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Any prebiotics/probiotics backed by clinical studies out there?

probiotics prebiotics

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#1 nickthird

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Posted 19 March 2015 - 10:31 PM


The big problem with the pr*biotic market is the huge hype and overwhelmingly high amount of non standard Amazon reviews of products (not verified purchases, 5/5 ratings, people posting a first review or just nonsense). Not to mention the false advertising. Basically its gotten to the state of the diet pills.

 

I have seen some products that are backed by studies, but after closer inspection those studies tend to be of very low quality and heavily funded by the companies (in one study they actually wrote that at the time the scientists were not working for the company, but now they are... however there are no conflicts of interest to report...).



#2 Dorian Grey

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Posted 20 March 2015 - 12:07 AM

For what it's worth (Wikipedia): http://en.wikipedia....illus_rhamnosus

 

Lactobacillus rhamnosus GG (ATCC 53103) is a strain of L. rhamnosus that was isolated in 1983 from the intestinal tract of a healthy human being; filed for patent on 17 April 1985, by Sherwood Gorbach and Barry Goldin,[2] and the 'GG' derives from the first letters of their surnames.[3] The patent refers to a strain of "L. acidophilus GG" withAmerican Type Culture Collection (ATCC) Accession No. 53103; later reclassified as a strain of L. rhamnosus. The patent claims the L. rhamnosus GG (ATCC 53103) strain is acid- and bile-stable, has a great avidity for human intestinal mucosal cells, and produces lactic acid. Since the discovery of the L. rhamnosus GG (ATCC 53103) strain, it has been studied extensively on its various health benefits and currently L. rhamnosus GG (ATCC 53103) strain is the world's most studied probiotic bacterium with more than 800 scientific studies.

The genome sequence of Lactobacillus rhamnosus GG (ATCC 53103) has been decoded

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I've taken this (brand name Culturelle) for several years and had impressive results.  


Edited by synesthesia, 20 March 2015 - 12:08 AM.

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#3 Gerrans

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Posted 20 March 2015 - 12:15 PM

I have read nothing that has convinced me to take probiotics, as such. But I do think about prebiotic processes, and so I eat cooled potatoes for resistant starch, and I mix onion powder, which contains FOS, into my sauces. Plus I eat a mix of fibre-containing foods. My belief is that for most people a good diet will look after the gut, though I appreciate that people with certain health issues will want to try everything they can to improve their health via digestive supplements, etc.


Edited by Gerrans, 20 March 2015 - 12:17 PM.

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#4 timar

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Posted 21 March 2015 - 09:20 AM

The dairy and biotech companies holding patents for probiotics (mostly dairy-related) have done a lot of research on their respective strains, much of it published. Recently there has been an exhaustive review on Chr. Hansen's bifidobacterium animalis subsp. lactis BB-12. Hansen ist much more transparent about their research than Danone or Nestlé, as they license their strains instead of directly selling products to the consumer. On their website, they provide a research summary with complete sources for each strain they license, including of course all clinical trials.

 

In Germany, you can get a freeze-died yogurt starter with BB-12 and LA-5 at eBay or some health food stores for ~2€/g. In my experience, 1 g is sufficient for incubating approximately 100 l of yogurt, so you pay about 2 cent per liter of fermented yogurt - the cheapest way you will ever get your probiotics (because you only pay for 1% of the bacteria and breed 99% yourself)! The best thing is that you can add prebiotics before fermentation and thus further increase the CFU of the probiotic strains and their viability after ingestion. Based on a literature review, I have choosen inulin and lactulose (20 g/l, resp.) as the optimum substrates for LA-5 and BB-12, respectively. Using organic, pastured milk, a liter of my synbiotic yogurt costs me about 1.50€ - just as much as a liter of ordinary, non-organic non-pre/probiotic yogurt from the store.


Edited by timar, 21 March 2015 - 09:29 AM.

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#5 Chris_T_Malta

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Posted 27 April 2015 - 03:54 AM

A naturopath has diagnoized my gf with Candida Albicans overgrowth (something I potentially have too) and I have spent a couple of hours watching videos about this. I am not sure on how scientific the whole thing is although the fungi/yeast creature surely exist in each and every human gut. 

 

All stuff I watched stated that in order to counter-balance this overgrowth, the gut must be flooded with pro-biotics and the environment must be more acidic than alkaline (since the Candida grows faster in alkaline states). Seems it feeds best on sugars and so my gf was told to avoid sugars and any product containing yeast.

 

Anyone has read any reputable scientific source about this? I have this impression that there is a lot of snakeoil business going around this particular health problem. In one video I found on youtube, it basically linked the "conglomerates" with the growth of this disease due to their preference for artificial sweeters in foodetc. Another video linked candida with cancer because all tumours are white.. (?!). Anyway I am sceptical by nature.

 

I posted this here because I think that if we're going to discuss pro/pre-biotics from a scientific pov, we're going to discuss the micro-biome business as a whole.

 

 

 

 



#6 Chris_T_Malta

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Posted 27 April 2015 - 03:58 AM

Ps. This weekend I started using this product to boost my pro-biotics: http://www.actimel.c...your-questions/

 

Will have it first thing in the morning when my stomach acid should be the least harsh possible.

 

Before this, I used to take Multibionta Pills: http://www.seven-seas.com/multibionta- No longer convinced this is the best way to get pro-biotics.

 

 

 



#7 OneScrewLoose

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Posted 27 April 2015 - 05:07 AM

Candida overgrowth in healthy people is pure BS. What symptoms is she having?

There isn't much good research on probiotics. Here's some studies I found for "Align":

http://www.ncbi.nlm.... infantis 35624

 

But if you're gonna use those, check the impact factor of the journals publishing those studies.


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#8 Chris_T_Malta

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Posted 27 April 2015 - 06:20 AM

Candida overgrowth in healthy people is pure BS. What symptoms is she having?

There isn't much good research on probiotics. Here's some studies I found for "Align":

http://www.ncbi.nlm.... infantis 35624

 

But if you're gonna use those, check the impact factor of the journals publishing those studies.

 

Her symptoms are the classic cluster of stuff that is hard to pinpoint to a particular cause (for example: general fatigue, tense/anxious) and that's why I was sceptical and trying to do my own research.

 

There could be a way to verify this in a scientific way: stool analysis. From what I read, candida must not exceed the 20% of the microbiome.

 

This candida overgrwoth idea seems to be linked to that group of ideas which are hostile to yeast, sugar and grains in general, including people like Dr. Perlmutter (author of Brain Grain).

 


Edited by Chris Tanti, 27 April 2015 - 06:46 AM.


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#9 OneScrewLoose

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Posted 27 April 2015 - 08:25 PM

I would treat it as general anxiety. Anxiety can cause bowel symptoms as increased activity in the sympathetic (fight or flight) system can cause reduced efficacy in digestion. Start with some over the counter Ashwagandha and see if that helps her calm down at all.







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