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How does olive oil make C60 nontoxic?

c60 olive oil toxicity

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#1 NilsOlav

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Posted 09 April 2015 - 04:32 PM


Can someone explain to me exactly what it is about olive oil that makes C60 nontoxic? Can you give another example of a chemical/ingredient that is toxic alone, but when administered in olive oil, it becomes safe? I found this quote on the C60 antiaging site:

 

"Fullerene toxicity exist, but only occurs when fullerenes lump into nanoparticles or crystallize into larger structures. This happens in watery solutions of fullerenes but has been proven to be impossible with lipofullerenes (C60 in oil). The lipid chains attached to the C60 molecule prevent clumping or crystallization"

(http://c60antiaging....fects-toxicity/)

 

Okay, so...that settles it? Olive oil makes it completely safe? I am not familiar with this ability of olive oil to make something that may be toxic nontoxic...can someone please show me some examples of olive oil making something else nontoxic? Is mercury in olive oil nontoxic? How about cadmium? Arsenic in olive oil?


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#2 Kalliste

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Posted 09 April 2015 - 05:12 PM

Nobody knows for sure. Some studies indicate it can be a good substance under some conditions and bad in other ways. There is a lot of scientific confusion with regards to C60-OO. It will be many years before we know what it does to humans at what dosages.



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#3 Nuke

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Posted 09 April 2015 - 06:26 PM

You see the olive oil as some poison antidote, that it is not.

 

2 random thoughts.

 

1. C60 seems to bond with the triglycerides. Its not a solution, but a new compound. A lot of the time the precursors for a pharmaceutical substance is toxic. 

2. The damage the n60 do may be akin to something like asbestos. Not really toxic, the damage it do is physical, not chemical. It may cause inflammation and ROS by being there physically.


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#4 renfr

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Posted 11 April 2015 - 09:19 PM

If you're scared of possible nC60 contamination or toxicity, just take some vitamin C with it : http://bit.ly/1ygAbjB

 

"The damage of cell membrane was induced by reactive oxygen radicals produced by nC60 in water, and it was completely prevented by addition of the antioxidant ascorbic acid."

 

I'm doing that because Vaughter's C60 is highly concentrated (0.9mg/mL), better safe than sorry.


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#5 niner

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Posted 11 April 2015 - 09:39 PM

I agree with Nuke.  When C60 is in the form of large aggregates ("nano-c60" -- nano sounds small, but these are large compared to single molecules), it can engage in chemistry and photochemistry that it just doesn't do when in the form of a single molecule.  This is true of a number of substances, where their properties are very different in the submicron domain, compared to either the bulk or molecular state.   C60 reacts with olive oil to produce a new compound, as Nuke pointed out, and this compound is soluble in olive oil in a molecular state.  Detoxification by olive oil is not a universal property.


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#6 Kalliste

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Posted 12 April 2015 - 05:53 AM

If you have access to research papers NilsOlav, you should read this one as a general primer on nano-antioxidants.

Gruber J, et al, Mitochondria-targeted antioxidants and metabolic modulators as pharmacological interventions to
slow ageing, Biotechnol Adv (2012), http://dx.doi.org/10...adv.2012.09.005


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#7 Turnbuckle

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Posted 12 April 2015 - 11:09 AM

"Fullerene toxicity exist, but only occurs when fullerenes lump into nanoparticles or crystallize into larger structures. This happens in watery solutions of fullerenes but has been proven to be impossible with lipofullerenes (C60 in oil). The lipid chains attached to the C60 molecule prevent clumping or crystallization"

 

 

This is just marketing BS. No one has proven anything of the sort. In fact, crystals of C60 have been imaged in test animals fed C60 in EVOO, so that part is certainly false. And further, C60 in EVOO is a witch's brew of adduct chemistry. No one can say that everything in it is nontoxic.


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#8 APBT

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Posted 12 April 2015 - 05:59 PM

Attached File  Mitochondria-targeted antioxidants and metabolic modulators as pharmacological.pdf   1.58MB   26 downloads


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