [55]. We also noted that the effective pro-longevity concentrations of ibuprofen were much lower in flies than in worms or yeast (0.5 µM vs. 100–200 µM, respectively; see Fig. 1). The reason for this difference is unclear at present. In healthy humans who took a 600 mg ibuprofen dose up to four times daily, the peak plasma concentration was around 50 µg/ml, corresponding to 240 µM [56]. In another study, a single 400 mg dose of ibuprofen results in a plasma concentration of 8.4 µg/ml, or 40 µM [57]. Therefore, the levels of ibuprofen that extend the lifespan of worms and yeast are in the range of ibuprofen levels reached in people taking the drug at typical doses. Overall, our results add to the growing role of NSAIDs, and ibuprofen in particular. These compounds are relatively safe therapeutics that may combat age-related pathologies and extend the lifespan of divergent organisms, from yeast to invertebrates and possibly mammals.

 

one of the other nifty things about this PLoS journal article is that they did RNAi genetic engineering on c elegans which caused greater lifespan about similar to the ibuprofen dosing.  Also the article notes over a hundred genertic variations on yeast which cause greater longevity

 

 

 

 

Note perhaps a person here knows which organism has the highest number of orthologous genes to humans.  it is actually possible that about 1/400th of a normal human ibuprofen dosage is the longevity optimal dose.

 

 

The table from the journal article notes some dose varying responsiveness at drosophila at few hundredths of a human ibuprofen dose

 

Attached File  ibuprofen longevity.jpg   106.56KB   4 downloads

 

 

 

 

 


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#2 treonsverdery

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Posted 12 February 2015 - 12:55 AM

Are any people here using longevity ibuprofen? The PDR might have said it has 1.8 hour half-life, suggesting twice per 24 hour dosing

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#3 treonsverdery

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Posted 04 April 2015 - 10:44 PM

With studies on mammals that verify ibuprofen as a longevity drug I think a new pharmaceutical variation PolyIbuprofen could be a lucrative new longevity drug

 

numerous ibuprofens with linker molecules between the active molecules

The linker molecules dissolve with enzymes that are at a variety of tissues

The effect is to have continual gradual ibuprofen longevity effect at tissues a way to get around the 1.8 hour half life

 

one of the ways a researcher could find the active area of the ibuprofen molecule is to make ibuprofen dimers (two identical molecules linked) then note their longevity effects on yeast,  there are numerous ways an ibuprofen molecule is arrangeable, so the version of a dimer that has highest longevity activity suggests the part of the ibuprofen molecule that causes the longevity effect,   so if [  ] is more active than ] [  or [ [   or ] ]    then it is possible to create the polyibuprofen arrangement that causes the greatest longevity

 



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