13 replies to this topic

[chrisp2]

I'm having difficulty finding much information on specific compounds that drive neurogenesis in the nucleus accumbens or hypothalamus.

 

Can anyone point me in the right direction?

[HappyShoe]

Probably the dopaminergic compounds frequently discussed on this site, check those threads. Those substances likely affect the nucleus accumbens since they affect dopamine receptors, something like 9-me-bc, or Dihexa. For the hypothalamus, possibly melatonin or the melatonin based antidepressant drugs like agomelatine(although don't use agomelatine under any circumstances, it causes liver toxicity and was discontinued after its last clinical trial. These are just guesses off the top of my head, but you said you wanted a point in the right direction, so I think it's at least a start. =)

While writing this I googled it. Found a bunch of links.

http://www.sciencema...nt/310/5748/679
Ciliary neurotrophic factor (CNTF) induces weight loss in obese rodents and humans, and for reasons that are not understood, its effects persist after the cessation of treatment. Here we demonstrate that centrally administered CNTF induces cell proliferation in feeding centers of the murine hypothalamus. Many of the newborn cells express neuronal markers and show functional phenotypes relevant for energy-balance control, including a capacity for leptin-induced phosphorylation of signal transducer and activator of transcription 3 (STAT3). Coadministration of the mitotic blocker cytosine-β-d-arabinofuranoside (Ara-C) eliminates the proliferation of neural cells and abrogates the long-term, but not the short-term, effect of CNTF on body weight. These findings link the sustained effect of CNTF on energy balance to hypothalamic neurogenesis and suggest that regulated hypothalamic neurogenesis in adult mice may play a previously unappreciated role in physiology and disease.

http://journal.front....00157/abstract
http://www.neuro.fsu...es Rew 2008.pdf

http://www.ncbi.nlm....pubmed/21143659

For the nucleus accumbens

http://www.jmolecula.../content/1/1/17

http://www.academia....DUCED_ANHEDONIA

Venlafaxine; also known as Efexor
 

[chrisp2]

First..

 

Thank you VERY much for taking the time to reply.  I had done some initial searching online and found some of what you posted.

 

Some thoughts:

 

1) I do use melatonin nightly, sublingual, typically 5mg.

 

2) 9-me-bc at least is available, I need to look into it more.

 

3) Unfortunately just about everything else with the exception of Efexor is not particularly practical.  (E.g, I'm not going to be able to get a DBS implant, CNTF isn't exactly off-the-shelf (and even if it was, the Wikipedia article mentions something about reducing the activity of osteoblasts)

 

4) Efexor I will look into more, would of course need to see a psychiatrist for it, which isn't a huge issue...  Although I'm not sure that would be their first choice to someone who (while being very effective at his job) is very unmotivated otherwise, suffers from anhedonia, and thinks regions of his brain is suffering from grey matter loss...  And it's really the grey matter issue that is driving me to pursue this specific drug (which of course has a number of side effects that aren't particularly pleasant)

 

Here's what I am doing...

 

1)  Exercise daily

2)  Reading daily - at least an hour, probably more.

3)  Current brain stack:

 

Lion's mane, cinnamon, Bacopa, Ashwagandha, Turmeric, Pantethine, Vinpocetine, PS, Alpha GPC AND CDP Choline, Piracetam (branded).  (In addition to EPD/DHA in my normal supplements).

 

I just don't know if ANY of the above three things will have any long term impact on these brain regions.  A google search did not turn up anything on reading or exercise that showed improvement, but I will continue to do them.

 

I saw the NGF spray group buy post, and am intrigued by that.

 

Thank you again for the time you took to share your insight!

 

 

[meth_use_lah]

Captodiamine, a putative antidepressant, enhances hypothalamic BDNF expression in vivo by synergistic 5-HT2c receptor antagonism and sigma-1 receptor agonism.

http://www.ncbi.nlm....pubmed/23863923

 

It's an antihistamine you might be able to get a prescription.. 

 

 

[chrisp2]

Very interesting - thank you...

 

It unfortunately is not approved for use in the United States from what I can tell, making it a bit challenging to get.

