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Resveratrol prevents age-related memory and mood dysfunction in rats

resveratrol in vivo memory

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#1 malbecman

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Posted 02 February 2015 - 04:40 PM


 Study was done with middle aged rats for 3 months.  Dosing was 40 mg/kg, ip.    Pretty impressive overall, however.

 

http://www.nature.co...75.html#methods

 

 

Sci Rep. 2015 Jan 28;5:8075. doi: 10.1038/srep08075.

Resveratrol prevents age-related memory and mood dysfunction with increased hippocampal neurogenesis and microvasculature, and reduced glial activation.
Abstract

Greatly waned neurogenesis, diminished microvasculature, astrocyte hypertrophy and activated microglia are among the most conspicuous structural changes in the aged hippocampus. Because these alterations can contribute to age-related memory and mood impairments, strategies efficacious for mitigating these changes may preserve cognitive and mood function in old age. Resveratrol, a phytoalexin found in the skin of red grapes having angiogenic and antiinflammatory properties, appears ideal for easing these age-related changes. Hence, we examined the efficacy of resveratrol for counteracting age-related memory and mood impairments and the associated detrimental changes in the hippocampus. Two groups of male F344 rats in late middle-age having similar learning and memory abilities were chosen and treated with resveratrol or vehicle for four weeks. Analyses at ~25 months of age uncovered improved learning, memory and mood function in resveratrol-treated animals but impairments in vehicle-treated animals. Resveratrol-treated animals also displayed increased net neurogenesis and microvasculature, and diminished astrocyte hypertrophy and microglial activation in the hippocampus. These results provide novel evidence that resveratrol treatment in late middle age is efficacious for improving memory and mood function in old age. Modulation of the hippocampus plasticity and suppression of chronic low-level inflammation appear to underlie the functional benefits mediated by resveratrol. 

PMID: 25627672


#2 Mind

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Posted 02 February 2015 - 09:00 PM

Darn...in rats. Can't wait for a human study.



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#3 maxwatt

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Posted 03 February 2015 - 05:06 AM

IF it holds up in humans, resveratrol should prove visible helpful in cases of Parkinson's disease.







Also tagged with one or more of these keywords: resveratrol, in vivo, memory

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