6 replies to this topic

[bemoored]

Hi all,

 

My sister, age 48, otherwise athletic and in good health, was diagnosed as having an inoperable medulloblastoma (wikipedia.org) in her right cerebellum about 2-1/2 years ago.  There was no evidence of metastases.  She received a pretty standard treatment of targeted radiation and chemotherapy.  Since the end of her treatment about a year ago, no growth has been visible of what remains of the tumor, and her medical team doesn't know whether what remains in the images represents viable malignant cells/tissue.

 

She's doing very well considering, but the treatment has left her somewhat weak and easily fatigued.  I've read the pretty amazing posts and experiences in this C60oo subforum and am considering getting some for her, trying to evaluate the risks and benefits for her as I can (I'm not a scientist or medical practitioner).  As I see it, the potential benefits for her particularly would include

•  
•    relieving some of her weakness and fatigue, if the fatigue has some damaged-mitochondrial component
•  
•    inhibiting any future metastasis if there are still viable malignant cells
•  
•    'switching on' the mitochondria of any remaining malignant cells
•  

I don't know enough to identify the risks in her particular situation, let alone evaluate them - the additional risks, that is, given the medulloblastoma.  From wikipedia I gather the pathogenesis of medulloblastomal cells isn't well understood, but is suspected to be associated with faulty differentation of cerebellar stem cells.  Of course, the last thing I would want to do is give my sister something that would encourage the proliferation of new medulloblastomal cells.

 

So, I've been turning this over in my mind without resolution yet.  Most prudent would be to not give her c60oo and only consider it again if there is evidence of new tumor growth.  But the potential benefits of giving it to her now are striking, both in reducing her fatigue and potentially preventing a recurrence or metastasis of the medulloblastoma.  I'd welcome and appreciate any thoughts any of you may have.

 

Just to say, I've been taking C60oo myself for about a month now (purchased from carbon60), having taken a total of about 25mg in a fairly ad hoc fashion - first daily, now every three or four days.  I'm male, 59, 5'9", 175 lbs, in pretty good health.  I've experienced some of the milder typical effects reported here:  increased endurance during exercise, some increased tolerance for alcohol; maybe some new hair growth starting; and a small, suspicious-looking flaking mole on my forearm that I've had about five years seems to be fading (I've applied C60oo to it topically a few times).

 

Thanks much...

 

[Razor444]

'Cancer & C60-Olive Oil in a Mouse Model'.

 

The above study results will be available in around one year's time, I believe.

[resveratrol_guy]

While I'm no expert on medulloblastoma, if it were me, I'd be doing everything possible to prevent metastasis, which for the most part means protecting oxidative phosphorylation at the expense of glycolysis. c60oo, Longvida, and maybe pterostilbene would be high on the list. But so too would coconut MCT oil and a ketogenic diet in general. If it all failed, I would be looking to 3-bromopyruvate (maybe even lumbar injected). There is a treasure chest of anticancer information here on Longecity, which are well worth the hours of reading, but these are some big hammers that come to mind.

 

Edited by resveratrol_guy, 06 March 2015 - 04:39 AM.

[Kalliste]

MitoQ might be a safer option as it is somewhat OK for human use and has a good anti cancer profile. C60 might be a sweet deal, but if she is not in mortal danger and doing OK I think your suspicion is semi valid. Maybe it could restart cancer though I doubt it.

Or else go the traditional route:
1. Calorie restriction orPF if she can manage.
2. Exercise and meditation.
3. Curcumin, berries, green tea, nuts, probiotics.
4. Hot and cold showers

[Logic]

Reversing Mitochondrial Aging with NAD precursors

"...deficiency of NAD+ in the nucleus of muscle cells produces a state of “pseudohypoxia”, where there is adequate oxygen but high levels of HIF-1α. This results in the inhibition of the mitochondrial transcription factor, TFAM, which inhibits the expression of mtDNA. As a result, mitochondria do not produce the proteins encoded in mitochondrial DNA that are required for “forward electron transport” and ATP production. “Reverse electron transport” occurs and high levels of free radicals are produced, giving the exact picture of aging. In this picture cells are dependent on aerobic glycolysis in the cytoplasm and cannot burn fat. They develop the exact metabolic picture of cancer, called the Warburg effect. The mitochondrial dysfunction and this Warburg-type metabolism are fully reversible with the supplementation of NAD+ precursors. This is the #1 story for 2013..."
http://www.anti-agin...-aging-in-2013/

How to Prevent Cancer and Aging with the Same Strategy
http://www.anti-agin...-same-strategy/
 
Scroll down to:
Glucosamine supplementation and other research approaches to mitochondrial health
http://www.anti-agin...-for-longevity/
http://www.anti-agin...-for-longevity/
 
Mebendazole:
http://www.longecity...ndpost&p=513628

CD47:
http://www.longecity...therapy-target/

The huge 'Cancer Knowledge' thread:
http://www.longecity...nowledge/page-1

Google site search:
http://www.google.co...=0&gsc.q=cancer

 

Now you sorry you asked as you don't have 3 months free to read all this. 

[niner]

bemoored, if I were your sister, I would take c60oo.  Switching off the metastatic phenotype appears to be a class effect of mitochondrial antioxidants, and I think that c60oo is the best of those.  While there have been more publications on MitoQ, c60oo has been in more people, albeit not in a formal medical setting.  There are far more reports of improved endurance and energy with c60oo than with MitoQ as far as I'm aware.

[Razor444]

bemoored, if I were your sister, I would take c60oo.  Switching off the metastatic phenotype appears to be a class effect of mitochondrial antioxidants, and I think that c60oo is the best of those.  While there have been more publications on MitoQ, c60oo has been in more people, albeit not in a formal medical setting.  There are far more reports of improved endurance and energy with c60oo than with MitoQ as far as I'm aware.

 

I've used MitoQ and c60oo together—and I think they're complementary! I've always taken c60oo with MitoQ, so I can't comment for sure on their synergy.

 

But I have positive effects with MitoQ, and then additional positive effects when c60oo is added.