25 replies to this topic

[timhill88@outlook.com]

Hey guys has anyone noticed their brain smaller pr shrink compared to few years back

[Dorian Grey]

No shrinkage here...  I take my B-Complex!

 

http://www.ncbi.nlm....pubmed/23690582

 

Preventing Alzheimer's disease-related gray matter atrophy by B-vitamin treatment.

Douaud G1, Refsum H, de Jager CA, Jacoby R, Nichols TE, Smith SM, Smith AD.

Author information

 

Abstract

Is it possible to prevent atrophy of key brain regions related to cognitive decline and Alzheimer's disease (AD)? One approach is to modify nongenetic risk factors, for instance by lowering elevated plasma homocysteine using B vitamins. In an initial, randomized controlled study on elderly subjects with increased dementia risk (mild cognitive impairment according to 2004 Petersen criteria), we showed that high-dose B-vitamin treatment (folic acid 0.8 mg, vitamin B6 20 mg, vitamin B12 0.5 mg) slowed shrinkage of the whole brain volume over 2 y. Here, we go further by demonstrating that B-vitamin treatment reduces, by as much as seven fold, the cerebral atrophy in those gray matter (GM) regions specifically vulnerable to the AD process, including the medial temporal lobe. In the placebo group, higher homocysteine levels at baseline are associated with faster GM atrophy, but this deleterious effect is largely prevented by B-vitamin treatment. We additionally show that the beneficial effect of B vitamins is confined to participants with high homocysteine (above the median, 11 µmol/L) and that, in these participants, a causal Bayesian network analysis indicates the following chain of events: B vitamins lower homocysteine, which directly leads to a decrease in GM atrophy, thereby slowing cognitive decline. Our results show that B-vitamin supplementation can slow the atrophy of specific brain regions that are a key component of the AD process and that are associated with cognitive decline. Further B-vitamin supplementation trials focusing on elderly subjets with high homocysteine levels are warranted to see if progression to dementia can be prevented.

 

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Now the only shrinkage I worry about is when I take my wet swim suit off!  

 

Edited by synesthesia, 03 March 2015 - 01:43 AM.

[Galaxyshock]

Antipsychotics cause brain shrinkage

[timhill88@outlook.com]

I have been on anti phychotics and i cant hav a vitamin tablet it sets me off there was a time whrre i took so many differeny supps and nootropics bt has side effects severe headces dizuness im use to it thank you guys

[timhill88@outlook.com]

No one here has anxity to a point they cant have a multivitamjn tablet

[Galaxyshock]

After my abrupt withdrawal from Phenibut few years ago, I had anxiety-restlessness 24/7 for basically several months straight, and even taking B-vitamins would worsen my symptoms. Best help I got from the herb Gotu Kola, it's very gentle yet effective anxiolytic and generally health promoting, maybe give it a try. Gotu Kola also increases neuron growth which could help reverse brain shrinkage / damage from antipsychotics.

 

Hypersensitivity and anxiety like that tend to be dysregulation of histamine and glutamate, and also dynorphins causing the original fear that makes you feel incapacitated.

 

 

[timhill88@outlook.com]

Thanks alot for the reply, yh thats very sad to hear and have you recovered mine happend by tking nootropics vitamins modfinil al at ince throughout day i got side effects like dry mouth dizyness and panic attack and then i stopped al that i stayed with severe anxity and panic attack so nw i go to gym do light runing which helped and now iv sent of hair anaylsis for lab for any metal in body t see if thats the cause after that i wil try that iv had mri ct and eeg scan as well

[timhill88@outlook.com]

I dont wana go back to nootropics and i know i cant abyway i have spent hours n hours looked at all pages on google youtube reviews and know anxity is natural and seen people who had it all of their lives so al i wan is to be normal and to be able to take vitamins and maybe creatine i hve also severe stomach acid and stomach burn the doctor said its linker to anxity and gave me gaviscon which gave me more anxity so im chaning my diet to healthy as much as i cAn although i cant get it perfect bt some balance
Im a bug bealiver in self help self affirmations deep breathing postive thinking i do that
Il keep working at it but i wan t start work as well as its been over a year without a job and have been fired from places due to dizzyness and anxity but people seem to not know and say go to doctor and let me go but doctor sticks to Anti dep or anti phychtoics he dont wanna go anything beyond that or look outside the scale

