I was interested in Reactive Oxygen Species and gray hair, as I have seen reversal of gray hair from my consumption of C60.
Apparently graying is caused by H2O2 in the follicles, in turn caused by decreased catalase and methionine sulfoxide reductase A and B protein expression
http://www.ncbi.nlm....pubmed/19237503
So we have decreased catalase and decreased metalloprotein reductase (Meth-Sulf=O) leading to higher levels of ROS, at least in the hair follicle.
Then I did a search for increased catalase, which led me here:
Effect of the Lycium barbarum polysaccharides on age-related oxidative stress in aged mice.
"Result showed that increased endogenous lipid peroxidation, and decreased antioxidant activities, as assessed by superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GSH-Px) and total antioxidant capacity (TAOC), and immune function were observed in aged mice and restored to normal levels in the polysaccharides-treated groups."
http://www.ncbi.nlm....pubmed/17224253
So -- Goji - in vivo in geriatric mice raises many endogenous antioxidants including catalase, SOD, and GSH-Px -- so far so good , what about in humans??
Lycium barbarum (goji) juice improves in vivo antioxidant biomarkers in serum of healthy adults.
"The study population included 50 Chinese healthy adults aged 55 to 72 years. In vivo antioxidant markers, consisting of serum levels of superoxide dismutase (SOD), glutathione peroxidase (GSH-Px), and lipid peroxidation (indicated by decreased levels of malondialdehyde, MDA) were examined preintervention and postintervention with GoChi or placebo (120 mL/d). In the GoChi group, antioxidant markers significantly increased by 8.4% for SOD and 9.9% for GSH-Px between the preintervention and postintervention measurements, whereas MDA were significantly decreased by 8.7%. In addition, the SOD, GSH-Px, and MDA levels in the GoChi group were significantly different from those in the placebo group at the postintervention time point, with increases of 8.1% and 9.0% and a decrease of 6.0%, respectively."
- apparently LBPs from Goji cause in vivo increases of SOD, and GSH-Px in healthy human adults, and a decrease in MDA (maybe it increases catalase as well?)
I plan to definitely add Goji supplementation in the form of powdered (by me) organic dried goji fruit to my use of C60OO.
Thoughts?