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Curcumin interaction with prescription drugs?

curcumin prescription drugs theracurmin

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#1 j87

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Posted 22 April 2015 - 04:44 AM


I've read that curcumin may interact with prescriptions drugs the same way grapefruit does, Theracurmin has a half life of 13 hours. Would it be safe to consume theracurmin 12 hours away from prescription drugs? I'm wondering if the liver enzyme inhibition is still going on after several hours.


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#2 j87

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Posted 23 April 2015 - 08:45 PM

Curcumin inhibits p450 CYP3A4

 
The effects of grapefruit juice on the enzyme last up to 3 days. Assuming curcumin works similarly, I can not simply take it 12 hours away from prescription drugs.
 
 
Unfortunately, I have found that many other supplements do the same thing. This is very disheartening as I will have to discontinue giving my dad most of the supplements I ordered him. 
 
DIM (enhances the liver enzyme) 
 
 
apigenin
Lineweaver-Burk plot analysis indicated that apigenin and its dimer amentoflavone and imperatorin displayed a mixed type of inhibition on CYP3A4 or CYP2C9.
 In addition, apigenin, to some extent, is a potent inhibitor of the cytochrome P450 (CYP) enzyme 
 
ginger (conflicting)
 
quercetin
 
reishi
 
boswelia (I read that it ihibits cy3a on some site, now I can't find it)
 
pomegranate
 
licorice
 
rosemary
 
sulphoraphane

 

 

I feel like this info should be more available, maybe a list of supps that interact with prescription drugs should be compiled stickied somewhere. 



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#3 j87

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Posted 24 April 2015 - 07:05 PM

"All of those are in vitro studies in test tubes. There are no reports of drug interactions in the clinic. Often test tube studies are not confirmed in human studies because of the complexities of the human body. The test tube studies isolate specific proteins (enzymes) and then evaluate interactions. In human studies, circumin may never reach those enzymes, thus it may not cause any clinically meaningful interaction.
 
Negative research is rarely published ... but here is a clinical study with tumeric and 3 different drugs: http://www.ncbi.nlm....pubmed/22725836
Results -- No significant interaction."


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#4 OneScrewLoose

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Posted 28 April 2015 - 01:45 AM

It looks like, overall, Curcumin seems to act as a CYP34A Inducer:

 

http://www.nature.co.../srep06587.html

 

Possivle CYP2C9 Inhibitor as well:

http://www.ncbi.nlm....pubmed/24517573

 

Be careful if you are taking things that are metabolized by these enzymes. It seems the exact effects are not 100% clear.







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