[Galaxyshock]

I've slowly recovered through long process and with the aid of herbs, exercise, changing my thinking, different remedies and so on. Time and neuroplasticity probably do most of the improvement though. In many ways I've come far. I'm sure things take a turn for the better in your situation too. I don't think anxiety has to be some kind of permanent trait, but getting rid of it does require some dramatic changes and letting go of the old anxiety-built mind - certain die-off may need to happen and conscious decision to surrender. I think you're doing good with the self help remedies, maybe try spending time in nature or taking baths / sauna or swimming. Could be very soothing.

[timhill88@outlook.com]

Ahh yhep i agree so your anxity also started after taking stuff hmm its shame there isnt many studies or warnings

[timhill88@outlook.com]

Would do anything to feel normal again

[timhill88@outlook.com]

What happend when you stopped taking gotu kola did it come back

[Galaxyshock]

I had anxiety before taking Phenibut, one of the reasons why I started using it. I've almost always been more or less anxious individual, tried various things to compensate. Only now I'm starting to feel that I'm getting to the very roots of it and able to permanently overcome the issue.

 

With Gotu Kola the effect is very therapeutic, anxiety did come back but less than it was before taking it and much easier to deal with. Herbs tend to basically always leave you better than where you started, even when you stop taking them. Which is why herbals are always my primary remedy whatever ailment I'm taking them for.

 

I'm sorry I don't have a direct and permanent solution to your problem, it's not that easy. But several things can give you plenty of relief if you're just willing to go with them.

[timhill88@outlook.com]

Yhes sir and thank you soo much for the reply i wil kep u updated have u considered geting metals hair analysis just in case i know u hav t b exosed bt by takin supps we may be n kaybe detoxing liver what do u think
I wasnt anxiouse or had anxity before hand though so wht am i getting this mu h bt only when i take things

[timhill88@outlook.com]

My fam does get depressed and anxity so could b gentics bt dads side is all okay also is there no doctor or hospital best in the world that could reset us the way we wrre

[Galaxyshock]

There's no shortcut, no modern medicine is going to just make it go away - repress it maybe, only to have it come back twice as bad. Ayahuasca or Iboga treatment who knows might purge it all out, then again you might end up traumatized with even more anxious template to work with. I'd rather work the progress smoothly.

 

I haven't gotten hair mineral analysis, I'm not quite sure if those are reliable. Exposure to heavy metals is very possible in modern living though. There's actually some belief that Gotu Kola protects the brain against metals and also detoxifies them, so another plus for the herb.

 

Keeping your liver in good condition is a good idea, anti-psychotics take a toll on that organ too. I've personally had some periods of excess drinking and probably done damage there too. I've used Suma root for liver regeneration.

 

Seriously, give herbs a try, I know you've tried nootropics and supplements, but herbals tend to be a bit different than your random vitamins or chemicals. You can't really go wrong with Gotu Kola, it's very cheap stuff too. Maybe it won't do you much, but I can't really see it hurting either. Well now I'm starting to sound like some kind of snake oil salesman hehe.

[timhill88@outlook.com]

Loll i appricate all ur replies and who knows if it works i wil share if it did and anything additional i believe in honest relations and helping so yh bud and selling u havnt said which one or links so dont worry ur tryin t help n tel me wt worked for u

[timhill88@outlook.com]

Hmm hair analysis wil give me some clue but yh i wil further do reseatch about the herbs and take em i hav t put more work in

[timhill88@outlook.com]

Why do i gey anxity from having a single vitmin tablet

[timhill88@outlook.com]

What is the best method of before trying somthing research, look at side effects, interactions and then try on slow dosage

[Galaxyshock]

What is the best method of before trying somthing research, look at side effects, interactions and then try on slow dosage

 

That's a good way. Once you start learning more you can better know what substances are good for your brain chemistry / situation, and what kind of benefits / sides to expect.

 

 

Why do i gey anxity from having a single vitmin tablet

 

 

I suspect it's excess histamine response that causes that, kinda like allergies. Though sometimes in those supplements the amount of certain vitamins is excessively high. I rather add superfoods to my diet for extra nutrients, never had much of a problem with that compared to synthetic vitamin combos.

