Is there any reason why Genipin would not work in humans if its already been used with no apparent side effects in horses for soft tissue injuries ? ( see here )
It seems it was originally intended and then the Professor involved has a change of heart.
And the following article below ..
Research shows a new treatment modality for tendon injuries could improve healing time in horses and help prevent reinjury. Tom Hedman, PhD, a research associate professor at the University of Kentucky's Center for Biomedical Engineering Coldstream Research Campus' Soft-Tissue Matrix Modification Research Laboratory, introduced to the audience an injectable, nonbiologic treatment approach called NEXT developed to improve the function of mechanically deficient tissues in horses.
During the May 8 Veterinary Science Seminar "ECM2: Introduction to an Injectable Treatment for Mechanically Dysfunctional Tissues with Initial Results from Equine SDFT Testing," Hedman explained that he originally developed the injectable treatment method for use in humans with degenerative disc disease. But upon moving to Lexington, commonly known as "The Horse Capital of the World," Hedman saw potential for the reagent's use in horses.
What Is It?
NEXT (nonsurgical exogenous crosslink therapy, sometimes called ECM2 or exogenous crosslink modification of the extracellular matrix) involves chemical modification--using the plant-derived reagent genipin, which Hedman noted the FDA classifies as nontoxic--of connective tissue to improve mechanical and nutritional properties. Although it sounds complicated, the theory behind NEXT is relatively simple, he said.
Essentially, when tissue is injured (specifically tendons, which are Hedman's current research focus) a veterinarian can hypothetically inject genipin into the lesion. The reagent is designed to provide internal bracing to collagen tissues (the main substance of which tendon is comprised) while increasing nutrient flow into the tissue. Genipin's protein crosslinking activity confers a high tensile strength when injected into collagen.
Hedman relayed that researchers have seen this combination of factors in both healthy and pathologic human and animal tissues help adhere adjacent tissues, increase tear resistance, reduce joint instability, maintain range of motion, and increase tissue durability, among other benefits.
He also noted that NEXT is long-lasting, fast-acting, and low cost compared to other treatment options in human healthcare.
