102 replies to this topic

[GreenmachineX]

This purity thing is a bummer to hear. That aside, has anyone ran this at a very low dose, from 2-5mg? I'm basically looking to elevate IGF-1 levels to normal levels and not much higher and see how it goes.

[Rocket]

This purity thing is a bummer to hear. That aside, has anyone ran this at a very low dose, from 2-5mg? I'm basically looking to elevate IGF-1 levels to normal levels and not much higher and see how it goes.

Is anyone doing blood work? Without it you're really not going to know anything; its all anecdotal and guessing. I also want to see someone post something up so I can see how this compares to cjc1295 that I did pre and post blood work for.

[aconita]

It isn't as much a matter of if it works in rising HGH/IGF1 or not since we have lot of clinical studies with all data one may ask for to confirm its effectiveness (see firsts posts in this tread to find some links and full study).

 

Those clinical studies are by far more significant than any personal blood test report.

 

One thing hasn't been investigated, as far as I am aware of, is the different bioavailability achievable by sublingual administration compared to oral ingestion.

 

It seems there is a quite marked difference, especially so if MK677 is solute in an absorption enhancer as ethanol or DMSO.

 

As I already reported how a dosage of about 8mg/day, which should be tiny according to research, leads to an unexpected magnitude of effects when taken sublingual as a DMSO/ethanol 1:1 solution.

 

This may be worth investigating with blood test for IGF1 since dosage may very likely need to be adjusted in respect to those officially given by available research (typically 25mg/day).

 

From a practical point of view the purity issue (benzyl chloroformate contamination) represents by far the biggest concern, again I invite anybody with proper biochemical knowledge to suggest solutions aimed to remove this nasty impurity.

[ZuoCi]

One thing hasn't been investigated, as far as I am aware of, is the different bioavailability achievable by sublingual administration compared to oral ingestion.

 

It seems there is a quite marked difference, especially so if MK677 is solute in an absorption enhancer as ethanol or DMSO.

 

As I already reported how a dosage of about 8mg/day, which should be tiny according to research, leads to an unexpected magnitude of effects when taken sublingual as a DMSO/ethanol 1:1 solution.

I wouldn't doubt that it would be more effective when taken sublingually. Nothing is less effective that way, and plenty of things are 5x more effective. I have no idea how much stomach acid or the liver breaks down/alters MK-677, but I'd imagine it has at least some impact.

 

I'd love to see studies of course, but from what I recall, sublingual vs oral has an average absorption rate that's over 2x more effective on average(though it ranges from no difference to 100% depending on the substance). Now whether MK is something that's 0% more effective or 800% more effective, I can't say. About the best way to judge would be taking a high oral dose(enough to experience mild sides) and then trying to match it with an equivalent sublingual dose.

 

Your account of 8mg equaling 25mg, closely matches some other experiences I can find.

Edited by ZuoCi, 29 April 2017 - 03:41 PM.

[ZuoCi]

So, I've seen a trend among Australian clinics selling this in injectable form. Apparently according to some rat study from the 90s MK-677 is 50x more potent when dripped in via an IV. But I can't find the study itself.

 

Apparently it's very difficult to keep it suspended though. It crashes in most things, and appears to require Ethyl Oleate to properly suspend. I'm considering testing this at some point(not intravenous, but intramuscular or possibly even subcutaneous).

 

Imagine if it really is 50x more potent when injected... Inject 1/2 mg every other day and a gram lasts for almost a decade.

[John250]

So, I've seen a trend among Australian clinics selling this in injectable form. Apparently according to some rat study from the 90s MK-677 is 50x more potent when dripped in via an IV. But I can't find the study itself.

Apparently it's very difficult to keep it suspended though. It crashes in most things, and appears to require Ethyl Oleate to properly suspend. I'm considering testing this at some point(not intravenous, but intramuscular or possibly even subcutaneous).

Imagine if it really is 50x more potent when injected... Inject 1/2 mg every other day and a gram lasts for almost a decade.

Are you sure you’re not thinking of injectable Ostarine(mk-2866) it’s called s22 forte. My source was interested when he heard about this so he made an injectable form of it and it’s a whole different animal. Dosing is in microdose form compared to oral form and it mainly increases site enhancement. He did the same thing with LGD4033 and results were very similar to Ostarine but a bit stronger. He did the same with GW1516(cardarine) and noticed no difference but his last experiment was with injectable MK-677 and he reported to me it’s by far his favorite. Typically he gets prolactin induced side effects from taking it orally as well as hypoglycemia, bloating and fatigue. Typically he uses a dopamine agonist to counteract the bloating but that is unsafe long-term. In injectable form at only 12.5mg he told me he gets the same benefits of a 25 mg oral dose(strength, pumps, nitrogen retention,etc..) without any increase in prolactin, no hypoglycemia and no bloating and no need for a dopamine agonist. Very interesting what the future development in injectable SARMS could bring. However MK- 677 technically is not a SARM. It’s basically an oral version of Ghrp-6 which is a Growth hormone-releasing peptide.

Edited by John250, 15 February 2019 - 11:41 PM.

[Tamis]

Hi everyone,

 

Being 47 soon I've been looking at MK-677 with interest recently. Are there still no reliable places to buy clean product as I write this ?

 

 

[Shemp999]

Hi everyone,

 

Being 47 soon I've been looking at MK-677 with interest recently. Are there still no reliable places to buy clean product as I write this ?

 

 

https://www.e8compoundherbal.com/

[John250]

Hi everyone,

Being 47 soon I've been looking at MK-677 with interest recently. Are there still no reliable places to buy clean product as I write this ?

https://www.peptidetech.com/buy-mk-677

[maxwatt]

has anyone analyzed the products?

 

https://www.ncbi.nlm...les/PMC5820696/

[John250]

has anyone analyzed the products?

https://www.ncbi.nlm...les/PMC5820696/

Most SARMS come from China and they’re actually expensive if they are real. I think a lot of them are faked with who knows what but MK677 technically is a SARM. It’s a peptide. It’s also around $16/gram if it’s real so when you see the research chems being sold for too cheap that’s a giveaway. Most SARMS could easily be faked with pro or moans or other supplements because the results are not as drastic as MK677. It would be easy to tell if MK 677 was fixed with something else If you’re experienced using it.

Edited by John250, 22 February 2019 - 01:13 AM.

[Tamis]

Hey guys,

 

I started MK-677 3 days ago, I'll keep you updated.

 

Trying to learn more about GH I stumbled on this article, what do you think about it ?

 

https://bjsm.bmj.com.../2/100.full.pdf

Edited by Tamis, 04 March 2019 - 09:21 AM.

[jroseland]

MK-677 seems to be a real-life cheat code for human growth, I would try it in moderation if I could devote serious time weekly to exercise, sleep, and stuffing my face. If I were going to go on a 6-month MK-677 cycle I would get my insulin sensitivity tested every couple of months, the insulin resistance is the one side effect that concerns me...

 

Human growth hormone is a tremendous tool for unlocking greatness in nearly every dimension of human performance, but it comes at a price, between $200 - $1250 monthly. For non-millionaires, MK-677 (Ibutamoren), an oral Ghrelin secretagogue, is the growth hormone alternative, which will give you a lot of bang for your buck, costing $50 - $65 monthly.

Other than the stark economic advantage, what makes MK-677 appealing to me, a guy who normally shies away from “research chemicals” is that it doesn’t replace hormones resulting in your body producing FEWER hormones. It just feeds your pituitary gland the fuel it needs to naturally produce MORE human growth hormone.

 

Listen to podcast: MK-677: The Secret Weapon of Formidable "Lab Rats"