[timhill88@outlook.com]

I totally agree my brain is more scared of taking anythung nw bt i do have high histamine i get hayfevers and dust allergies i get hayfever loll even if i open my window in summer so yh bt anti histamines hav showen t b a cause of dementia so i tend to aciod them and they make me diZzy so yh good diet and vitamins abit

[timhill88@outlook.com]

I just looked at synyhinic vitamins compared to natural alot of experts recommend natural than syntic vitamins

[Babychris]

Hello there after some glutaminergic binge (one night I have taken like 20 g of aniracetam...) and modafinil abuse (which was a crazy attitude since I had a SO DRAMATICALLY BAD reaction to it ie anxiety/depression) that leave me with sleep paralysis and some seizure, I have since then a constant head pressure, anxiety. My mind which was very sharp (maybe too much with a overthinking issue) is now blank, I speak much less than before. i'm always tired, my anxiety was warm and active now it's cold and passive, depression etc.

 

My memory is not that much affected.

 

One funny thing is that I can't take any supplement, they all have barely the same action on me... From curcumin to MDMA crazy no ? 

 

I think that is irreversible and I will live all my life with this general heavyness. Too bad

[timhill88@outlook.com]

Thats very sad to hear what made u do that i mean i also abused nootropics and modafinil and ended with anxity to a point cudnt leave house or room for 8 months

[William Sterog]

There's no shortcut, no modern medicine is going to just make it go away - repress it maybe, only to have it come back twice as bad. Ayahuasca or Iboga treatment who knows might purge it all out, then again you might end up traumatized with even more anxious template to work with. I'd rather work the progress smoothly.

 

I haven't gotten hair mineral analysis, I'm not quite sure if those are reliable. Exposure to heavy metals is very possible in modern living though. There's actually some belief that Gotu Kola protects the brain against metals and also detoxifies them, so another plus for the herb.

 

Keeping your liver in good condition is a good idea, anti-psychotics take a toll on that organ too. I've personally had some periods of excess drinking and probably done damage there too. I've used Suma root for liver regeneration.

 

Seriously, give herbs a try, I know you've tried nootropics and supplements, but herbals tend to be a bit different than your random vitamins or chemicals. You can't really go wrong with Gotu Kola, it's very cheap stuff too. Maybe it won't do you much, but I can't really see it hurting either. Well now I'm starting to sound like some kind of snake oil salesman hehe.

 

I used to take Gotu Kola, but it always depress me. Maybe is because of the antiandrogenic activity:

 

 

The inductive effects of Centella asiatica on rat spermatogenic cell apoptosis in vivo.

Heidari M1, Heidari-Vala H, Sadeghi MR, Akhondi MM.

Author information

 

Abstract

Centella asiatica (L.) Urban has been traditionally used for the treatment of various disease and as a food for thousands of years in various parts of the world including eastern Asia, China and India. The goal of this study was to investigate the effects of Centella asiatica aqueous leaf extract on the induction of spermatogenic cell apoptosis in male rats. After lethal dose (LD(50)) assessment of plant extract, rats were divided in five groups. The experimental groups received orally 10, 50, 80 and 100 mg/kg aqueous leaf extract daily for 60 days and the control group received just water. After 60 days, body and testis weight were measured and blood samples were taken from the heart. To evaluate apoptosis and histological changes, tissue samples obtained from rat testes were stained by TUNEL assay and hematoxylin and eosin stain. Results showed that the sperm count, motility, and viability and the number of spermatogenic cells in the seminiferous tubules were significantly decreased compared with the control group. The number of apoptotic germ cells per seminiferous tubule cross-section was significantly increased in the experimental group (18.11 ± 3.5) compared with the control group (8.7 ± 0.81) (P < 0.05). Serum testosterone, follicle-stimulating hormone, and luteinizing hormone levels also showed significant decreases in the experimental groups (P < 0.05). There was also a significant decrease in testis weight in experimental groups compared with the control group (P < 0.05). It is concluded that Centella asiatica has toxicological effects on the reproductive system in male rats and, therefore, it is suggested that leaf extracts of Centella asiatica possess antifertility effects in the male rat.

 

http://www.ncbi.nlm....pubmed/21870191