[HappyShoe]

I'm pretty sure NSI-189 increases grey matter, but in the hippocampus. Other neurogenics include 7,8 DHF, Royal Jelly(High quality only), Isoxazole 9, and Cerebrolysin. I think NGF promoting substances specifically work on grey matter? So the Lion's Mane you take would be good in that case, as well as Royal Jelly(AMP-N1-Oxide has such effects in the RJ). Check out the threads here on Longecity for these substances respectively.

[chrisp2]

 

Somehow I forgot - I AM taking Royal Jelly - the YS brand.  Maybe I'll double or quadruple the dosage to use it up and buy one of the brands recommended elsewhere on longecity...

 

Cerebrolysin - injecting IM daily with something of (is it pig?) origin?  I think I'll pass. 

 

I have to spend a few hours and do some real research on Isx9, 7,8 DHF, and dihexa. 

 

Cost is not my concern - choosing something safe however is.

 

Thanks again for your help

[Plasticperson]

First..

 

Thank you VERY much for taking the time to reply.  I had done some initial searching online and found some of what you posted.

 

Some thoughts:

 

1) I do use melatonin nightly, sublingual, typically 5mg.

 

2) 9-me-bc at least is available, I need to look into it more.

 

3) Unfortunately just about everything else with the exception of Efexor is not particularly practical.  (E.g, I'm not going to be able to get a DBS implant, CNTF isn't exactly off-the-shelf (and even if it was, the Wikipedia article mentions something about reducing the activity of osteoblasts)

 

4) Efexor I will look into more, would of course need to see a psychiatrist for it, which isn't a huge issue...  Although I'm not sure that would be their first choice to someone who (while being very effective at his job) is very unmotivated otherwise, suffers from anhedonia, and thinks regions of his brain is suffering from grey matter loss...  And it's really the grey matter issue that is driving me to pursue this specific drug (which of course has a number of side effects that aren't particularly pleasant)

 

Here's what I am doing...

 

1)  Exercise daily

2)  Reading daily - at least an hour, probably more.

3)  Current brain stack:

 

Lion's mane, cinnamon, Bacopa, Ashwagandha, Turmeric, Pantethine, Vinpocetine, PS, Alpha GPC AND CDP Choline, Piracetam (branded).  (In addition to EPD/DHA in my normal supplements).

 

I just don't know if ANY of the above three things will have any long term impact on these brain regions.  A google search did not turn up anything on reading or exercise that showed improvement, but I will continue to do them.

 

I saw the NGF spray group buy post, and am intrigued by that.

 

Thank you again for the time you took to share your insight!

 

Hey whats your reasoning behind taking cinnamon?

[chrisp2]

 

Hey whats your reasoning behind taking cinnamon?

 

 

Supposedly good for overall brain health...  Just one article:

 

https://www.psycholo...our-aging-brain

 

(Although now I have to go read up on the "taking with vitamin c" creates a carcinogen; something I was not aware of)

[chrisp2]

I really wish there was a quality (safe, well-accepted) source for NSI-189.

 

Very intrigued by it.

[Flex]

 

 

Hey whats your reasoning behind taking cinnamon?

 

 

Supposedly good for overall brain health...  Just one article:

 

https://www.psycholo...our-aging-brain

 

(Although now I have to go read up on the "taking with vitamin c" creates a carcinogen; something I was not aware of)

 

 

Made a thread about Sodium Benzoate

http://www.longecity...-pfc-activator/

 

It increases Dj-1 (forgot the mechanism) which is good for parkinson.
Cinnamon contains also a CB1 antagonist

Edited by Flex, 21 March 2015 - 02:45 PM.

[normalizing]

happyshoe wtf you talking about? agomelatine is still used and its not discontinued and it seems the liver problems are 0.01% occurrence. i havent even taken it, but its weird you pick on that one specifically spreading false infos. from what i know about it, its just some modified melatonin, which naturally shouldnt be a health problem in any way.

[gamesguru]

Soy phytoestrogens.  Curious that lion's mane is also estrogenic, though it's probably irrelevant, as it raises NGF not BDNF, and not in the frontal lobe.

 

It's rare to find compounds that boost neurotrophic factors in the frontal lobe.

[normalizing]

soy phytoestrogens do not sound like a very good idea to me. you should check some of the compositions of hops. few of the compounds it contains are. sadly extremely estrogenic BUT ALSO, powerful neurotrophic agents. it might party explain why germans are such intelligent hard working assholes!