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Curcumin induces senescence independent of DNA damage and ATM.

curcumin senescence

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#1 corb

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Posted 10 February 2015 - 12:23 AM


This paper raises the question of the safety (and efficacy) of curcumin especially when used as an anti aging supplement.

 

 

Curcumin is considered not only as a supplement of the diet but also as a drug in many types of diseases and even as a potential anti-aging compound. It can reduce inflammation that increases with age and accompanies almost all age-related diseases. It has been suggested that curcumin can play a beneficial role in the cardiovascular system. However, there are also data showing that curcumin can induce senescence in cancer cells, which is a beneficial effect in cancer therapy but an undesirable one in the case of normal cells. It is believed that cellular senescence accompanies age-related changes in the cardiovascular system. The aim of this study was to check if curcumin, in a certain range of concentrations, can induce senescence in cells building the vasculature. We have found that human vascular smooth muscle and endothelial cells derived from aorta are very sensitive to curcumin treatment and can senesce upon treatment with cytostatic doses. We observed characteristic senescence markers but the number of DNA damage foci decreased. Surprisingly, in vascular smooth muscle cell (VSMC) activation of DNA damage response pathway downstream of ataxia-telangiectasia mutated (ATM) was observed. ATM silencing and the supplementation of antioxidants, N-acetyl-L-cysteine (NAC) or trolox, did not reduce the number of senescent cells. Thus, we have shown that curcumin can induce senescence of cells building the vasculature, which is DNA damage and ATM independent and is not induced by increased reactive oxygen species (ROS) level. We postulate that an increase in the bioavailability of curcumin should be introduced very carefully considering senescence induction as a side effect.

 

http://www.ncbi.nlm....les/PMC4315775/


  • Ill informed x 1

#2 Kalliste

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Posted 10 February 2015 - 10:34 AM

Paracelsus called it a long time ago as usual. Dose makes poison etc as usually. I only eat roots or powder. This makes me less likely to buy the various pills out there.

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#3 Davin8r

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Posted 10 February 2015 - 06:14 PM

This is worrying, especially for the very latest micellar formulation of curcumin (NovaSol), which can easily raise peak blood levels of curmumin into the 900+ ng/mL range (approximately equivalent to the 2.5 uM concentration in the study posted above).  Fortunately none of the other products on the market come anywhere close to the 900 ng/mL range, so they should all be safe.



#4 Gerrans

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Posted 10 February 2015 - 09:12 PM

I have never wanted to take anything with increased bioavailability. Or things that go through the blood brain barrier more quickly. The body knows how much curcumin, or whatever, it can take, and I do not think we should try to hack round its limits.



#5 Mind

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Posted 10 February 2015 - 09:26 PM

Always remember the dose-response curve. For whatever reason, humans almost always think more is better. This is rarely the case in health or medicine. As mentioned previously "dose makes the poison".

 

That being said, while this study would urge some caution, it is an in vitro study, which are not all that valuable for guidance on human nutrition. Future in vivo studies will tell a truer tale.

 

Otherwise, suppressing cancer (as curcumin is suggested to do) might be a good trade-off for inducing more senescent cells - if you are young-ish (under 40). Research into clearing senescent cells (or nullifying their inflammatory impact) is progressing rapidly. In a decade or two it might be a common-place treatment.

 

I only eat natural curcumin sources, no supps/pills.



#6 mikela

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Posted 07 July 2015 - 04:21 AM

Since we are dealing with potential negatives related to curcumin, any thoughts about this publication .  I am an ex smoker (last smoked about 35 years ago) and take one longvida curcumin pill a day.



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#7 Kalliste

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Posted 07 July 2015 - 05:01 AM

They used transgenic mice for that study which can be bad. And the result seems to go against a lot of other different results. It is worrying though. I have also smoked and I have come to enjoy Turmeric and curry. I tried to email Stephanie Barnes and get a comment but she never replied.



#8 mikela

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Posted 07 July 2015 - 05:10 AM

I did a little more digging and found this longecity thread which appears to cast doubt on the results.  


Edited by mikela, 07 July 2015 - 05:11 AM.


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#9 Jesuisfort

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Posted 23 March 2018 - 12:49 PM

This study is probably an anomaly . For example, i found several study that said vitamin D is bad for health ,   I even found study that said smoking is good for cancer...  Of course,the studies I just mentioned are just anomalies

 

Its statistic, if you study something 100 times , you will find an anomaly

 

 

Just ignore this study

 


Edited by Jesuisfort, 23 March 2018 - 12:50 PM.






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